> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/vedotin-84e7df1f-0a49-4f9e-90a9-066b794a9292 > Record changed: 2026-11-04 # Vedotin Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) **Drug name** Vedotin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) **Molecular weight** 1,318.67 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) **Structure (SMILES)** CC\[C@H\](C)\[C@@H\](\[C@@H\](CC(=O)N1CCC\[C@H\]1\[C@H\](OC)\[C@@H\](C)C(=O)N\[C@H\](C)\[C@@H\](O)c1ccccc1)OC)N(C)C(=O)\[C@@H\](NC(=O)\[C@H\](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)\[C@H\](CCCNC(N)=O)NC(=O)\[C@@H\](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) ### Other names (19) - conjugated form of mc vc pab mmae - conjugated form of mc-vc-PAB-MMAE - mmae - MMAE - monomethyl auristatin e - MONOMETHYL AURISTATIN E - monomethylauristatin e - Monomethylauristatin e - pab mmae - PAB-MMAE - sgd 1010 - SGD-1010 - vedotin - Vedotin - Vedotin (fragment) - vedotin fragment - Vedotin fragment - vedotin radical - Vedotin radical ## Identifiers **ChEMBL ID** CHEMBL4594216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) **InChIKey** IEDXPSOJFSVCKU-HOKPPMCLSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594216) **PubChem compound IDs** - 129198981 ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** telisotuzumab vedotin **Type** Antibody **Drug name stem** \-dotin ### Open Targets indications (4) - **Condition identifier** EFO\_0003060 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0021040 **Highest recorded phase** 1 ## Chemical properties **Calculated partition coefficient (XLogP)** 4.5 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Heavy atoms** 94 **Molecular formula** C68H107N11O15 **Monoisotopic mass** 1317.79481175 **Natural product** No ## Related records ### Trials (10) - [A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)](https://trialight.com/data/trial/a-clinical-study-of-zilovertamab-vedotin-mk-2140-plus-134b8f98-3329-4e9d-af03-b73bfdbc1295.md) - A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001) - A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006) - A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007) - A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003) - A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002) - [A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)](https://trialight.com/data/trial/a-study-to-evaluate-zilovertamab-vedotin-mk-2140-combination-47c43a74-d190-4960-aac9-afe2cea567bf.md) - A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004) - A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A) - Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01) ### In development for (4) - [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 3 - [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 1 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2 - [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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