> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/upadacitinib-tartrate-d4be96e3-53b4-4c52-b14a-5df155bd386e
> Record changed: 2026-10-13

# Upadacitinib tartrate

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

**Drug name**

Upadacitinib tartrate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

**Molecular weight**

602.52

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

**Structure (SMILES)**

CC\[C@@H\]1CN(C(=O)NCC(F)(F)F)C\[C@@H\]1c1cnc2cnc3\[nH\]ccc3n12.O.O.O.O.O=C(O)C(O)C(O)C(=O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

### Other names (8)

- abt 494 tartrate tetrahydrate
- ABT-494 TARTRATE TETRAHYDRATE
- upadacitinib tartrate
- Upadacitinib tartrate
- UPADACITINIB TARTRATE \[USAN\]
- upadacitinib tartrate tetrahydrate
- UPADACITINIB TARTRATE TETRAHYDRATE
- upadacitinib tartrate usan

## Identifiers

**CAS registry numbers**

- 1607431-21-9

**ChEMBL ID**

CHEMBL3707269

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

**InChIKey**

LATZVDXOTDYECD-UFTFXDLESA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707269)

**FDA ingredient codes (UNII)**

- 7KCW9IQM02

### PubChem compound IDs (2)

- 122197532
- 127263217

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-tinib

### Open Targets mechanisms (4)

- **Mechanism**  
Tyrosine-protein kinase JAK1 inhibitor

**Action type**  
Inhibitor

**Target**  
Tyrosine-protein kinase JAK1
- **Mechanism**  
Tyrosine-protein kinase JAK2 inhibitor

**Action type**  
Inhibitor

**Target**  
Tyrosine-protein kinase JAK2
- **Mechanism**  
Tyrosine-protein kinase JAK3 inhibitor

**Action type**  
Inhibitor

**Target**  
Tyrosine-protein kinase JAK3
- **Mechanism**  
Tyrosine-protein kinase TYK2 inhibitor

**Action type**  
Inhibitor

**Target**  
Non-receptor tyrosine-protein kinase TYK2

### Open Targets indications (29)

- **Condition identifier**  
EFO\_0009856

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0002094

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0002098

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0002360

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0010447

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0012378

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0100543

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005011

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005083
- **Condition identifier**  
MONDO\_0005101

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005265
- **Condition identifier**  
MONDO\_0005306

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005340

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005361

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006559

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007191

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007915

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008383

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0008538

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0008558

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008661

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0010030

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011429

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0011849

**Highest recorded phase**  
4

And 4 more, listed on the interactive page.

### Open Targets warnings (2)

- **Warning**  
Black Box Warning

**Effect**  
carcinogenicity

**Country**  
United States
- **Warning**  
Black Box Warning

**Effect**  
vascular toxicity

**Country**  
United States

### Reported adverse events (15)

- **Event**  
antibiotic therapy

**Reports**  
8

**Reporting signal score**

25.0786
- **Event**  
covid-19

**Reports**  
110

**Reporting signal score**

213.213
- **Event**  
herpes zoster

**Reports**  
66

**Reporting signal score**

83.0762
- **Event**  
illness

**Reports**  
50

**Reporting signal score**

107.373
- **Event**  
infected lymphocele

**Reports**  
5

**Reporting signal score**

23.2141
- **Event**  
infection

**Reports**  
55

**Reporting signal score**

32.1648
- **Event**  
localised infection

**Reports**  
24

**Reporting signal score**

32.8098
- **Event**  
lumbosacral plexopathy

**Reports**  
6

**Reporting signal score**

33.3652
- **Event**  
oral lichen planus

**Reports**  
7

**Reporting signal score**

24.1549
- **Event**  
perineal rash

**Reports**  
6

**Reporting signal score**

32.1383
- **Event**  
rheumatoid arthritis

**Reports**  
58

**Reporting signal score**

42.0142
- **Event**  
sars-cov-2 test positive

**Reports**  
13

**Reporting signal score**

26.5293
- **Event**  
sinusitis

**Reports**  
49

**Reporting signal score**

37.1492
- **Event**  
therapy interrupted

**Reports**  
204

**Reporting signal score**

699.51
- **Event**  
urinary tract infection

**Reports**  
92

**Reporting signal score**

72.6318

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

2

**Polar surface area**

78.32

**Calculated partition coefficient (ALogP)**

2.91

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

41

**Molecular formula**

C21H33F3N6O11

**Monoisotopic mass**

602.21594038

**Natural product**

No

## Related records

### Trials (114)

- A 24-Week Real-World Study of Upadacitinib in Moderate-to-Severe Hidradenitis Suppurativa
- A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
- A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants
- A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs
- A Pragmatic Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial Spondyloarthritis
- A Prospective Cohort Study Evaluating the Efficacy and Safety of Guselkumab (GUS) With JAK Inhibitors in Patients With Difficult-To-Treat Inflammatory Bowel Disease (IBD)
- A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)
- A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
- A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD)
- A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone
- A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug
- A Study Evaluating the Safety and Efficacy of Upadacitinib in Adults With Active Ankylosing Spondylitis
- A Study in Rheumatoid Arthritis Patients Who Have Completed a Preceding Study With ABBV-105 Given Alone or in Combination With Upadacitinib
- A Study Investigating the Efficacy and Safety of Upadacitinib (ABT-494) Given With Methotrexate (MTX) in Adults With Rheumatoid Arthritis Who Have Had an Inadequate Response to MTX Alone
- A Study of Oral Upadacitinib Tablet Compared to Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa to Assess Change in Disease Symptoms
- A Study of Oral Upadacitinib Tablets to Assess Change in Disease State in Participants Aged 12-75 Years With Moderate to Severe Atopic Dermatitis in Brazil
- A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy
- A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis
- A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies
- A Study of the Safety of Oral Elsubrutinib Capsules and Oral Upadacitinib Tablets Given Alone or in Combination (ABBV-599) for Adult Participants With Moderately to Severely Active Systemic Lupus Erythematosus to Assess Change in Disease State

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