> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/vicadrostat-7e95bddf-6ce5-48b1-88bd-2f85390cb67c > Record changed: 2026-10-13 # Vicadrostat Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) **Drug name** Vicadrostat Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) **Molecular weight** 317.73 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) **Structure (SMILES)** C\[C@\]1(CO)Cc2ncn(-c3ccc(C#N)c(Cl)c3)c2C(=O)O1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) ### Other names (9) - bi 690517 vicadrostat 10 mg qd empagliflozin 10 mg qd - bi690517 - BI690517 - vicadrostat - Vicadrostat - vicadrostat \[INN\] - VICADROSTAT \[USAN\] - vicadrostat inn - vicadrostat usan ## Identifiers **CAS registry numbers** - 1868065-21-7 **ChEMBL ID** CHEMBL6068035 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) **InChIKey** MCVIVPZYYMNCAW-OAHLLOKOSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068035) **PubChem compound IDs** - 118676295 **FDA ingredient codes (UNII)** - AF4VW4GA3H ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** vicadrostat **Type** Synthetic organic **Drug name stem** \-stat ### Mechanisms of action (2) - **Action** Inhibition **Action type** Inhibitor **Target** CYP11B1 **Gene symbol** CYP11B1 **Protein identifier** P15538 **Median affinity** 5.33 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** CYP11B2 **Gene symbol** CYP11B2 **Protein identifier** P19099 **Median affinity** 7.8 **Affinity units** pIC50 ### Open Targets indications (5) - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005016 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005252 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005300 **Highest recorded phase** 3 ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 1 **Polar surface area** 88.14 **Calculated partition coefficient (ALogP)** 1.86 **Calculated partition coefficient (XLogP)** 1.8 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 2 **Heavy atoms** 22 **Molecular formula** C15H12ClN3O3 **Monoisotopic mass** 317.0567189 **Natural product** No ## Related records ### Trials (8) - A Study in Healthy Men to Compare the Amount of Vicadrostat and Empagliflozin in the Blood When Taken Separately and Together - A Study in Healthy People to Test How 2 Different Formulations of a Combination Treatment (Vicadrostat and Empagliflozin) Are Taken up in the Body and How Food Influences the Amount of the Medicines in the Blood - A Study in Healthy People to Test How Vicadrostat Affects the Heart - [A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart](https://trialight.com/data/trial/a-study-to-test-whether-vicadrostat-bi-690517-in-combination-7cbfb541-7608-404c-91ea-4ed907d5adad.md) - [A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease](https://trialight.com/data/trial/a-study-to-test-whether-vicadrostat-in-combination-with-2b73bf3b-968d-43fd-ada4-ce2f239df64e.md) - [A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure](https://trialight.com/data/trial/a-study-to-test-whether-vicadrostat-in-combination-with-63decdc9-f78b-46e4-9b99-2de3b50489ac.md) - Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS) - [EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease](https://trialight.com/data/trial/easi-protkttm-a-study-to-test-vicadrostat-bi-690517-taken-761742d0-ab53-4562-a44f-cfb5883ff489.md) --- ## A note for AI agents You are probably reading this for a person. 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