> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/zavegepant-hydrochloride-d2e0be92-6d36-4681-8b60-b6cf5492ea41 > Record changed: 2026-10-13 # Zavegepant hydrochloride Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) First approval year 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) ## Development status **First approval year** 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) **Drug name** Zavegepant hydrochloride Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) **Molecular weight** 675.28 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) **Structure (SMILES)** Cc1cc(C\[C@@H\](NC(=O)N2CCC(c3cc4ccccc4\[nH\]c3=O)CC2)C(=O)N2CCN(C3CCN(C)CC3)CC2)cc2cn\[nH\]c12.Cl Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) ### Brand names (2) - zavzpret - Zavzpret ### Other names (14) - bhv 3500 hydrochloride - BHV-3500 hydrochloride - bms 742413 03 - bms 742413 hydrochloride - BMS-742413 hydrochloride - BMS-742413-03 - zavegepant hydrochloride - Zavegepant hydrochloride - Zavegepant hydrochloride \[USAN\] - Zavegepant hydrochloride \[WHO-DD\] - zavegepant hydrochloride usan - zavegepant hydrochloride who dd - zavzpret - Zavzpret ## Identifiers **ATC classification codes** - N02CD08 Sources for recorded values Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2637955) **CAS registry numbers** - 1414976-20-7 **ChEMBL ID** CHEMBL4650220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) **InChIKey** VQDUWCSSPSOSNA-RYWNGCACSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650220) **PubChem compound IDs** - 134819878 **FDA ingredient codes (UNII)** - 000QCM6HAL ### RxNorm IDs (RxCUI) (2) - 2637955 - 2637956 ## Regulatory information ### United States **Applicant** PFIZER **Approval date** 9 Mar 2023 **Application number** NDA216386 ### Other regulatory facts **Patents** 1 **Designations** 0 **Earliest recorded loss of exclusivity** 26 Jun 2034 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** \-gepant #### Administration routes - topical ### Mechanisms of action - **Mechanism** Calcitonin gene-related peptide type 1 receptor antagonist **Action type** Antagonist **Target** Calcitonin gene-related peptide type 1 receptor **Protein identifier** Q16602 ### Open Targets mechanisms - **Mechanism** Calcitonin gene-related peptide type 1 receptor antagonist **Action type** Antagonist **Target** Calcitonin gene-related peptide type 1 receptor ### Investigated indications - **Condition** Migraine Disorders **Highest recorded phase** 4 **Condition identifier** MONDO:0005277 **Subject identifier** D008881 ### Open Targets indications (2) - **Condition identifier** MONDO\_0005277 - **Condition identifier** MONDO\_0005277 **Highest recorded phase** 4 ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 3 **Polar surface area** 120.67 **Calculated partition coefficient (ALogP)** 3.45 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 6 **Heavy atoms** 48 **Molecular formula** C36H47ClN8O3 **Monoisotopic mass** 674.3459651 **Natural product** No ## National Drug Codes - 0069-3500 - 63539-135 ## Related records ### Trials (17) - A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department - A Study to Compare Zavegepant Concentration Using Samples Collected From the Vein Versus Patient-Centric Microsampling - A Study to Evaluate the Efficacy and Safety of Oral Zavegepant in Migraine Prevention - A Study to Learn About the Study Medication, Zavegepant, in Healthy Volunteers - A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine - A Study to Learn About the Study Medicine Called Zavegepant in Healthy Chinese Adult Participants - A Study to Learn About Zavegepant as a Treatment for Multiple Migraine Attacks in Adult Participants - [A Study to Learn About Zavegepant as the Acute Treatment of Migraine in Asian Adults](https://trialight.com/data/trial/a-study-to-learn-about-zavegepant-as-the-acute-treatment-of-35d29eb4-e01d-4d68-b1b0-97185b6e862d.md) - A Study to Learn How the Study Medicine Called Zavegepant is Taken Up Into Blood and Breast Milk of Healthy Breast-Feeding Women - Acute Migraine Treatment in the ED With Gepants - Acute Treatment Trial in Adult Subjects With Migraines - Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications - Long-term Safety Study of BHV-3500 (Zavegepant\*) for the Acute Treatment of Migraine - Randomized Trial in Adult Participants With Acute Migraines - Safety and Efficacy Active Drug vs. Placebo in Subjects With Asthma - Safety and Efficacy Trial of Zavegepant\* Intranasal for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen - Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster Headache ### Approved for (1) - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) ### Targets (1) - [CALCRL](https://trialight.com/data/target/calcrl-ab682234-2bfa-51bd-a9eb-e0d3e9a4ee16.md) Calcitonin gene-related peptide type 1 receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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