> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/vamikibart-2182fd06-d79c-4c0d-b628-e778467f24f6 > Record changed: 2026-10-13 # Vamikibart Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315020) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315020) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315020) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315020) **Drug name** Vamikibart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315020) ### Other names (27) - ebi 031 - Ebi-031 - EBI-031 - ebi031 - EBI031 - Immunoglobulin G2 \[311-alanine\], anti-(human interleukin 6) (human monoclonal RG6179 γ2-chain), disulfide with human monoclonal RG6179 κ-chain, dimer - immunoglobulin g2 311 alanine anti human interleukin 6 human monoclonal rg6179 γ2 chain disulfide with human monoclonal rg6179 κ chain dimer - immunoglobulin g2 kappa anti homo sapiens il6 interleukin 6 humanized and chimeric monoclonal antibody gamma2 heavy chain humanized 1 448 vh homo sapiens ighv1 69 11 86 7 ighd ighj5 02 90 9 l123 t 117 cdr imgt 8 8 15 26 33 51 58 97 111 1 122 homo sapiens ighg2 01 g2m ch2 v45 1 g2v8 ch2 a93 ch1 123 220 hinge 1 12 221 232 ch2 v45 1 283 h93 a 311 233 341 ch3 342 446 chs 447 448 123 448 136 218 disulfide with kappa light chain chimeric 1 218 v kappa musmus homsap mus musculus igkv3 2 01 79 8 igkj2 03 90 9 s120 q 104 homo sapiens igkv4 1 01 79 2 igkj2 01 100 cdr imgt 10 3 9 27 36 54 56 93 101 1 111 homo sapiens igkc 01 km3 a45 1 157 v101 195 112 218 dimer 224 224 225 225 228 228 231 231 tetrakisdisulfide produced in chinese hamster ovary cho cells cell line cho k1m glycoform alfa - immunoglobulin G2-kappa, anti-\[Homo sapiens IL6 (interleukin 6)\], humanized and chimeric monoclonal antibody; gamma2 heavy chain humanized (1-448) \[VH ( Homo sapiens IGHV1-69\*11 (86.7%) -(IGHD) -IGHJ5\*02 (90.9%) L123>T (117), CDR-IMGT \[8.8.15\] (26-33.51-58.97-111)) (1-122) - Homo sapiens IGHG2\*01, G2m.. CH2 V45.1, G2v8 CH2 A93 (CH1 (123-220), hinge 1-12 (221-232), CH2 V45.1 (283), H93>A (311) (233-341), CH3 (342-446), CHS (447-448)) (123-448)\], (136-218')-disulfide with kappa light chain chimeric (1'-218') \[V-KAPPA Musmus/Homsap (Mus musculus IGKV3- 2\*01 (79.8%) -IGKJ2\*03 (90.9%) S120>Q (104)/Homo sapiens IGKV4-1\*01 (79.2%) -IGKJ2\*01 (100%), CDR-IMGT \[10.3.9\] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC\*01, Km3 A45.1 (157), V101 (195) (112'-218')\]; dimer (224-224'':225-225'':228-228'':231-231'')-tetrakisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1M, glycoform alfa - recombinant humanised igg2 kappa anti interleukin 6 monoclonal antibody ro7200220 - RECOMBINANT HUMANISED IGG2 KAPPA ANTI-INTERLEUKIN 6 MONOCLONAL ANTIBODY RO7200220 - rg 6179 - RG-6179 - rg6179 - RG6179 - ro 7200220 - RO-7200220 - ro7200220 - RO7200220 - vamikibart - Vamikibart - vamikibart \[INN\] - VAMIKIBART \[USAN\] - Vamikibart \[WHO-DD\] - vamikibart inn And 2 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 2744320-12-3 **ChEMBL ID** CHEMBL5315020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5315020) **FDA ingredient codes (UNII)** - KP04MH1JTT ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications (2) - **Condition** Macular Edema **Highest recorded phase** 3 **Condition identifier** MONDO:0003005 **Subject identifier** D008269 - **Condition** Inflammation **Highest recorded phase** 2 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (4) - **Condition identifier** EFO\_0009321 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0003005 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004728 **Highest recorded phase** 2 - **Condition identifier** MP\_0001845 ### Trial references (2) - NCT05642312 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05642312) - NCT05642325 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05642325) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGSSVKVSCKASGYVLPNYLIEWVRQAPGQGLEWMGVTTPGGGTINYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARSRWDPLYYYALEYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVAQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-92' $ 23'''-92''' $ 136-218' $ 136''-218''' $ 138'-198' $ 138'''-198''' $ 149-205 $ 149''-205'' $ 224-224'' $ 225-225'' $ 228-228'' $ 231-231'' $ 262-322 $ 262''-322'' $ 368-426 $ 368''-426'' - **Component** Light chain **Type** Protein **Sequence** DIVMTQSPDSLAVSLGERATINCRASESVDNYGIPFMNWYQQKPGQPPKLLIYAASNRGSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSEEVPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 298 $ 298'' ## Related records ### Trials (9) - A Safety, Efficacy and Pharmacokinetic Study of Siltuximab (CNTO 328) in Participants With Solid Tumors - A Study to Investigate RO7200220 as Monotherapy and in Combination With Ranibizumab in Participants With Diabetic and Uveitic Macular Edema - A Study to Investigate Vamikibart (RO7200220) in Combination With Ranibizumab in Diabetic Macular Edema - [A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema](https://trialight.com/data/trial/a-study-to-investigate-vamikibart-ro7200220-in-diabetic-602d496f-b703-440d-85f5-bc3029a02482.md) - A Study to Investigate Vamikibart in Participants With Uveitic Macular Edema - Anti-IL6 and Corticosteroid Monotherapy vs Combination in COVID-19 - Interleukin 6-guided Antibiotic Prescriptions in AECOPD Inpatients - Safety Study of Intravitreal EBI-031 Given as a Single or Repeat Injection to Subjects With Diabetic Macular Edema - Vamikibart in Participants With Uveitic Macular Edema ### In development for (2) - [Diabetic macular edema](https://trialight.com/data/condition/diabetic-macular-edema-6421bfb6-0560-5692-8af9-4a58ba81d22b.md) Phase 2 - [Macular retinal edema](https://trialight.com/data/condition/macular-retinal-edema-893472dc-a81c-5efb-b457-9a4c0884e5e5.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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