> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/varicella-zoster-virus-envelope-glycoprotein-e-ff6f0103-e6e7-4f17-9aed-0ca05c8633ef > Record changed: 2026-10-13 # Varicella zoster virus envelope glycoprotein E Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) Drug type Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) First approval year 2018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) ## Development status **First approval year** 2018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) ## Names and chemistry **Drug type** Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) **Drug name** Varicella zoster virus envelope glycoprotein E Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) ### Brand names (2) - shingrix - Shingrix ### Other names (20) - gsk 1437173a - GSK 1437173A - Gsk-1437173a - Herpes Zoster vaccine (GSK1437173A) - herpes zoster vaccine gsk1437173a - Herpes zoster vaccine gsk1437173a - Herpes zoster vaccine GSK1437173A - Herpes Zoster vaccine GSK1437173A - Herpes Zoster Vaccine GSK1437173A - Recombinant Herpes Zoster Vaccine (Shingrix) - Recombinant varicella zoster virus (vzv) glycoprotein e - recombinant varicella zoster virus vzv glycoprotein e - Recombinant zoster vaccine adjuvanted (SHINGRIX) - shingrix - Shingrix - SHINGRIX - Shingrix® - SHINGRIX® - varicella zoster virus envelope glycoprotein e - Varicella zoster virus envelope glycoprotein e ## Identifiers **ChEMBL ID** CHEMBL4297975 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297975) ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** vir- ### Mechanisms of action - **Mechanism** Envelope glycoprotein E vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Envelope glycoprotein E **Protein identifier** Q9J3M8 ### Open Targets mechanisms - **Mechanism** Envelope glycoprotein E vaccine antigen **Action type** VACCINE ANTIGEN **Target** Envelope glycoprotein E ### Investigated indications (3) - **Condition** Respiratory Tract Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0000684 **Subject identifier** D012140 - **Condition** Vaccination **Highest recorded phase** 4 **Condition identifier** EFO:0004292 **Subject identifier** D014611 - **Condition** Herpes Zoster **Highest recorded phase** 4 **Condition identifier** EFO:0006510 **Subject identifier** D006562 ### Open Targets indications (6) - **Condition identifier** EFO\_0000684 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001068 **Highest recorded phase** 3 - **Condition identifier** EFO\_0006509 **Highest recorded phase** 1 - **Condition identifier** EFO\_0006510 - **Condition identifier** MONDO\_0005136 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005609 **Highest recorded phase** 4 ### Reported adverse events (42) - **Event** affective disorder **Reports** 2 **Reporting signal score** 6.50143 - **Event** aortitis **Reports** 2 **Reporting signal score** 10.9066 - **Event** arthralgia **Reports** 7 **Reporting signal score** 6.39882 - **Event** borrelia infection **Reports** 2 **Reporting signal score** 12.0225 - **Event** bowel movement irregularity **Reports** 2 **Reporting signal score** 7.56817 - **Event** diverticulitis **Reports** 3 **Reporting signal score** 6.97396 - **Event** encephalitis **Reports** 2 **Reporting signal score** 6.41887 - **Event** feeling hot **Reports** 3 **Reporting signal score** 6.01757 - **Event** herpes zoster **Reports** 11 **Reporting signal score** 31.365 - **Event** herpes zoster cutaneous disseminated **Reports** 4 **Reporting signal score** 28.3095 - **Event** herpes zoster reactivation **Reports** 2 **Reporting signal score** 14.0446 - **Event** immunodeficiency **Reports** 3 **Reporting signal score** 11.098 - **Event** inflammation **Reports** 4 **Reporting signal score** 9.07666 - **Event** joint swelling **Reports** 4 **Reporting signal score** 5.65811 - **Event** macular degeneration **Reports** 2 **Reporting signal score** 6.47833 - **Event** micturition urgency **Reports** 3 **Reporting signal score** 10.3408 - **Event** myalgia **Reports** 5 **Reporting signal score** 6.00497 - **Event** ophthalmic herpes zoster **Reports** 2 **Reporting signal score** 8.97016 - **Event** oropharyngeal pain **Reports** 4 **Reporting signal score** 7.06276 - **Event** osteoarthritis **Reports** 3 **Reporting signal score** 6.23658 - **Event** pain **Reports** 14 **Reporting signal score** 19.1861 - **Event** pain of skin **Reports** 4 **Reporting signal score** 14.8685 - **Event** peripheral swelling **Reports** 6 **Reporting signal score** 9.56977 - **Event** photophobia **Reports** 3 **Reporting signal score** 8.89227 - **Event** pneumonia **Reports** 9 **Reporting signal score** 11.5476 And 17 more, listed on the interactive page. ### Trial references (29) - NCT00434577 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00434577) - NCT00802464 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00802464) - NCT01165177 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01165177) - NCT01165203 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01165203) - NCT01165229 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01165229) - NCT01610414 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01610414) - NCT01751165 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01751165) - NCT01777321 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01777321) - NCT02058589 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02058589) - NCT02690207 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02690207) - NCT02723773 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02723773) - NCT02735915 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02735915) - NCT04091451 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04091451) - NCT04169009 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04169009) - NCT05245838 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05245838) - NCT05304351 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05304351) - NCT05554068 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05554068) - NCT05580458 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05580458) - NCT05596526 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05596526) - NCT05701800 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05701800) - NCT05703607 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05703607) - NCT05718037 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05718037) - NCT05769049 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05769049) - NCT05991427 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05991427) - NCT06137755 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06137755) And 4 more, listed on the interactive page. ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (72) - A Long-term Follow-up Study (ZOE-LTFU) of Two Studies 110390 (ZOSTER-006) and 113077 (ZOSTER-022) to Assess the Efficacy, Safety, and Immunogenicity Persistence of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine and Assessment of 1 or 2 Additional Doses in Two Subgroups of Older Adults - A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IV Clinical Trial to Evaluate the Immunogenicity and Safety of a Live Attenuated Herpes Zoster Vaccine in Adults Aged 40 Years and Older - [A Phase 2 Study to Describe the Safety, Reactogenicity, and Immunogenicity of Herpes Zoster IN001 mRNA Vaccine (IN001) in Healthy Participants](https://trialight.com/data/trial/a-phase-2-study-to-describe-the-safety-reactogenicity-and-d8d17c11-83f4-4153-a35c-7f126cddd614.md) - [A Phase 2 Study to Evaluate JCXH-105, an srRNA-based Herpes Zoster Vaccine](https://trialight.com/data/trial/a-phase-2-study-to-evaluate-jcxh-105-an-srrna-based-herpes-3a027b54-d9ad-4a35-86f2-8f5f84f5a6f2.md) - A Phase I Clinical Trial of Recombinant Herpes Zoster Vaccine (CHO Cell) - A Phase Ⅲ Clinical Study to Evaluate Protective Efficacy and Safety of a Recombinant Herpes Zoster Vaccine - A Safety and Immunogenicity Trial of the Recombinant Zoster Vaccine （CHO Cell）, LYB004 in Adults Aged 50 to 70 Years - A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants - [A Study to Describe the Safety, Reactogenicity, and Immunogenicity of Herpes Zoster IN001 mRNA Vaccine (IN001) in Healthy Participants](https://trialight.com/data/trial/a-study-to-describe-the-safety-reactogenicity-and-986f04e3-a481-4314-9a15-a454b83d2c79.md) - A Study to Evaluate the Safety and Immunogenicity of ChAdOx1-VZV in Healthy Adults Aged 50-65 Years - [A Study to Evaluate the Safety of Recombinant Herpes Zoster Vaccine for Healthy Individuals](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-of-recombinant-herpes-zoster-fc877502-f051-4555-95c4-eddaa705efa7.md) - [A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of Age](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-reactogenicity-and-660d6578-7ec1-4370-8e33-b1e8bc6c2935.md) - [A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Recombinant Herpes Zoster Vaccine](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-tolerability-and-86b74299-817b-44fd-b4b8-d5586124617a.md) - [A Study to Learn About a Modified RNA Vaccine Against Shingles in Healthy Adults](https://trialight.com/data/trial/a-study-to-learn-about-a-modified-rna-vaccine-against-3e26c431-af2d-4342-bc23-54831513cb43.md) - A Study to Test GlaxoSmithKline's (GSK) Herpes Zoster (HZ) Subunit Vaccine's Long-term Immune Response in Previously Vaccinated Kidney Transplant Adults and Then to Test if 2 Additional Doses of the Vaccine Are Safe and Able to Generate an Immune Response - Age Differences in Influenza and Herpes Zoster Vaccine Responses (INFLUENZA-SHINGRIX) - Clinical Trial to Evaluate EuHZV in Healthy Adults Aged 50 to 69 Years - Consistency, Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults ≥ 50 Years of Age - Cross-vaccination Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies. - Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine GSK1437173A in Adults With a Prior Episode of Herpes Zoster ### Approved for (1) - [Herpes zoster](https://trialight.com/data/condition/herpes-zoster-b5c04cf4-ae28-5154-8254-f4f1fde4c3c9.md) ### In development for (3) - [Malaria](https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853.md) Phase 3 - Respiratory system disorder Phase 2 - [Varicella zoster infection](https://trialight.com/data/condition/varicella-zoster-infection-8bfd714d-2964-5abf-b7ab-66dea5fe7146.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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