> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ubrogepant-8361e028-0d26-4b8f-97d3-849085bb72c3
> Record changed: 2026-10-13

# Ubrogepant

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

First approval year

2019

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

## Development status

**First approval year**

2019

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

**Drug name**

Ubrogepant

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

**Molecular weight**

549.55

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

**Structure (SMILES)**

C\[C@@H\]1\[C@H\](c2ccccc2)C\[C@H\](NC(=O)c2cnc3c(c2)C\[C@@\]2(C3)C(=O)Nc3ncccc32)C(=O)N1CC(F)(F)F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

### Brand names (2)

- ubrelvy
- Ubrelvy

### Other names (17)

- mk 1602
- MK-1602
- ubrogepant
- Ubrogepant
- ubrogepant \[INN\]
- UBROGEPANT \[MI\]
- UBROGEPANT \[ORANGE BOOK\]
- UBROGEPANT \[USAN\]
- Ubrogepant \[WHO-DD\]
- Ubrogepant 100 mg
- ubrogepant anhydrous
- Ubrogepant anhydrous
- ubrogepant inn
- ubrogepant mi
- ubrogepant orange book
- ubrogepant usan
- ubrogepant who dd

## Identifiers

**ATC classification codes**

- N02CD04

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

**CAS registry numbers**

- 1374248-77-7

**ChEMBL ID**

CHEMBL2364638

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

**InChIKey**

DDOOFTLHJSMHLN-ZQHRPCGSSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2364638)

**PubChem compound IDs**

- 68748835

**RxNorm IDs (RxCUI)**

- 2268216

**FDA ingredient codes (UNII)**

- AD0O8X2QJR

## Regulatory information

### United States

**Applicant**

ABBVIE

**Approval date**

23 Dec 2019

**Application number**

NDA211765

### Other regulatory facts

**Patents**

16

**Designations**

0

**Earliest recorded loss of exclusivity**

22 Dec 2041

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

ubrogepant

**Type**

Synthetic organic

**Drug name stem**

\-gepant

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral

### Mechanisms of action (3)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
CGRP receptor

**Gene symbol**  
RAMP1

**Protein identifier**  
O60894

**Median affinity**

10.8

**Affinity units**  
pKB
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
CGRP receptor

**Gene symbol**  
CALCRL

**Protein identifier**  
Q16602

**Median affinity**

10.8

**Affinity units**  
pKB
- **Mechanism**  
Calcitonin gene-related peptide type 1 receptor antagonist

**Action type**  
Antagonist

**Target**  
Calcitonin gene-related peptide type 1 receptor

**Protein identifier**  
Q16602

### Open Targets mechanisms

- **Mechanism**  
Calcitonin gene-related peptide type 1 receptor antagonist

**Action type**  
Antagonist

**Target**  
Calcitonin gene-related peptide type 1 receptor

### DrugCentral mechanisms

- **Action type**  
Antagonist

**Gene symbol**  
CALCRL

**Protein identifier**  
Q16602

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications

- **Condition**  
Migraine Disorders

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0005277

**Subject identifier**  
D008881

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0008008
- **Condition identifier**  
MONDO\_0005277
- **Condition identifier**  
MONDO\_0005277

**Highest recorded phase**  
4

### Reported adverse events (3)

- **Event**  
facial paralysis

**Reports**  
3

**Reporting signal score**

9.88568
- **Event**  
mast cell degranulation present

**Reports**  
1

**Reporting signal score**

10.0887
- **Event**  
migraine

**Reports**  
8

**Reporting signal score**

18.7323

### Trial references (13)

- NCT01613248  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01613248)
- NCT01657370  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01657370)
- NCT02828020  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02828020)
- NCT02867709  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02867709)
- NCT02873221  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02873221)
- NCT04179474  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04179474)
- NCT04492020  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04492020)
- NCT04818515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04818515)
- NCT05125302  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05125302)
- NCT05127954  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05127954)
- NCT05264129  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05264129)
- NCT05503082  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05503082)
- NCT06417775  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06417775)

## Dosing

**Dose**

50-100mg

**Route**

Oral

**How often**

As needed

### Conditions of use (2)

- Maximum 200mg per 24 hours
- Second dose at least 2 hours after initial dose

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

2

**Polar surface area**

104.29

**Calculated partition coefficient (ALogP)**

3.53

**Calculated partition coefficient (XLogP)**

3.1

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

4

**Heavy atoms**

40

**Molecular formula**

C29H26F3N5O3

**Monoisotopic mass**

549.19877419

**Natural product**

No

## National Drug Codes

- 0023-6498
- 0023-6501

## Evidence counts

**Recorded assays**

10

**Active assays**

6

### Active assay types

- Confirmatory

## Related records

### Trials (19)

- A Dose-Finding Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-006)
- A Pharmacokinetic Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-007)
- A Trial Investigating Lu AG09222 With Ubrogepant in Participants With Migraine
- An Extension Study to Evaluate the Long-Term Safety and Tolerability of Ubrogepant in the Treatment of Migraine
- Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine
- Efficacy, Safety, and Tolerability Study of Oral Ubrogepant in the Acute Treatment of Migraine
- Evaluation of the Efficacy of Almotriptan and Ubrogepant for the Acute Treatment of Migraine
- Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin
- [Long-term Extension Study to Assess Safety and Tolerability of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Pediatric Participants (Ages 6-17)](https://trialight.com/data/trial/long-term-extension-study-to-assess-safety-and-tolerability-203d5688-df1b-4ff5-8e5c-3d6505bfbb48.md)
- Migraine Medication Effects on Urinary Symptoms
- Safety, Tolerability and Drug- Drug Interaction Study of Ubrogepant With Erenumab or Galcanezumab in Participants With Migraine
- Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine
- Study to Assess Adverse Events and Compare How Oral Ubrogepant and Oral Atogepant Moves Through the Body of Healthy Female Adult Volunteers
- [Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)](https://trialight.com/data/trial/study-to-assess-adverse-events-and-disease-activity-of-oral-d2a8b6c8-5563-4c44-bd3e-909640b94445.md)
- Study To Assess Adverse Events and Drug to Drug Interaction of Oral Tablet Atogepant and Ubrogepant in Adult Participants With a History of Migraine
- Study to Assess Adverse Events When Ubrogepant Tablets in Combination With Atogepant Tablets Are Used to Treat Adult Participants With Migraine
- Study to Assess How Different Oral Formulations of Ubrogepant Move Through the Body in Healthy Adult Participants
- Study to Evaluate Oral Ubrogepant in the Acute Treatment of Migraine During the Prodrome in Adult Participants
- Ubrogepant treatmeNt in mIgraine Patients Utilizing mOnoclonal aNtibodies

### Approved for (1)

- [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md)

### Targets (1)

- [CALCRL](https://trialight.com/data/target/calcrl-ab682234-2bfa-51bd-a9eb-e0d3e9a4ee16.md) Calcitonin gene-related peptide type 1 receptor antagonist

---

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