> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tulisokibart-277938cc-2675-4600-86a8-7e344fc0dcab > Record changed: 2026-10-13 # Tulisokibart Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095370) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095370) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095370) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095370) **Drug name** Tulisokibart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095370) ### Other names (20) - Immunoglobulin G1 \[234-alanine,235-alanine,329-alanine\], anti-(human tumor necrosis factor superfamily protein TNFSF15) (human monoclonal PRA023 γ1-chain), disulfide with human monoclonal PRA023 κ-chain, dimer - immunoglobulin g1 234 alanine 235 alanine 329 alanine anti human tumor necrosis factor superfamily protein tnfsf15 human monoclonal pra023 γ1 chain disulfide with human monoclonal pra023 κ chain dimer - immunoglobulin g1 kappa anti homo sapienstnfsf15 tumor necrosis factor tnf superfamily member 15 tl1a vascular endothelial cell growth inhibitor 192 a vegi192a membrane and soluble humanized monoclonal antibody - immunoglobulin g1 kappa anti homo sapienstnfsf15 tumor necrosis factor tnf superfamily member 15 tl1a vascular endothelial cell growth inhibitor 192 a vegi192a membrane and soluble humanized monoclonal antibody gamma1 heavy chain humanized 1 446 vh homo sapiens ighv1 46 02 80 6 ighd ighj6 01 100 cdr imgt 8 8 9 26 33 51 58 97 105 1 116 homo sapiens ighg1 01 g1m17 1 g1v14 ch2 a1 3 a1 2 g1v4 ch2 a114 ch1 k120 213 117 214 hinge 1 15 215 229 ch2l1 3 a 233 l1 2 a 234 p114 a 328 230 339 ch3 d12 355 l14 357 340 444 chs 445 446 117 446 219 213 disulfide with kappa light chain humanized 1 213 v kappa homo sapiens igkv3d 11 02 85 6 igkj4 01 90 9 cdr imgt 5 3 9 27 31 49 51 88 96 1 106 homo sapiens igkc 01 100 km3 a45 1 152 v101 190 107 213 dimer 225 225 228 228 bisdisulfide produced in chinese hamster ovary cho cells cell line cho dg44 glycoform alfa - immunoglobulin G1-kappa, anti-\[Homo sapiensTNFSF15 (tumor necrosis factor (TNF) superfamily member 15, TL1A, vascular endothelial cell growth inhibitor 192-A, VEGI192A), membrane and soluble\], humanized monoclonal antibody; gamma1 heavy chain humanized (1-446) \[VH (Homo sapiens IGHV1-46\*02 (80.6%) -(IGHD) -IGHJ6\*01 (100%), CDR-IMGT \[8.8.9\](26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1\*01, G1m17,1, G1v14 CH2 A1.3, A1.2, G1v4 CH2 A114 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2L1.3>A (233), L1.2>A (234), P114>A(328) (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)\], (219-213')- disulfide with kappa light chain humanized (1'-213') \[V-KAPPA (Homo sapiens IGKV3D-11\*02 (85.6%) -IGKJ4\*01 (90.9%), CDR-IMGT \[5.3.9\] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (152), V101 (190) (107'- 213')\]; dimer (225-225'': 228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa - immunoglobulin G1-kappa, anti-\[Homo sapiensTNFSF15(tumor necrosis factor (TNF) superfamily member 15, TL1A, vascular endothelial cell growth inhibitor 192-A, VEGI192A), membrane and soluble\], humanized monoclonal antibody - iv tulisokibart - IV Tulisokibart - pra 023 - PRA-023 - pra023 - PRA023 - tulisokibart - Tulisokibart - tulisokibart \[INN\] - TULISOKIBART \[USAN\] - Tulisokibart \[WHO-DD\] - tulisokibart inn - tulisokibart usan - tulisokibart who dd ## Identifiers **CAS registry numbers** - 2648504-55-4 **ChEMBL ID** CHEMBL5095370 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095370) **FDA ingredient codes (UNII)** - ON09TCS5H3 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications (3) - **Condition** Crohn Disease **Highest recorded phase** 3 **Condition identifier** EFO:0000384 **Subject identifier** D003424 - **Condition** Colitis, Ulcerative **Highest recorded phase** 3 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Lung Diseases, Interstitial **Highest recorded phase** 1 **Condition identifier** HP:0006515 **Subject identifier** D017563 ### Open Targets indications (9) - **Condition identifier** EFO\_0000384 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000710 **Highest recorded phase** 2 - **Condition identifier** HP\_0006515 - **Condition identifier** MONDO\_0005011 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006559 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0011849 **Highest recorded phase** 2 ### Trial references (4) - NCT04996797 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04996797) - NCT06052059 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06052059) - NCT05013905 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05013905) - NCT06430801 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06430801) ## Chemical properties **Prodrug** No **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGASVKVSCKASGFDIQDTYMHWVKQRPGQGLEWMGRIDPASGHTKYDPKFQVRVTITRDTSTSTVYLELSSLRSEDTAVYYCARSGGLPDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNARTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPTEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-87' $ 23'''-87''' $ 133'-193' $ 133'''-193''' $ 143-199 $ 143''-199'' $ 219-213' $ 219''-213''' $ 225-225'' $ 228-228'' $ 260-320 $ 260''-320'' $ 366-424 $ 366''-424'' - **Component** Light chain **Type** Protein **Sequence** ETVLTQSPGTLSLSPGERATLSCRASSSVSYMYWYQQKPGQAPRPLTYATSNLASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQWEGNPRTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 296 $ 296' ## Related records ### Trials (15) - [A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)](https://trialight.com/data/trial/a-clinical-study-of-tulisokibart-mk-7240-to-treat-9ececae7-ad3e-4a4a-8e7a-849ea5224536.md) - A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014) - A Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Moderately to Severely Active Ulcerative Colitis (MK-7240-005) - A Phase 2a Safety and Efficacy Open-Label Study of Tulisokibart (MK-7240/PRA023) in Participants With Moderately to Severely Active Crohn's Disease (MK-7240-006) - [A Study of MK-7240 in Healthy Participants (MK-7240-009)](https://trialight.com/data/trial/a-study-of-mk-7240-in-healthy-participants-mk-7240-009-fa076ef8-5834-4f40-b125-4d6141ea0705.md) - A Study of PRA023 in Healthy Volunteers - [A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)](https://trialight.com/data/trial/a-study-to-evaluate-efficacy-and-safety-of-tulisokibart-mk-e29cbb8a-5968-40ea-a6ef-4c1160697b70.md) - [A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-tulisokibart-129c646c-86c6-4d0c-a19b-a78024e85a16.md) - Bioavailability of SC Formulation and Japanese Ethnobridging Study for PRA023 - [Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)](https://trialight.com/data/trial/extension-study-of-long-term-safety-and-efficacy-of-78094ef3-6484-4098-b699-f2b441b2f001.md) - Pharmacokinetic (PK) Characterization of Subcutaneous Tulisokibart (MK-7240-010) - Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007) - Single Dose Study of Tulisokibart (MK-7240) in Healthy Chinese Participants (MK-7240-002) - Study to Evaluate Tulisokibart for Hidradenitis Suppurativa (MK-7240-012) - Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015) ### In development for (4) - [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md) Phase 3 - [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Phase 2 - [Interstitial lung disease](https://trialight.com/data/condition/interstitial-lung-disease-745f5770-ba0b-517d-b691-5b9731a03266.md) Phase 1 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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