> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ubamatamab-8b11cb87-3e84-42e6-9739-f86e1ad58449
> Record changed: 2026-10-13

# Ubamatamab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594595)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594595)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594595)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594595)

**Drug name**

Ubamatamab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594595)

### Other names (19)

- anti muc16 cd3 bite antibody regn4018
- ANTI-MUC16/CD3 BITE ANTIBODY REGN4018
- bispecific t cell engager antibody regn4018
- BISPECIFIC T-CELL ENGAGER ANTIBODY REGN4018
- muc16xcd3 bispecific t cell engager regn4018
- MUC16XCD3 BISPECIFIC T-CELL ENGAGER REGN4018
- regn 4018
- REGN-4018
- regn4018
- Regn4018
- REGN4018
- ubamatamab
- Ubamatamab
- ubamatamab \[INN\]
- UBAMATAMAB \[USAN\]
- Ubamatamab \[WHO-DD\]
- ubamatamab inn
- ubamatamab usan
- ubamatamab who dd

## Identifiers

**CAS registry numbers**

- 2305629-50-7

**ChEMBL ID**

CHEMBL4594595

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594595)

**FDA ingredient codes (UNII)**

- 6BUL1G4D60

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Investigated indications (3)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003893

**Subject identifier**  
D010051
- **Condition**  
Fallopian Tube Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002158

**Subject identifier**  
D005185

### Open Targets indications (10)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0003893
- **Condition identifier**  
MONDO\_0002715

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006260

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008170
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0017387

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0021068

### Trial references

- NCT03564340  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03564340)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (6)

- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-293'''' $ Asn-300
- **Component**  
Heavy chain B

**Type**  
Protein

**Sequence**  
QVQLVESGGGLVKPGGSLRLSCAASGFTFSNYYMSWVRQAPGKGLEWISYISGRGSTIFYADSVKGRITISRDNAKNSLFLQMNSLRAEDTAVYFCVKDRGGYSPYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCRASQSISTYLNWYQQKPGKAPKLLIYTASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 135'-195' $ 135'''-195''' $ 131''-215''' $ 138-215' $ 144''-200'' $ 151-207 $ 223''-230 $ 226'-233 $ 257''-317'' $ 264-324 $ 363''-421'' $ 370-428
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-293'' $ Asn-300
- **Component**  
Sequence: REGN5458 Heavy Chain X'' (anti-CD3)

**Type**  
Protein

**Sequence**  
EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYSMHWVRQAPGKGLEWVSGISWNSGSKGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKYGSGYGKFYHYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNRFTQKSLSLSPGK

## Related records

### Trials (7)

- A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab
- [A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)](https://trialight.com/data/trial/a-study-to-investigate-ubamatamab-with-and-without-82d42eac-e19e-4600-8624-6e0997ca5c0b.md)
- Compassionate Use of Ubamatamab
- [Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer](https://trialight.com/data/trial/investigation-of-ubamatamab-combination-therapy-in-adult-571a016d-ba62-43ca-b0b5-d60047ff3fb0.md)
- Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies
- Safety and Efficacy of Ubamatamab With First-line Chemotherapy in Ovarian Cancer
- Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

### In development for (3)

- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 1
- Neoplasm Phase 1
- [Ovarian neoplasm](https://trialight.com/data/condition/ovarian-neoplasm-1e9924ea-041c-5daa-b6c4-a97ec4fabeda.md) Phase 1

### Other linked conditions (1)

- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md)

---

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