> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/verekitug-e3db55f1-2c3f-4a92-a600-d0cf8783b133 > Record changed: 2026-10-13 # Verekitug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315002) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315002) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315002) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315002) **Drug name** Verekitug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315002) ### Other names (22) - asp 7266 - ASP-7266 - asp7266 - ASP7266 - ASP7266 (HUMAN MONOCLONAL IGG1 AGAINST THYMIC STROMAL LYMPHOPOIETIN RECEPTOR (TSLPR)) - asp7266 human monoclonal igg1 against thymic stromal lymphopoietin receptor tslpr - immunoglobulin g1 anti human and macaca fascicularis cytokine receptor like factor 2 human monoclonal upb 101 γ1 chain disulfide with human monoclonal upb 101 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens crlf2 cytokine receptor like factor 2 tslpr thymic stromal lymphopoietin receptor homo sapiens monoclonal antibody - Immunoglobulin G1-kappa, anti-\[Homo sapiens CRLF2 (cytokine receptor like factor 2, TSLPR, thymic stromal lymphopoietin receptor)\], Homo sapiens monoclonal antibody - Immunoglobulin G1, anti-(human and Macaca fascicularis cytokine receptor-like factor 2) (human monoclonal UPB-101 γ1-chain), disulfide with human monoclonal UPB-101 κ-chain, dimer - trab 1 - TRAB-1 - upb 101 - Upb-101 - UPB-101 - verekitug - Verekitug - Verekitug (UPB-101) - verekitug \[INN\] - VEREKITUG \[USAN\] - verekitug inn - verekitug usan ## Identifiers **CAS registry numbers** - 2768386-15-6 **ChEMBL ID** CHEMBL5315002 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315002) **FDA ingredient codes (UNII)** - T1NAO7YDA7 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (2) - **Condition** Asthma **Highest recorded phase** 1 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 - **Condition** Inflammation **Highest recorded phase** 2 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (5) - **Condition identifier** EFO\_0000341 **Highest recorded phase** 2 - **Condition identifier** EFO\_1002029 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005002 **Highest recorded phase** 2 - **Condition identifier** MP\_0001845 ### Trial references - NCT05448651 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05448651) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLLESGGGLVQPGGSLRLSCAASGFTFRSSAMHWVRQAPGKGLKWVSSVSGSGAGTYYADSVKGRFTISRDNPKNTLYLQMNSLRAEDTAVYYCVKEGGSRGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQDISNYLAWFQQKPGKAPKSLIYTASSLQSGVPSKFSGSGSGTDFTLTISSLQPEDFATYYCQQYNLYPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 145-201 $ 145''-201'' $ 221-214' $ 221''-214''' $ 227-227'' $ 230-230'' $ 262-322 $ 262''-322'' $ 368-426 $ 368''-426'' - **Component** Glycosylation sites (N) **Sequence** 298 $ 298'' ## Related records ### Trials (6) - [A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)](https://trialight.com/data/trial/a-long-term-safety-and-efficacy-study-of-verekitug-upb-101-0c5d5fd2-18d2-422c-bdd6-19d8f2ce618f.md) - [A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD](https://trialight.com/data/trial/a-study-to-assess-the-efficacy-and-safety-of-verekitug-in-7ffd36d3-3b1d-4dc6-a3a1-220323379667.md) - [A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)](https://trialight.com/data/trial/a-study-to-investigate-the-efficacy-and-safety-of-verekitug-2abed9dc-25da-414b-9c0f-b1fb34b8a869.md) - A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal Polyps - Safety and Biologic Impact (Pharmacodynamics) of Repeated Injections and Increasing Amounts of UPB-101 in Asthmatics - Safety and Blood Levels After a Single Injection of UPB-101 in Healthy Japanese and Non-Japanese Non-East Asian Adults ### In development for (2) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 1 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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