> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ulixacaltamide-a60cecca-ea24-4594-8087-1ef1617fa4dc
> Record changed: 2026-10-13

# Ulixacaltamide

Highest phase reached

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

**Drug name**

Ulixacaltamide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

**Molecular weight**

383.9

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

**Structure (SMILES)**

CC(C)(C)NC(=O)CN1CCC(CNC(=O)c2cc(F)cc(Cl)c2)CC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

### Other names (18)

- np 169944
- NP-169944
- np169944
- NP169944
- prax 944
- PRAX-944
- prax944
- PRAX944
- ulixacaltamide
- Ulixacaltamide
- ulixacaltamide \[INN\]
- ULIXACALTAMIDE \[USAN\]
- ulixacaltamide inn
- ulixacaltamide usan
- z 944
- Z-944
- z944
- Z944

## Identifiers

**CAS registry numbers**

- 1199236-64-0

**ChEMBL ID**

CHEMBL3934636

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

**InChIKey**

JOCLITFYIMJMNK-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3934636)

**PubChem compound IDs**

- 44540045

**FDA ingredient codes (UNII)**

- QT2PJH89C3

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

ulixacaltamide

**Type**

Synthetic organic

### Mechanisms of action (3)

- **Action**  
Pore blocker

**Action type**  
PORE\_BLOCKER

**Target**  
Cav3.1

**Gene symbol**  
CACNA1G

**Protein identifier**  
O43497

**Median affinity**

7.3

**Affinity units**  
pIC50
- **Action**  
Pore blocker

**Action type**  
PORE\_BLOCKER

**Target**  
Cav3.2

**Gene symbol**  
CACNA1H

**Protein identifier**  
O95180

**Median affinity**

6.8

**Affinity units**  
pIC50
- **Action**  
Pore blocker

**Action type**  
PORE\_BLOCKER

**Target**  
Cav3.3

**Gene symbol**  
CACNA1I

**Protein identifier**  
Q9P0X4

**Median affinity**  
7

**Affinity units**  
pIC50

### Investigated indications

- **Condition**  
Essential Tremor

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003108

**Subject identifier**  
D020329

### Open Targets indications (2)

- **Condition identifier**  
EFO\_0003108

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0003233

**Highest recorded phase**  
3

## Chemical properties

**Hydrogen bond acceptors**

3

**Hydrogen bond donors**

2

**Polar surface area**

61.44

**Calculated partition coefficient (ALogP)**

2.84

**Calculated partition coefficient (XLogP)**

3

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

26

**Molecular formula**

C19H27ClFN3O2

**Monoisotopic mass**

383.1775830

**Natural product**

No

## Evidence counts

**Recorded assays**

13

**Active assays**

12

### Active assay types (2)

- Confirmatory
- Other

## Pharmacologic actions

- Calcium Channel Blockers  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D002121.html)

## Related records

### Trials (3)

- A Clinical Trial of 2 Doses of PRAX-944 in Participants With Essential Tremor
- A Clinical Trial of PRAX-944 in Participants With Essential Tremor
- [Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)](https://trialight.com/data/trial/essential-3-decentralized-phase-3-study-evaluating-the-981c757f-3a6c-4bdd-9669-b423ee6943a3.md)

### In development for (1)

- [Essential tremor](https://trialight.com/data/condition/essential-tremor-09253a73-0c42-5900-b88c-9a316fd21b51.md) Phase 1

---

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