> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/voriconazole-1d4648d7-4d92-4ae6-9eee-00ae8c143268 > Record changed: 2026-10-13 # Voriconazole Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) First approval year 2002 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) ## Development status **First approval year** 2002 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) **Drug name** Voriconazole Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) **Molecular weight** 349.32 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) **Structure (SMILES)** C\[C@@H\](c1ncncc1F)\[C@\](O)(Cn1cncn1)c1ccc(F)cc1F Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) ### Brand names (8) - vfend - Vfend - voriconazole - Voriconazole - voriconazole accord - Voriconazole accord - Voriconazole hikma (previously voriconazole hospira) - voriconazole hikma previously voriconazole hospira ### Other names (59) - (.ALPHA.R,.BETA.S)-A-(2,4-DIFLUOROPHENYL)-5-FLUORO-.BETA.-METHYL-.ALPHA.-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-4-PYRIMIDINEETHANOL - 4 pyrimidineethanol a 2 4 difluorophenyl 5 fluoro beta methyl alpha 1h 1 2 4 triazol 1 ylmethyl alpha r beta s - 4-PYRIMIDINEETHANOL, A-(2,4-DIFLUOROPHENYL)-5-FLUORO-.BETA.-METHYL-.ALPHA.-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-, (.ALPHA.R,.BETA.S)- - alpha r beta s a 2 4 difluorophenyl 5 fluoro beta methyl alpha 1h 1 2 4 triazol 1 ylmethyl 4 pyrimidineethanol - anidulafungin and voriconazole - Antifungal drug. VORICONAZOL. (VFEND®) - no voriconazole (Vfend) - nsc 759888 - NSC-759888 - oral voriconazole - uk 109 496 - uk 109496 - UK-109,496 - UK-109496 - Vaway FC Tablets 200mg (Voriconazole) - VFEND - Vfend (voriconazole) intravenous infusion - Vfend (voriconazole) tablet - VFEND FC Tablets 200mg (Voriconazole) - Vfend®(Voriconazole) IV 200mg - Vorico Injection 200mg(Voriconazole) - voriconazol - Voriconazol - voriconazole - Voriconazole And 34 more, listed on the interactive page. ## Identifiers **ATC classification codes** - J02AC03 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) **CAS registry numbers** - 137234-62-9 **ChEMBL ID** CHEMBL638 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) **InChIKey** BCEHBSKCWLPMDN-MGPLVRAMSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL638) **PubChem compound IDs** - 71616 **RxNorm IDs (RxCUI)** - 121243 **FDA ingredient codes (UNII)** - JFU09I87TR ## Regulatory information ### United States **Applicant** PF PRISM CV **Approval date** 24 May 2002 **Application number** NDA021266 ### European Union **Status** Authorised **Status date** 19 Mar 2002 **Authorisation date** 19 Mar 2002 **Approved indications** Voriconazole, is a broad spectrum, triazole antifungal agent and is indicated in adults and children aged 2 years and above as follows: treatment of invasive aspergillosis; treatment of in candidaemianon-neutropenic patients; treatment of fluconazole-resistant serious invasive Candida infections (including C. krusei); Treatment of serious fungal infections caused by Scedosporium spp. and Fusarium spp. Vfend should be administered primarily to patients with progressive, possibly life-threatening infections. Prophylaxis of invasive fungal infections in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipients. **Product number** EMEA/H/C/000387 **Authorisation holder** Pfizer Europe MA EEIG **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 2 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Aspergillosis - Candidiasis - Mycoses European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/vfend) ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Drug name stem** \-conazole #### Administration routes - Oral - Parenteral ### Mechanisms of action - **Mechanism** Cytochrome P450 51 inhibitor **Action type** Inhibitor **Target** Lanosterol 14-alpha demethylase **Protein identifier** P10613 ### Open Targets mechanisms - **Mechanism** Cytochrome P450 51 inhibitor **Action type** Inhibitor **Target** Lanosterol 14-alpha demethylase ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** ERG11 **Protein identifier** P10613 **Organism** Candida albicans (strain SC5314 / ATCC MYA-2876) ### Investigated indications (22) - **Condition** Bacterial Infections and Mycoses **Highest recorded phase** 4 **Subject identifier** D001423 - **Condition** Leukemia, Lymphocytic, Chronic, B-Cell **Highest recorded phase** 1 **Condition identifier** EFO:0000095 **Subject identifier** D015451 - **Condition** Myelodysplastic Syndromes **Highest recorded phase** 2 **Condition identifier** EFO:0000198 **Subject identifier** D009190 - **Condition** Leukemia, Myeloid, Acute **Highest recorded phase** 3 **Condition identifier** EFO:0000222 **Subject identifier** D015470 - **Condition** Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Leukemia **Highest recorded phase** 3 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** HIV Infections **Highest recorded phase** 1 **Condition identifier** EFO:0000764 **Subject identifier** D015658 - **Condition** Hematologic Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0001642 **Subject identifier** D019337 - **Condition** Leishmaniasis **Highest recorded phase** 3 **Condition identifier** EFO:0005044 **Subject identifier** D007896 - **Condition** Aspergillosis, Allergic Bronchopulmonary **Highest recorded phase** 2 **Condition identifier** EFO:0007140 **Subject identifier** D001229 - **Condition** Aspergillosis **Highest recorded phase** 4 **Condition identifier** EFO:0007157 **Subject identifier** D001228 - **Condition** Neuroaspergillosis **Highest recorded phase** 3 **Condition identifier** EFO:0007393 **Subject identifier** D020953 - **Condition** Keratitis **Highest recorded phase** 0.5 **Condition identifier** EFO:0009449 **Subject identifier** D007634 - **Condition** Candidemia **Highest recorded phase** 4 **Condition identifier** EFO:1001282 **Subject identifier** D058387 - **Condition** Candidiasis, Invasive **Highest recorded phase** 3 **Condition identifier** EFO:1001283 **Subject identifier** D058365 - **Condition** Fusariosis **Highest recorded phase** 4 **Condition identifier** EFO:1001795 **Subject identifier** D060585 - **Condition** Neutropenia **Highest recorded phase** 1 **Condition identifier** MONDO:0001475 **Subject identifier** D009503 - **Condition** Candidiasis **Highest recorded phase** 4 **Condition identifier** MONDO:0002026 **Subject identifier** D002177 - **Condition** Mycoses **Highest recorded phase** 4 **Condition identifier** MONDO:0002041 **Subject identifier** D009181 - **Condition** Asthma **Highest recorded phase** 1 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 - **Condition** Graft vs Host Disease **Highest recorded phase** 1 **Condition identifier** MONDO:0013730 **Subject identifier** D006086 ### Open Targets indications (53) - **Condition identifier** EFO\_0000095 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000222 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000544 - **Condition identifier** EFO\_0000544 **Highest recorded phase** 4 - **Condition identifier** EFO\_0000565 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001642 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004251 - **Condition identifier** EFO\_0005044 **Highest recorded phase** 3 - **Condition identifier** EFO\_0007140 - **Condition identifier** EFO\_0007157 - **Condition identifier** EFO\_0009260 - **Condition identifier** EFO\_1001282 - **Condition identifier** EFO\_1001282 **Highest recorded phase** 4 - **Condition identifier** EFO\_1001283 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001795 - **Condition identifier** EFO\_1002048 - **Condition identifier** HP\_0001945 **Highest recorded phase** 3 - **Condition identifier** HP\_0002105 **Highest recorded phase** 2 - **Condition identifier** HP\_0002863 - **Condition identifier** MONDO\_0000256 - **Condition identifier** MONDO\_0000256 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0000266 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001475 - **Condition identifier** MONDO\_0001475 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002026 And 28 more, listed on the interactive page. ### Reported adverse events (43) - **Event** actinic keratosis **Reports** 157 **Reporting signal score** 551.287 - **Event** aspergillosis **Reports** 32 **Reporting signal score** 101.185 - **Event** aspergillus infection **Reports** 162 **Reporting signal score** 521.116 - **Event** basal cell carcinoma **Reports** 76 **Reporting signal score** 93.0774 - **Event** bowen's disease **Reports** 71 **Reporting signal score** 238.172 - **Event** bronchopulmonary aspergillosis **Reports** 193 **Reporting signal score** 614.986 - **Event** cerebral aspergillosis **Reports** 35 **Reporting signal score** 141.069 - **Event** cholestasis **Reports** 164 **Reporting signal score** 265.062 - **Event** choroiditis **Reports** 39 **Reporting signal score** 153.41 - **Event** condition aggravated **Reports** 284 **Reporting signal score** 93.6242 - **Event** dilatation intrahepatic duct acquired **Reports** 33 **Reporting signal score** 140.643 - **Event** drug interaction **Reports** 660 **Reporting signal score** 740.915 - **Event** drug level below therapeutic **Reports** 79 **Reporting signal score** 178.983 - **Event** drug resistance **Reports** 118 **Reporting signal score** 145.932 - **Event** drug-induced liver injury **Reports** 93 **Reporting signal score** 86.757 - **Event** electrocardiogram qt prolonged **Reports** 113 **Reporting signal score** 90.351 - **Event** endophthalmitis **Reports** 63 **Reporting signal score** 120.442 - **Event** fatigue **Reports** 47 **Reporting signal score** 137.824 - **Event** fluoride increased **Reports** 37 **Reporting signal score** 202.747 - **Event** fluorosis **Reports** 22 **Reporting signal score** 114.554 - **Event** fungal infection **Reports** 89 **Reporting signal score** 102.603 - **Event** graft versus host disease **Reports** 54 **Reporting signal score** 104.715 - **Event** hallucination **Reports** 277 **Reporting signal score** 377.318 - **Event** hallucination, visual **Reports** 210 **Reporting signal score** 436.24 - **Event** hepatic function abnormal **Reports** 129 **Reporting signal score** 131.754 And 18 more, listed on the interactive page. ### Trial references (57) - NCT00001646 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001646) - NCT00001810 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001810) - NCT00003031 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00003031) - NCT00159822 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00159822) - NCT00412893 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00412893) - NCT00423163 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00423163) - NCT00531479 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00531479) - NCT00620074 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00620074) - NCT00836875 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00836875) - NCT01080651 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01080651) - NCT01188759 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01188759) - NCT01207128 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01207128) - NCT01383993 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01383993) - NCT01782131 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01782131) - NCT01887457 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01887457) - NCT02180165 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02180165) - NCT03327727 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03327727) - NCT03672292 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03672292) - NCT04824417 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04824417) - NCT00001757 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001757) - NCT00001940 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001940) - NCT00015665 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00015665) - NCT00136968 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00136968) - NCT00143312 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00143312) - NCT00150345 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00150345) And 32 more, listed on the interactive page. ## Dosing **Dose** 6 mg/kg **Route** Intravenous **How often** Every 12 hours for the first 24 hours, then every 12 hours afterwards ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 1 **Polar surface area** 76.72 **Calculated partition coefficient (ALogP)** 2.18 **Calculated partition coefficient (XLogP)** 1.5 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 25 **Molecular formula** C16H14F3N5O **Monoisotopic mass** 349.11504457 **Natural product** No ## National Drug Codes - 0049-3160 - 0049-3180 - 0049-3190 - 0049-4190 - 0121-1091 - 0378-1626 - 0378-1640 - 0781-3416 - 0781-5667 - 0781-5668 - 0904-6596 - 0904-7024 - 14335-730 - 16714-198 - 16714-199 - 27241-062 - 27241-063 - 31722-224 - 31722-266 - 40032-038 - 43386-038 - 43386-088 - 43386-089 - 43547-377 - 43547-378 And 32 more, listed on the interactive page. ## Evidence counts **Recorded assays** 4,623 **Active assays** 114 ### Active assay types (2) - Confirmatory - Screening ## Pharmacologic actions - Antifungal Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000935.html) - 14-alpha Demethylase Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D058888.html) - Cytochrome P-450 CYP3A Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D065692.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (527) - 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis - 5% Topical Ibuprofen (IBU) for Ankle Sprain - A Clinical Evaluation Pilot Study of the Efficacy of Blink® Tears Lubricant Eye Drops for the Relief of Dry Eye Symptoms Following Implantation of Tecnis® Multifocal Introcular Lens - A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood. - A Laser and Topical Treatment Combination in the Vulvo-vaginal Atrophy Management in Breast Cancer Patients. - A Multiple-Dose Study To Evaluate The Pharmacokinetics And Safety Of Voriconazole In Immunocompromised Adolescents - A New Hormone Replacement Paradigm: Physiologic Restoration Study - A Pharmacokinetic And Safety Study Of Voriconazole In Healthy Male And Female Adults - A Phase 1 Study to Assess Single and Multiple Ascending Doses of PBI-100 Topical Cream - A Phase 1b Study of ZYG24004 in Participants With Tinea Pedis Caused by Dermatophytes - A Phase 2 Study to Assess the Effectiveness of Topical Terbinafine in Participants With Mild to Moderate Onychomycosis of the Toenails - A Phase 3B, Open-label, Single-arm Study of the Efficacy and Safety of Apremilast, in Subjects With Plaque Psoriasis That is Not Adequately Controlled by Topical Therapy - A Phase II, Placebo Controlled, Clinical Trial of Topical TolaSure Targeting Aggregated Mutant Keratin in Epidermolysis Bullosa Simplex - A Phase IIb Safety and Efficacy Study of DE-126 Ophthalmic Solution in Primary Open-Angle Glaucoma or Ocular Hypertension- Angel Study - A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity - A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections - A Psoriasis Plaque Test Comparing Eight Different Formulations of Vitamin D Analogues for the Treatment of Psoriasis - A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients - A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome - A Randomized Controlled Trial to Compare the Clinical Outcomes With Six Months of Therapy With Oral Itraconazole Versus Oral Voriconazole for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis ### Approved for (5) - Aspergillosis - Candidemia - Candidiasis - Fungal infectious disease - Fusariosis ### In development for (15) - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 3 - Allergic bronchopulmonary aspergillosis Phase 2 - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 1 - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 1 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1 - Candidiasis, invasive Phase 3 - Graft versus host disease Phase 1 - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1 - Keratitis Early phase 1 - Leishmaniasis Phase 3 - [Leukemia](https://trialight.com/data/condition/leukemia-519aefcd-8521-5941-851b-5b77ca925ca5.md) Phase 3 - Lymphoid neoplasm Phase 1 - [Myelodysplastic syndrome](https://trialight.com/data/condition/myelodysplastic-syndrome-f5df8ce5-6064-53d3-902c-f09fc4acd4bb.md) Phase 2 - Neuroaspergillosis Phase 3 - Neutropenia Phase 1 ### Other linked conditions (3) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) - [Kidney failure](https://trialight.com/data/condition/kidney-failure-f26737b4-3a55-50be-b6c3-b76514cb5067.md) - Systemic mycosis --- ## A note for AI agents You are probably reading this for a person. 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