> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/zavegepant-f0d53974-a354-467a-a023-a528b34d96e9 > Record changed: 2026-11-04 # Zavegepant Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) First approval year 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) ## Development status **First approval year** 2023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) **Drug name** Zavegepant Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) **Molecular weight** 638.82 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) **Structure (SMILES)** Cc1cc(C\[C@@H\](NC(=O)N2CCC(c3cc4ccccc4\[nH\]c3=O)CC2)C(=O)N2CCN(C3CCN(C)CC3)CC2)cc2cn\[nH\]c12 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) ### Other names (16) - bhv 3500 - BHV-3500 - bms 742413 - bms 742413 01 - BMS-742413 - BMS-742413-01 - vazegepant - Vazegepant - zavegepant - Zavegepant - zavegepant \[INN\] - ZAVEGEPANT \[USAN\] - Zavegepant \[WHO-DD\] - zavegepant inn - zavegepant usan - zavegepant who dd ## Identifiers **ATC classification codes** - N02CD08 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) **CAS registry numbers** - 1337918-83-8 **ChEMBL ID** CHEMBL2397415 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) **InChIKey** JJVAPHYEOZSKJZ-JGCGQSQUSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2397415) **PubChem compound IDs** - 53472683 **RxNorm IDs (RxCUI)** - 2637955 **FDA ingredient codes (UNII)** - ODU3ZAZ94J ## Regulatory information ### United States **Applicant** PFIZER **Approval date** 9 Mar 2023 **Application number** NDA216386 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Pharmacology name** zavegepant **Type** Synthetic organic **Drug name stem** \-gepant **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - topical ### Mechanisms of action (6) - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** RAMP1 **Protein identifier** O60894 **Median affinity** 10.66 **Affinity units** pKB - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** RAMP1 **Protein identifier** O60894 **Median affinity** 10.64 **Affinity units** pKi - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** CALCRL **Protein identifier** Q16602 **Median affinity** 10.66 **Affinity units** pKB - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** CALCRL **Protein identifier** Q16602 **Median affinity** 10.64 **Affinity units** pKi - **Mechanism** Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist **Action type** Antagonist **Target** Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 **Protein identifier** O60894 - **Mechanism** Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist **Action type** Antagonist **Target** Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 **Protein identifier** Q16602 ### Open Targets mechanisms (2) - **Mechanism** Calcitonin gene-related peptide type 1 receptor antagonist **Action type** Antagonist **Target** Calcitonin gene-related peptide type 1 receptor - **Mechanism** Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist **Action type** Antagonist **Target** Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 ### Investigated indications (3) - **Condition** Asthma **Highest recorded phase** 1 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 - **Condition** Migraine Disorders **Highest recorded phase** 3 **Condition identifier** MONDO:0005277 **Subject identifier** D008881 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 2 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (5) - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005277 - **Condition identifier** MONDO\_0005277 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0100096 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 2 ### Trial references (7) - NCT03872453 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03872453) - NCT04408794 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04408794) - NCT04571060 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04571060) - NCT04804033 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04804033) - NCT05989048 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05989048) - NCT04346615 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04346615) - NCT04987944 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04987944) ## Dosing **Dose** 10mg **Route** Intranasal **How often** As needed ### Conditions of use - Maximum 10mg per 24 hours ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 3 **Polar surface area** 120.67 **Calculated partition coefficient (ALogP)** 3.45 **Calculated partition coefficient (XLogP)** 3.1 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 6 **Heavy atoms** 47 **Molecular formula** C36H46N8O3 **Monoisotopic mass** 638.36928736 **Natural product** No ## Evidence counts **Recorded assays** 50 **Active assays** 6 ### Active assay types - Confirmatory ## Pharmacologic actions - Calcitonin Gene-Related Peptide Receptor Antagonists Pharmacologic agents that block NOCICEPTIVE PAIN signaling from CALCITONIN GENE-RELATED PEPTIDE RECEPTORS. They may be useful for the treatment of pain associated with MIGRAINE DISORDERS and OSTEOARTHRITIS. ## Biological measurements These details could not be displayed. ## Related records ### Trials (17) - A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department - A Study to Compare Zavegepant Concentration Using Samples Collected From the Vein Versus Patient-Centric Microsampling - A Study to Evaluate the Efficacy and Safety of Oral Zavegepant in Migraine Prevention - A Study to Learn About the Study Medication, Zavegepant, in Healthy Volunteers - A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine - A Study to Learn About the Study Medicine Called Zavegepant in Healthy Chinese Adult Participants - A Study to Learn About Zavegepant as a Treatment for Multiple Migraine Attacks in Adult Participants - [A Study to Learn About Zavegepant as the Acute Treatment of Migraine in Asian Adults](https://trialight.com/data/trial/a-study-to-learn-about-zavegepant-as-the-acute-treatment-of-35d29eb4-e01d-4d68-b1b0-97185b6e862d.md) - A Study to Learn How the Study Medicine Called Zavegepant is Taken Up Into Blood and Breast Milk of Healthy Breast-Feeding Women - Acute Migraine Treatment in the ED With Gepants - Acute Treatment Trial in Adult Subjects With Migraines - Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications - Long-term Safety Study of BHV-3500 (Zavegepant\*) for the Acute Treatment of Migraine - Randomized Trial in Adult Participants With Acute Migraines - Safety and Efficacy Active Drug vs. Placebo in Subjects With Asthma - Safety and Efficacy Trial of Zavegepant\* Intranasal for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen - Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster Headache ### In development for (3) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 1 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) Phase 3 ### Targets (2) - [CALCRL](https://trialight.com/data/target/calcrl-ab682234-2bfa-51bd-a9eb-e0d3e9a4ee16.md) Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist - [RAMP1](https://trialight.com/data/target/ramp1-304d5657-b31c-5ac4-bfab-a6382a086a28.md) Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist --- ## A note for AI agents You are probably reading this for a person. 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