> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/vibostolimab-4e76246e-3125-402c-8952-6ae00d17aeb3
> Record changed: 2026-10-13

# Vibostolimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297785)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297785)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297785)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297785)

**Drug name**

Vibostolimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297785)

### Brand names (2)

- vibostolimab component of mk 7684a
- Vibostolimab component of mk-7684a

### Other names (26)

- immunoglobulin g1 anti human receptor tigit t cell immunoreceptor with ig and itim domains human mus musculus monoclonal c011 gamma 1 chain disulfide with human mus musculus monoclonal c011 kappa chain dimer
- immunoglobulin g1 kappa anti homo sapiens t cell immunoreceptor with ig and itim domains v set and immunoglobulin domain containing protein 9 v set and transmembrane domain containing protein 3 humanized monoclonal antibody gamma 1 heavy chain humanized 1 449 vh homo sapiens ighv1 69 08 85 ighd ighj3 01 93 8 8 12 1 119 homo sapiens ighg1 01 100 120 449 222 214 disulfide with kappa light chain humanized 1 214 v kappa homo sapiens igkv1 27 01 85 igkj5 01 92 6 3 9 1 107 homo sapiens igkc 01 100 108 214 dimer 228 228 231 231 bisdisulfide
- IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS, V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 9, V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3)HUMANIZED MONOCLONAL ANTIBODY.GAMMA.1 HEAVY CHAIN HUMANIZED (1-449) (VH (HOMO SAPIENS IGHV1-69\*08 (85%) (IGHD)-IGHJ3\*01 (93%)) (8.8.12) (1-119)-HOMO SAPIENS IGHG1\*01 (100%) (120-449)) (222-214')-DISULFIDE WITH .KAPPA. LIGHT CHAIN HUMANIZED (1'-214') (V-KAPPA (HOMO SAPIENS IGKV1-27\*01 (85%) IGKJ5\*01 (92%))(6.3.9) (1'-107')-HOMO SAPIENS IGKC\*01 (100%) (108'-214')), DIMER (228-228'':231-231'')-BISDISULFIDE
- IMMUNOGLOBULIN G1, ANTI-(HUMAN RECEPTOR TIGIT (T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS)) (HUMAN-MUS MUSCULUS MONOCLONAL C011 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL C011 .KAPPA.-CHAIN, DIMER
- mk 7684
- mk 7684a component vibostolimab
- Mk-7684
- MK-7684
- MK-7684A COMPONENT VIBOSTOLIMAB
- mk7684
- MK7684
- pembrolizumab vibostolimab
- t cell immunoglobulin and immunoreceptor tyrosine based inhibitory motif inhibitor mk 7684
- T-CELL IMMUNOGLOBULIN AND IMMUNORECEPTOR TYROSINE-BASED INHIBITORY MOTIF INHIBITOR MK-7684
- tigit inhibitor mk 7684
- TIGIT INHIBITOR MK-7684
- tigit targeting agent mk 7684
- TIGIT-TARGETING AGENT MK-7684
- vibostolimab
- Vibostolimab
- vibostolimab \[INN\]
- VIBOSTOLIMAB \[USAN\]
- Vibostolimab \[WHO-DD\]
- vibostolimab inn
- vibostolimab usan

And 1 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2231305-30-7

**ChEMBL ID**

CHEMBL4297785

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297785)

**FDA ingredient codes (UNII)**

- 5XO3JF0FEK

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
T-cell immunoreceptor with Ig and ITIM domains antagonist

**Action type**  
Antagonist

**Target**  
T-cell immunoreceptor with Ig and ITIM domains

**Protein identifier**  
Q495A1

### Open Targets mechanisms

- **Mechanism**  
T-cell immunoreceptor with Ig and ITIM domains antagonist

**Action type**  
Antagonist

**Target**  
T-cell immunoreceptor with Ig and ITIM domains

### Investigated indications (11)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Hematologic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001642

**Subject identifier**  
D019337
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Neoplasm Metastasis

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0009708

**Subject identifier**  
D009362
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005575

**Subject identifier**  
D015179
- **Condition**  
Lung Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0021117

**Subject identifier**  
D008175

### Open Targets indications (17)

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000756

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001642

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004703

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005005

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005086

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005157

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008903

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0009348

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0040679

**Highest recorded phase**  
1

### Reported adverse events

- **Event**  
microvascular coronary artery disease

**Reports**  
2

**Reporting signal score**

21.311

### Trial references (17)

- NCT02625961  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02625961)
- NCT02964013  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02964013)
- NCT04165070  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04165070)
- NCT04725188  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04725188)
- NCT04738487  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04738487)
- NCT05226598  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05226598)
- NCT05298423  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05298423)
- NCT04303169  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04303169)
- NCT04305041  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04305041)
- NCT04305054  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04305054)
- NCT05665595  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05665595)
- NCT04626479  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04626479)
- NCT04895722  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04895722)
- NCT05005442  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05005442)
- NCT05224141  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05224141)
- NCT05845814  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05845814)
- NCT06395090  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06395090)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVQSGAEVKKPGSSVKVSCKASGYTFSSYVMHWVRQAPGQGLEWIGYIDPYNDGAKYAQKFQGRVTLTSDKSTSTAYMELSSLRSEDTAVYYCARGGPYGWYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCRASEHIYSYLSWYQQKPGKVPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQHHFGSPLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-299 $ Asn-299''''
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 146-202 $ 146''-202'' $ 214'-222 $ 214'''-222'' $ 228-228'' $ 231-231'' $ 263-323 $ 263''-323'' $ 369-427 $ 369''-427''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-299 $ Asn-299''

## Related records

### Trials (17)

- [A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)](https://trialight.com/data/trial/a-study-of-adjuvant-pembrolizumab-vibostolimab-mk-7684a-bc27363c-59d6-4d88-b245-89b041aa6388.md)
- [A Study of Efficacy and Safety of Pembrolizumab Plus Enfortumab Vedotin (EV) +/- Investigational Agents in First-Line Metastatic Urothelial Carcinoma (mUC) (MK-3475-04B/KEYMAKER-U04)](https://trialight.com/data/trial/a-study-of-efficacy-and-safety-of-pembrolizumab-plus-48b8dafa-2b39-4868-b35c-ff8a4b43b198.md)
- A Study of Pembrolizumab in Combination With Investigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01B/LIGHTBEAM-U01)
- A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004, KEYVIBE-004)
- Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)
- Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).
- KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
- Pembrolizumab/Vibostolimab Coformulation (MK-7684A) or Pembrolizumab/Vibostolimab Coformulation Plus Docetaxel Versus Docetaxel for Metastatic Non Small Cell Lung Cancer (NSCLC) With Progressive Disease After Platinum Doublet Chemotherapy and Immunotherapy (MK-7684A-002, KEYVIBE-002)
- Study of Pembrolizumab (MK-3475) and Pembrolizumab With Other Investigational Agents in Participants With High Risk Non-muscle Invasive Bladder Cancer (MK-3475-057/KEYNOTE-057)
- Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)
- Study of Pembrolizumab/Vibostolimab (MK-7684A) in Combination With Concurrent Chemoradiotherapy Followed by Pembrolizumab/Vibostolimab Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Stage III Non-small Cell Lung Cancer (MK-7684A-006)
- Study of Pembrolizumab/Vibostolimab Coformulation (MK-7684A) in Combination With Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (MK-7684A-007/KEYVIBE-007)
- Study of Vibostolimab Alone and in Combination With Pembrolizumab in Advanced Solid Tumors (MK-7684-001) ( KEYVIBE-001)
- Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)
- Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)
- Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)
- Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

### In development for (11)

- [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2
- [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 3
- [Lung neoplasm](https://trialight.com/data/condition/lung-neoplasm-d4ce75ac-7517-5ab7-9f47-34c0f7b81786.md) Phase 3
- Lymphoid neoplasm Phase 2
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 3
- Neoplasm Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3
- [Renal cell carcinoma](https://trialight.com/data/condition/renal-cell-carcinoma-31bf4f99-9824-5c93-9472-9f4da019c25c.md) Phase 1
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 3
- Urinary bladder cancer Phase 2
- [Urothelial carcinoma](https://trialight.com/data/condition/urothelial-carcinoma-b2aa266d-2d5f-5e5d-a0de-62274f2dc094.md) Phase 2

### Targets (1)

- [TIGIT](https://trialight.com/data/target/tigit-3420020b-537a-54b3-8cbf-76103a59da64.md) T-cell immunoreceptor with Ig and ITIM domains antagonist

---

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