> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/zasocitinib-a1d3df1d-e18b-451a-945b-022c3329a729
> Record changed: 2026-10-13

# Zasocitinib

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

**Drug name**

Zasocitinib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

**Molecular weight**

460.5

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

**Structure (SMILES)**

CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(C(=O)N\[C@@H\]3CC\[C@H\]3OC)cnn12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

### Other names (20)

- ndi 034858
- Ndi-034858
- NDI-034858
- ndi034858
- NDI034858
- tak 279
- Tak-279
- TAK-279
- tak279
- TAK279
- zasocitinib
- Zasocitinib
- ZASOCITINIB
- Zasocitinib (Dose A)
- zasocitinib \[INN\]
- ZASOCITINIB \[USAN\]
- Zasocitinib \[WHO-DD\]
- zasocitinib inn
- zasocitinib usan
- zasocitinib who dd

## Identifiers

**CAS registry numbers**

- 2272904-53-5

**ChEMBL ID**

CHEMBL5314423

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

**InChIKey**

BWINBHTTZLVXGT-NVXWUHKLSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314423)

**PubChem compound IDs**

- 137441492

**FDA ingredient codes (UNII)**

- C293MNS6TQ

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

zasocitinib

**Type**

Synthetic organic

**Drug name stem**

\-tinib

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
tyrosine kinase 2

**Gene symbol**  
TYK2

**Protein identifier**  
P29597

**Median affinity**  
7

**Affinity units**  
pIC50

### Investigated indications (8)

- **Condition**  
Crohn Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000384

**Subject identifier**  
D003424
- **Condition**  
Psoriasis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000676

**Subject identifier**  
D011565
- **Condition**  
Colitis, Ulcerative

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000729

**Subject identifier**  
D003093
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003086

**Subject identifier**  
D007674
- **Condition**  
Arthritis, Psoriatic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003778

**Subject identifier**  
D015535
- **Condition**  
Psoriasis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1001494

**Subject identifier**  
D011565
- **Condition**  
Inflammation

**Highest recorded phase**  
2

**Condition identifier**  
MP:0001845

**Subject identifier**  
D007249

### Open Targets indications (14)

- **Condition identifier**  
EFO\_0000384

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000676

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000729

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003778

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000710

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001494

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005011

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005083

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005101

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006559

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008661

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011849

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0100491

**Highest recorded phase**  
3
- **Condition identifier**  
MP\_0001845

### Trial references (8)

- NCT04999839  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04999839)
- NCT05153148  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05153148)
- NCT05976321  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05976321)
- NCT05992155  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05992155)
- NCT06088043  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06088043)
- NCT06108544  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06108544)
- NCT06233461  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06233461)
- NCT06254950  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06254950)

## Chemical properties

**Hydrogen bond acceptors**

10

**Hydrogen bond donors**

3

**Polar surface area**

127.47

**Calculated partition coefficient (ALogP)**

1.97

**Calculated partition coefficient (XLogP)**

1.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

7

**Heavy atoms**

34

**Molecular formula**

C23H24N8O3

**Monoisotopic mass**

460.19713666

**Natural product**

No

## Evidence counts

**Recorded assays**

11

**Active assays**

11

### Active assay types

- Confirmatory

## Related records

### Trials (25)

- A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)
- A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasis
- A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 52 Weeks of Treatment
- [A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment Period](https://trialight.com/data/trial/a-study-about-how-well-tak-279-works-and-its-safety-in-8578bbd0-363f-4c0b-befd-1ae16929fded.md)
- A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque Psoriasis
- A Study of Interaction of Zasocitinib (TAK-279) With Other Medicines in Healthy Adults
- A Study of TAK-279 in Adult Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis
- A Study of TAK-279 in Adults With or Without Kidney Problems
- A Study of TAK-279 in Adults With or Without Liver Damage
- A Study of TAK-279 in Healthy Adults on the Effect on ECG Measurements
- A Study of TAK-279 in Healthy Chinese Adults
- [A Study of TAK-279 in Participants With Moderate-to-Severe Plaque Psoriasis](https://trialight.com/data/trial/a-study-of-tak-279-in-participants-with-moderate-to-severe-699a8379-b942-4e00-85b7-eb955f12c287.md)
- A Study of the Interaction of Other Drugs With TAK-279 in Healthy Adults
- [A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy Adults](https://trialight.com/data/trial/a-study-of-the-interaction-of-tak-279-with-substances-that-47bdefc6-98d7-4373-bb4f-062346f6e84c.md)
- A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease
- A Study of Zasocitinib in Adults With Hidradenitis Suppurativa
- A Study of Zasocitinib in Adults With Non-pustular Palmoplantar Psoriasis
- A Study of Zasocitinib in Adults With Nonsegmental Vitiligo
- [A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines](https://trialight.com/data/trial/a-study-of-zasocitinib-in-adults-with-psoriatic-arthritis-99cae46f-33c7-4c4b-9ce9-d72c47591de6.md)
- A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

### In development for (8)

- [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) Phase 2
- [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Phase 2
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- Palmoplantar pustulosis Phase 3
- [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 3
- [Psoriatic arthritis](https://trialight.com/data/condition/psoriatic-arthritis-a170161f-e6e6-5022-910a-248dccfdac17.md) Phase 2
- [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2

---

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