> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/volenrelaxin-ed511173-2d05-456a-8e05-69964d531b39
> Record changed: 2026-10-13

# Volenrelaxin

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068449)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068449)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068449)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068449)

**Drug name**

Volenrelaxin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068449)

### Other names (17)

- immunoglobulin g anti human serum albumin human lama glama γ chain v d j region fusion protein with peptide linker ggggq 5 fusion protein with 2 29 relaxin 2 human chain b fusion protein with peptide linker gggsggsggg fusion protein with relaxin 2 human chain a
- Immunoglobulin G, anti-(human serum albumin) (human-Lama glama γ-chain V-D-J region) fusion protein with peptide linker (GGGGQ)5 fusion protein with 2-29-relaxin 2 (human chain B) fusion protein with peptide linker (GGGSGGSGGG) fusion protein with relaxin 2 (human chain A)
- ly 3540378
- LY-3540378
- ly3540378
- Ly3540378
- LY3540378
- volenrelaxin
- Volenrelaxin
- volenrelaxin \[INN\]
- VOLENRELAXIN \[USAN\]
- volenrelaxin inn
- volenrelaxin usan
- volenrelaxina
- Volenrelaxina
- volenrelaxine
- Volenrelaxine

## Identifiers

**CAS registry numbers**

- 2653949-19-8

**ChEMBL ID**

CHEMBL6068449

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068449)

**FDA ingredient codes (UNII)**

- TVT9XLV5MU

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Investigated indications (3)

- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Respiratory Tract Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000684

**Subject identifier**  
D012140
- **Condition**  
Kidney Diseases

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000077

**Subject identifier**  
D007674

### Open Targets indications (7)

- **Condition identifier**  
EFO\_0000319
- **Condition identifier**  
EFO\_0000684
- **Condition identifier**  
EFO\_0003884

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000077
- **Condition identifier**  
MONDO\_0004995
- **Condition identifier**  
MONDO\_0005087
- **Condition identifier**  
MONDO\_0005300

**Highest recorded phase**  
2

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (3)

- A Study of LY3540378 in Healthy Participants
- [A Study of LY3540378 in Participants With Worsening Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)](https://trialight.com/data/trial/a-study-of-ly3540378-in-participants-with-worsening-chronic-fecc8808-1204-4f78-ba59-2e9da9ff0485.md)
- Efficacy and Safety of Volenrelaxin in Adults With Chronic Kidney Disease

### In development for (4)

- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1
- [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 2
- [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 1
- Respiratory system disorder Phase 1

---

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