> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/vixarelimab-7b5d32ea-5bbc-48b3-9222-287920c29a27
> Record changed: 2026-10-13

# Vixarelimab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594341)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594341)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594341)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594341)

**Drug name**

Vixarelimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594341)

### Other names (20)

- 30C6 (N73D) IGG4P.AGLY/IGG1
- 30C6 \[N73D) IgG4P.agly/IgG1
- 30c6 n73d igg4p agly igg1
- biib 069
- BIIB-069
- biib069
- BIIB069
- IMMUNOGLOBULIN G (234-PROLINE,303-GLUTAMINE), ANTI-(HUMAN ONCOSTATIN M RECEPTOR SUBUNIT .BETA.) (HUMAN MONOCLONAL KPL-716 .GAMMA.-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL KPL-716 .LAMBDA.-CHAIN, DIMER
- immunoglobulin g 234 proline 303 glutamine anti human oncostatin m receptor subunit beta human monoclonal kpl 716 gamma chain disulfide with human monoclonal kpl 716 lambda chain dimer
- kpl 716
- Kpl-716
- KPL-716
- vixarelimab
- Vixarelimab
- vixarelimab \[INN\]
- VIXARELIMAB \[USAN\]
- Vixarelimab \[WHO-DD\]
- vixarelimab inn
- vixarelimab usan
- vixarelimab who dd

## Identifiers

**CAS registry numbers**

- 2243320-83-2

**ChEMBL ID**

CHEMBL4594341

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594341)

**FDA ingredient codes (UNII)**

- W25GO3A75W

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

vixarelimab

**Type**

Antibody

**Drug name stem**

\-mab

### Mechanisms of action (2)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
Oncostatin M-specific receptor, β subunit

**Gene symbol**  
OSMR

**Protein identifier**  
Q99650
- **Mechanism**  
Oncostatin-M-specific receptor subunit beta inhibitor

**Action type**  
Inhibitor

**Target**  
Oncostatin-M-specific receptor subunit beta

**Protein identifier**  
Q99650

### Open Targets mechanisms

- **Mechanism**  
Oncostatin-M-specific receptor subunit beta inhibitor

**Action type**  
Inhibitor

**Target**  
Oncostatin-M-specific receptor subunit beta

### Investigated indications (2)

- **Condition**  
Colitis, Ulcerative

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000729

**Subject identifier**  
D003093
- **Condition**  
Pruritus

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000989

**Subject identifier**  
D011537

### Open Targets indications (13)

- **Condition identifier**  
EFO\_0000274

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000729

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000768

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001494

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000989

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0000989

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005101

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006572

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006585

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015925

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0026045

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0044212

**Highest recorded phase**  
2

### Trial references

- NCT06137183  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06137183)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (3)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYEINWVRQATGQGLEWMGWMNPNSGYTGYAQKFQGRVTMTRDTSISTAYMEMSSLRSEDTAVYYCARDIVAANTDYYFYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
QSVLTQPPSASGTPGQRVTISCSGSNSNIGSNTVNWYHQLPGTAPKLLIYNINKRPSGVPDRFSGSKSGSSASLAISGLQSEDEADYYCSTWDDSLDGVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
- **Component**  
Disulfide bridges

**Sequence**  
22'-89' $ 22'''-89''' $ 22-96 $ 22''-96'' $ 138'-197' $ 138'''-197''' $ 140-215'' $ 140''-215''' $ 153-209 $ 153''-209'' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431''

## Related records

### Trials (5)

- [A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease](https://trialight.com/data/trial/a-study-evaluating-the-efficacy-and-safety-of-vixarelimab-in-d88e1e3f-c24a-45e5-9c7e-eaaadd9ab6d1.md)
- A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases
- A Study to Evaluate the Activity, and Safety of Vixarelimab in Participants With Moderate to Severe Active Ulcerative Colitis
- A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vixarelimab in Participants With Moderate to Severe Ulcerative Colitis (UC)
- Study to Assess the Efficacy, Safety, and Tolerability of Vixarelimab in Reducing Pruritus in Prurigo Nodularis

### In development for (2)

- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 1
- [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2

### Targets (1)

- [OSMR](https://trialight.com/data/target/osmr-ad9e3f2e-aff9-5858-bcfb-d4fccaa5eca7.md) Oncostatin-M-specific receptor subunit beta inhibitor

---

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