> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/vasopressin-592303bd-1d7e-43c7-af55-8c1dcb6024f0
> Record changed: 2026-10-13

# Vasopressin

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

First approval year

2014

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

## Development status

**First approval year**

2014

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

**Drug name**

Vasopressin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

**Molecular weight**

1,084.25

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

**Structure (SMILES)**

N=C(N)NCCC\[C@H\](NC(=O)\[C@@H\]1CCCN1C(=O)\[C@@H\]1CSSC\[C@H\](N)C(=O)N\[C@@H\](Cc2ccc(O)cc2)C(=O)N\[C@@H\](Cc2ccccc2)C(=O)N\[C@@H\](CCC(N)=O)C(=O)N\[C@@H\](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

### Brand names (10)

- beta hypophamine
- Beta-hypophamine
- leiormone
- Leiormone
- vasophysin
- Vasophysin
- vasopressin component of hbn 1
- Vasopressin component of hbn-1
- vasostrict
- Vasostrict

### Other names (46)

- 8 l argininevasopressin
- 8-L-ARGININEVASOPRESSIN
- arginin vasopressin
- arginine vasopressin
- Arginine vasopressin
- Arginine Vasopressin
- ARGININE VASOPRESSIN \[MI\]
- arginine vasopressin mi
- argipressin
- Argipressin
- argipressin \[INN\]
- ARGIPRESSIN \[MART.\]
- Argipressin \[WHO-DD\]
- argipressin inn
- argipressin mart
- argipressin or lypressin
- Argipressin or lypressin
- argipressin who dd
- cys tyr phe gln asn cys pro arg gly nh2 1 6 disulphide
- CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 (1-6 DISULPHIDE)
- hbn 1 component vasopressin
- HBN-1 COMPONENT VASOPRESSIN
- inyectable de vasopresina
- Inyectable de vasopresina
- solute injectable de vasopressine

And 21 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 113-79-1

**ChEMBL ID**

CHEMBL373742

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

**InChIKey**

KBZOIRJILGZLEJ-LGYYRGKSSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL373742)

**PubChem compound IDs**

- 644077

**RxNorm IDs (RxCUI)**

- 11149

**FDA ingredient codes (UNII)**

- Y4907O6MFD

## Regulatory information

### United States

**Applicant**

AM REGENT

**Approval date**

3 Aug 2020

**Application number**

NDA212593

### Other regulatory facts

**Patents**

16

**Designations**

0

**Earliest recorded loss of exclusivity**

27 Sept 2044

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

vasopressin

**Type**

Peptide

**Drug name stem**

\-pressin

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action (7)

- **Mechanism**  
Vasopressin receptor agonist

**Action type**  
Agonist

**Target**  
Vasopressin receptor

**Protein identifier**  
P30518
- **Mechanism**  
Vasopressin receptor agonist

**Action type**  
Agonist

**Target**  
Vasopressin receptor

**Protein identifier**  
P37288
- **Mechanism**  
Vasopressin receptor agonist

**Action type**  
Agonist

**Target**  
Vasopressin receptor

**Protein identifier**  
P47901
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
V2 receptor

**Gene symbol**  
AVPR2

**Protein identifier**  
P30518

**Affinity units**  
pKi

**Primary target**  
Yes
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
V1A receptor

**Gene symbol**  
AVPR1A

**Protein identifier**  
P37288

**Affinity units**  
pKi

**Primary target**  
Yes
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
V1B receptor

**Gene symbol**  
AVPR1B

**Protein identifier**  
P47901

**Affinity units**  
pKi

**Primary target**  
Yes
- **Action**  
Partial agonist

**Action type**  
PARTIAL\_AGONIST

**Target**  
OT receptor

**Gene symbol**  
OXTR

**Protein identifier**  
P30559

**Affinity units**  
pKi

### Open Targets mechanisms

- **Mechanism**  
Vasopressin receptor agonist

**Action type**  
Agonist

**Target**  
Vasopressin receptor

### DrugCentral mechanisms (3)

- **Action type**  
Agonist

**Gene symbol**  
AVPR2

**Protein identifier**  
P30518

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Agonist

**Gene symbol**  
AVPR1A

**Protein identifier**  
P37288

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Agonist

**Gene symbol**  
AVPR1B

**Protein identifier**  
P47901

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (20)

- **Condition**  
Child Development Disorders, Pervasive

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003756

**Subject identifier**  
D002659
- **Condition**  
Autistic Disorder

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003758

**Subject identifier**  
D001321
- **Condition**  
Heart Diseases

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003777

**Subject identifier**  
D006331
- **Condition**  
Pain

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D010146
- **Condition**  
Death, Sudden, Cardiac

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004278

**Subject identifier**  
D016757
- **Condition**  
Acute Lung Injury

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004610

**Subject identifier**  
D055371
- **Condition**  
Hernias, Diaphragmatic, Congenital

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005207

**Subject identifier**  
D065630
- **Condition**  
Hypotension

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0005251

**Subject identifier**  
D007022
- **Condition**  
Shock, Septic

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0006834

**Subject identifier**  
D012772
- **Condition**  
Heart Arrest

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009492

**Subject identifier**  
D006323
- **Condition**  
Pleural Effusion

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0009637

**Subject identifier**  
D010996
- **Condition**  
Abortion, Spontaneous

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001255

**Subject identifier**  
D000022
- **Condition**  
Shock

**Highest recorded phase**  
3

**Condition identifier**  
HP:0031273

**Subject identifier**  
D012769
- **Condition**  
Sepsis

**Highest recorded phase**  
4

**Condition identifier**  
HP:0100806

**Subject identifier**  
D018805
- **Condition**  
Leiomyoma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001572

**Subject identifier**  
D007889
- **Condition**  
Depressive Disorder, Major

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002009

**Subject identifier**  
D003865
- **Condition**  
Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0002254

**Subject identifier**  
D013577
- **Condition**  
Myoma

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0003061

**Subject identifier**  
D009214
- **Condition**  
Diabetes Insipidus

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0004782

**Subject identifier**  
D003919
- **Condition**  
Hypertension, Pulmonary

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005149

**Subject identifier**  
D006976

### Open Targets indications (45)

- **Condition identifier**  
EFO\_0000714

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003756
- **Condition identifier**  
EFO\_0003758
- **Condition identifier**  
EFO\_0003777

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0004278

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004610

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005251
- **Condition identifier**  
EFO\_0006834

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009492

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009516
- **Condition identifier**  
EFO\_0009909

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001255

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001373

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000083
- **Condition identifier**  
HP\_0000103
- **Condition identifier**  
HP\_0000103

**Highest recorded phase**  
4
- **Condition identifier**  
HP\_0000131
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0001662

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0002637
- **Condition identifier**  
HP\_0012531

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0012531

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0031273

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0100806
- **Condition identifier**  
HP\_0100806

**Highest recorded phase**  
4

And 20 more, listed on the interactive page.

### Reported adverse events (81)

- **Event**  
acidosis

**Reports**  
4

**Reporting signal score**

8.28738
- **Event**  
acute kidney injury

**Reports**  
25

**Reporting signal score**

26.3757
- **Event**  
anuria

**Reports**  
9

**Reporting signal score**

24.2239
- **Event**  
arteriospasm coronary

**Reports**  
8

**Reporting signal score**

24.7265
- **Event**  
bradycardia

**Reports**  
12

**Reporting signal score**

11.4899
- **Event**  
carcinoid crisis

**Reports**  
3

**Reporting signal score**

15.4847
- **Event**  
cardiac arrest

**Reports**  
25

**Reporting signal score**

60.793
- **Event**  
cardiac failure

**Reports**  
9

**Reporting signal score**

8.68559
- **Event**  
cardiogenic shock

**Reports**  
36

**Reporting signal score**

138.927
- **Event**  
cardiotoxicity

**Reports**  
8

**Reporting signal score**

20.3341
- **Event**  
circulatory collapse

**Reports**  
8

**Reporting signal score**

16.3925
- **Event**  
coma scale abnormal

**Reports**  
5

**Reporting signal score**

13.8637
- **Event**  
compartment syndrome

**Reports**  
6

**Reporting signal score**

19.5261
- **Event**  
condition aggravated

**Reports**  
18

**Reporting signal score**

8.13806
- **Event**  
crush syndrome

**Reports**  
2

**Reporting signal score**

10.5384
- **Event**  
cyanosis

**Reports**  
10

**Reporting signal score**

22.3314
- **Event**  
diabetes insipidus

**Reports**  
21

**Reporting signal score**

98.4405
- **Event**  
disseminated intravascular coagulation

**Reports**  
6

**Reporting signal score**

12.4837
- **Event**  
distributive shock

**Reports**  
8

**Reporting signal score**

35.5648
- **Event**  
drug-device interaction

**Reports**  
2

**Reporting signal score**

11.329
- **Event**  
dry gangrene

**Reports**  
8

**Reporting signal score**

41.8072
- **Event**  
electrocardiogram qrs complex prolonged

**Reports**  
5

**Reporting signal score**

12.486
- **Event**  
electrocardiogram st segment elevation

**Reports**  
4

**Reporting signal score**

9.91488
- **Event**  
extremity necrosis

**Reports**  
8

**Reporting signal score**

32.8348
- **Event**  
gangrene

**Reports**  
7

**Reporting signal score**

22.6253

And 56 more, listed on the interactive page.

### Trial references (29)

- NCT00269685  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00269685)
- NCT00481572  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00481572)
- NCT01718613  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01718613)
- NCT00358579  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00358579)
- NCT00628550  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00628550)
- NCT00729794  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00729794)
- NCT05139849  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05139849)
- NCT05738148  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05738148)
- NCT00411879  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00411879)
- NCT03640949  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03640949)
- NCT00420407  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00420407)
- NCT01505231  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01505231)
- NCT01611935  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01611935)
- NCT03483753  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03483753)
- NCT00624650  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00624650)
- NCT01370096  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01370096)
- NCT01606384  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01606384)
- NCT01861015  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01861015)
- NCT01962870  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01962870)
- NCT02975999  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02975999)
- NCT03088345  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03088345)
- NCT03204786  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03204786)
- NCT03446456  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03446456)
- NCT03636451  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03636451)
- NCT03736681  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03736681)

And 4 more, listed on the interactive page.

## Dosing

**Dose**

0.01-0.1 units/minute

**Route**

Intravenous

**How often**

Every 10 to 15 minutes until target; then taper

### Conditions of use (2)

- Discard unused solution after 18 hours at room temperature or 24 hours refrigerated
- Titrate to lowest effective dose

## Chemical properties

**Calculated partition coefficient (XLogP)**

\-4.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

75

**Molecular formula**

C46H65N15O12S2

**Monoisotopic mass**

1083.43785492

**Natural product**

No

## National Drug Codes

- 0338-9640
- 0338-9647
- 0517-1020
- 0517-1030
- 0548-9701
- 25021-474
- 55150-370
- 63323-930
- 65219-039
- 68083-520
- 68083-663
- 72572-860
- 84549-370
- 51662-1682
- 51662-1688
- 70121-1642
- 71872-7306
- 81298-8552
- 81298-8554

## Evidence counts

**Recorded assays**

471

**Active assays**

118

### Active assay types (2)

- Confirmatory
- Other

## Pharmacologic actions

- Hemostatics  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D006490.html)
- Vasoconstrictor Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014662.html)
- Antidiuretic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D050034.html)

## Related records

### Trials (90)

- Angiotensin II vs. Vasopressin in Septic Shock
- Argipressin's Influence on Blood Loss During Hepatic Resection
- Arterial Pressure and Stress-Dose Steroids in Cardiac Arrest.
- AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
- Brain Imaging Study of Adults With Autism Spectrum Disorders
- CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
- Cardiac Output Response to Vasopressin Infusion In Abdominal Surgery Patients Under Mechanical Ventilation
- Combined Vasopressin, Methylprednisolone, and Epinephrine for Inhospital Cardiac Arrest
- Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
- Comparison of Concentration of Vasopressin During Robot-assisted Laparoscopic Myomectomy
- Comparison of the Effects of Cervical Vasopressin Versus no Premedication on Blood Loss During Vaginal Hysterectomy: A Randomized, Placebo Controlled Trial
- Comparison of Vasopressin and Other Pressors in Septic Shock
- Continuous Infusion of Terlipressin in Septic Shock
- Decision Support for Intraoperative Low Blood Pressure
- Differential Effects of Vasopressin and Oxytocin on Attention Control
- Discontinuation Order of Vasopressors in Septic Shock
- Early Use of Vasopressin in Post-Fontan Management
- Early Versus Late Adjunctive Vasopressin in Septic Shock
- Effect of Vasopressin Versus Norepinephrine on Post-operative Mean Pulmonary Arterial Pressure Following Pulmonary Endarterectomy Surgery,
- Effect of Vasopressin vs Norepinephrine on Pulmonary Oxygenation and Lung Mechanics in Patients With Hypertension Therapy During One-lung Ventilation : Preliminary Study

### Approved for (1)

- [Diabetes insipidus](https://trialight.com/data/condition/diabetes-insipidus-eb0e3300-ebb1-5892-a012-f19eda2b45b3.md)

### In development for (14)

- [Acute lung injury](https://trialight.com/data/condition/acute-lung-injury-fb11c447-d7f6-5c24-8fb9-764bbaaabced.md) Phase 2
- Autism Phase 2
- Autism spectrum disorder Phase 2
- Benign muscle neoplasm Phase 3
- [Cardiac arrest](https://trialight.com/data/condition/cardiac-arrest-aa5c0aed-2b70-5846-9872-ccd2a7b23670.md) Phase 3
- Congenital heart disease Phase 2
- Heart disorder Phase 3
- Hypotensive disorder Early phase 1
- [Leiomyoma](https://trialight.com/data/condition/leiomyoma-f84b9cb4-e902-5ed0-bb93-4d36211170f3.md) Phase 2
- [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) Phase 2
- [Pulmonary hypertension](https://trialight.com/data/condition/pulmonary-hypertension-1e275435-e811-5e99-a8d1-abef649a72f4.md) Phase 2
- Sudden cardiac arrest Phase 2
- Syndromic disease Phase 3
- Toxic shock syndrome Phase 3

### Other linked conditions (3)

- Enuresis
- [Schizophrenia](https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a.md)
- Uterine corpus leiomyoma

### Targets (3)

- [AVPR1A](https://trialight.com/data/target/avpr1a-9e0d16e5-7d9c-530e-8937-823c361e897a.md) Vasopressin receptor agonist
- [AVPR1B](https://trialight.com/data/target/avpr1b-23475468-807c-5646-8f15-f2cc20d96829.md) Vasopressin receptor agonist
- [AVPR2](https://trialight.com/data/target/avpr2-9e511853-9fb7-5fbc-83e8-ec6d25930de7.md) Vasopressin receptor agonist

---

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