Vicadrostat

Highest phase reached
Phase 2
www.ebi.ac.uk
Drug type
Small molecule
www.ebi.ac.uk

Listing at source
Listed
Highest phase reached
Phase 2
www.ebi.ac.uk

Drug type
Small molecule
www.ebi.ac.uk
Drug name
Vicadrostat
www.ebi.ac.uk
Molecular weight
317.73
www.ebi.ac.uk
Structure (SMILES)
C[C@]1(CO)Cc2ncn(-c3ccc(C#N)c(Cl)c3)c2C(=O)O1
www.ebi.ac.uk

  • bi 690517 vicadrostat 10 mg qd empagliflozin 10 mg qd
  • bi690517
  • BI690517
  • vicadrostat
  • Vicadrostat
  • vicadrostat [INN]
  • VICADROSTAT [USAN]
  • vicadrostat inn
  • vicadrostat usan

CAS registry numbers
  • 1868065-21-7
ChEMBL ID
CHEMBL6068035
www.ebi.ac.uk
InChIKey
MCVIVPZYYMNCAW-OAHLLOKOSA-N
www.ebi.ac.uk
PubChem compound IDs
  • 118676295
FDA ingredient codes (UNII)
  • AF4VW4GA3H

First in class
No
Orphan designation
No

Pharmacology name
vicadrostat
Type
Synthetic organic
Drug name stem
-stat

  • Action
    Inhibition
    Action type
    Inhibitor
    Target
    CYP11B1
    Gene symbol
    CYP11B1
    Protein identifier
    P15538
    Median affinity
    5.33
    Affinity units
    pIC50
  • Action
    Inhibition
    Action type
    Inhibitor
    Target
    CYP11B2
    Gene symbol
    CYP11B2
    Protein identifier
    P19099
    Median affinity
    7.8
    Affinity units
    pIC50

  • Condition identifier
    MONDO_0004995
    Highest recorded phase
    2
  • Condition identifier
    MONDO_0005016
    Highest recorded phase
    1
  • Condition identifier
    MONDO_0005148
    Highest recorded phase
    2
  • Condition identifier
    MONDO_0005252
    Highest recorded phase
    3
  • Condition identifier
    MONDO_0005300
    Highest recorded phase
    3

Hydrogen bond acceptors
6
Hydrogen bond donors
1
Polar surface area
88.14
Calculated partition coefficient (ALogP)
1.86
Calculated partition coefficient (XLogP)
1.8
Prodrug
No
Chirality
Single enantiomer
Inorganic
No
Rule-of-five violations
0
Rotatable bonds
2
Heavy atoms
22
Molecular formula
C15H12ClN3O3
Monoisotopic mass
317.0567189
Natural product
No

Related records

Trials (8)