> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/vericiguat-b2b194dc-6954-464b-a8d5-89d20e5ae21c > Record changed: 2026-10-13 # Vericiguat Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) First approval year 2021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) ## Development status **First approval year** 2021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) **Drug name** Vericiguat Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) **Molecular weight** 426.39 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) **Structure (SMILES)** COC(=O)Nc1c(N)nc(-c2nn(Cc3ccccc3F)c3ncc(F)cc23)nc1N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) ### Brand names (2) - verquvo - Verquvo ### Other names (28) - bay 1021189 - BAY 1021189 - BAY-1021189 - mk 1242 - MK-1242 - vericiguat - Vericiguat - vericiguat (BAY 1021189) - Vericiguat (BAY1021189) - Vericiguat (BAY1021189) (1.25 mg) - Vericiguat (BAY1021189) (5 mg) - Vericiguat (BAY1021189) 5 mg - Vericiguat \[INN\] - Vericiguat \[JAN\] - Vericiguat \[MI\] - Vericiguat \[ORANGE BOOK\] - Vericiguat \[USAN\] - Vericiguat \[WHO-DD\] - Vericiguat 10 MG - vericiguat inn - vericiguat jan - vericiguat mi - Vericiguat Oral Tablet - vericiguat orange book - Vericiguat suspension And 3 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 1350653-20-1 **ChEMBL ID** CHEMBL4066936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) **InChIKey** QZFHIXARHDBPBY-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) **PubChem compound IDs** - 54674461 **RxNorm IDs (RxCUI)** - 2475830 **FDA ingredient codes (UNII)** - LV66ADM269 ### ATC classification codes (2) - C01 - C01DX22 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4066936) ## Regulatory information ### United States **Applicant** MSD **Approval date** 19 Jan 2021 **Application number** NDA214377 ### European Union **Status** Authorised **Status date** 16 Jul 2021 **Authorisation date** 16 Jul 2021 **Approved indications** Treatment of symptomatic chronic heart failure **Product number** EMEA/H/C/005319 **Authorisation holder** Bayer AG **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Heart Failure European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/verquvo) ### Other regulatory facts **Patents** 6 **Designations** 2 **Earliest recorded loss of exclusivity** 26 Nov 2032 **First in class** Yes **Fast track** Yes **Breakthrough designation** No **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Pharmacology ### Drug classification **Pharmacology name** vericiguat **Type** Synthetic organic **Drug name stem** \-ciguat **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (7) - **Action** Activation **Action type** ACTIVATION **Target** Guanylyl cyclase, α2β1 **Gene symbol** GUCY1A2 **Protein identifier** P33402 - **Action** Activation **Action type** ACTIVATION **Target** Guanylyl cyclase, α1β1 **Gene symbol** GUCY1A1 **Protein identifier** Q02108 - **Action** Activation **Action type** ACTIVATION **Target** Guanylyl cyclase, α1β1 **Gene symbol** GUCY1B1 **Protein identifier** Q02153 - **Mechanism** Soluble guanylate cyclase activator **Action type** ACTIVATOR **Target** Soluble guanylate cyclase **Protein identifier** O75343 - **Mechanism** Soluble guanylate cyclase activator **Action type** ACTIVATOR **Target** Soluble guanylate cyclase **Protein identifier** P33402 - **Mechanism** Soluble guanylate cyclase activator **Action type** ACTIVATOR **Target** Soluble guanylate cyclase **Protein identifier** Q02108 - **Mechanism** Soluble guanylate cyclase activator **Action type** ACTIVATOR **Target** Soluble guanylate cyclase **Protein identifier** Q02153 ### Open Targets mechanisms - **Mechanism** Soluble guanylate cyclase activator **Action type** ACTIVATOR **Target** Soluble guanylate cyclase ### DrugCentral mechanisms - **Action type** ACTIVATOR **Gene symbol** GUCY1B3 **Protein identifier** Q02153 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (3) - **Condition** Cardiovascular Diseases **Highest recorded phase** 4 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Coronary Disease **Highest recorded phase** 1 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Heart Failure **Highest recorded phase** 4 **Condition identifier** EFO:0003144 **Subject identifier** D006333 ### Open Targets indications (8) - **Condition identifier** EFO\_0000319 - **Condition identifier** EFO\_0001645 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003144 - **Condition identifier** HP\_0000855 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004995 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005010 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005252 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005356 **Highest recorded phase** 2 ### Warnings - **Warning** Black Box Warning **Effect** teratogenicity ### Open Targets warnings - **Warning** Black Box Warning **Effect** teratogenicity **Country** United States ### Reported adverse events - **Event** cardiac failure **Reports** 4 **Reporting signal score** 12.8117 ### Trial references (11) - NCT01951625 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01951625) - NCT01951638 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01951638) - NCT03547583 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03547583) - NCT04722484 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04722484) - NCT04722562 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04722562) - NCT05086952 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05086952) - NCT05704478 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05704478) - NCT02617550 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02617550) - NCT03255512 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03255512) - NCT03504982 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03504982) - NCT06415227 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06415227) ## Dosing **Dose** 2.5-5mg **Route** Oral **How often** Once daily ### Conditions of use - Take with food ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 3 **Polar surface area** 146.86 **Calculated partition coefficient (ALogP)** 2.56 **Calculated partition coefficient (XLogP)** 1.5 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 4 **Heavy atoms** 31 **Molecular formula** C19H16F2N8O2 **Monoisotopic mass** 426.13642811 **Natural product** No ## National Drug Codes - 0006-5028 - 0006-5029 - 0006-5030 ## Evidence counts **Recorded assays** 51 **Active assays** 11 ### Active assay types - Confirmatory ## Biological measurements ### Observed measurements #### Oral bioavailability **Median** 70 **Mean** 70 **Minimum** 65 **Maximum** 75 **Unit** % **Assays** 2 **Standard deviation** 7.07107 **Summary method** median **Censored results excluded** 0 **Other units excluded** 0 **Unknown units excluded** 0 #### Measurement types - F ## Related records ### Trials (43) - A Study in Healthy Adult Male Participants to Learn the Way Vericiguat is Absorbed With and Without Food When Taken as a Single Dose in Liquid Form Suitable for Children Compared to a 10 Milligram (mg) Tablet That Releases the Active Substance Immediately - A Study of Real-world Events of Vericiguat in Patients With Chronic Kidney Disease and Heart Failure - [A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)](https://trialight.com/data/trial/a-study-of-vericiguat-mk-1242-in-participants-with-chronic-8182feb5-1a63-4ab0-accf-a3b1cdbd6772.md) - A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001) - A Study of Vericiguat in People With Breast Cancer and Cancer Therapy-Related Cardiac Dysfunction - A Study to Learn How Safe Starting Vericiguat at a Dose of 5 Milligrams is in Participants With Chronic Heart Failure With Reduced Ejection Fraction - A Study to Learn How Well the Drug Vericiguat Works and How Safe it is Under Real World Conditions in Indian Participants After Worsening of a Long-term Heart Condition in Which the Left Side of the Heart Does Not Pump Blood as Well as it Should (Chronic Heart Failure With Reduced Ejection Fraction) - A Study to Learn More About the Safety of the Drug Vericiguat in Japanese People With Chronic Heart Failure Who Will be Receiving Vericiguat Under Real-world Conditions - A Trial to Learn How Safe Vericiguat (BAY1021189) is and the Way the Body Absorbs, Distributes and Gets Rid of Vericiguat in Participants With Kidney Disease and in Age-, Weight- and Gender-matched Healthy Participants - A Trial to Learn How Safe Vericiguat (BAY1021189) is and the Way the Body Absorbs, Distributes and Gets Rid of Vericiguat in Participants With Liver Disease and in Age-, Weight- and Gender-matched Healthy Participants - An Observational Study Called ROVER to Learn More About How Well Vericiguat Works in People Who Were Newly Treated With Vericiguat in Routine Medical Care in Germany - An Observational Study to Learn More About How Safe Vericiguat is and How Well it Works in Indian People With Chronic Heart Failure With Reduced Ejection Fraction and Worsening Chronic Heart Failure Under Real World Conditions - An Observational Study to Learn More About the Real-world Outcomes in Patients With Heart Failure Who Initiate Treatment With Vericiguat in Japan - An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting - An Observational Study to Learn More About Vericiguat Treatment Patterns and Its Safety in People With Chronic Heart Failure With Reduced Ejection Fraction in Routine Medical Care in the United States - An Observational Study, Called VERI-China, to Learn More About How Well Vericiguat Works and How Safe it is in Real-world Setting in People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in China - COgnitioN With VERiciGuat Evaluation in Heart Failure - Comparing the Efficacy and Safety of Vericiguat With Standard Medical Treatment in Heart Failure Patients - Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction - Efficacy of Verciguat in TR and RV Failure ### Approved for (2) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) ### In development for (1) - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 1 ### Targets (4) - [GUCY1A1](https://trialight.com/data/target/gucy1a1-fa373a9a-c82a-51bf-a065-1bf847618dea.md) Soluble guanylate cyclase activator - [GUCY1A2](https://trialight.com/data/target/gucy1a2-84659966-fdab-54c1-bbcb-f1a403932799.md) Soluble guanylate cyclase activator - [GUCY1B1](https://trialight.com/data/target/gucy1b1-efb171f0-be14-51e9-bd71-b4b02145719c.md) Soluble guanylate cyclase activator - [GUCY1B2](https://trialight.com/data/target/gucy1b2-58818a23-8aae-525d-859d-88e1d5adf01d.md) Soluble guanylate cyclase activator --- ## A note for AI agents You are probably reading this for a person. 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