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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/treprostinil-phosphate-4e3cf856-6450-401c-bce8-dbc2e155bb28 > Record changed: 2026-11-04 # Treprostinil phosphate Highest phase reached Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) ## Development status **Listing at source** Listed **Highest phase reached** Phase 1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) **Drug name** Treprostinil phosphate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) **Molecular weight** 550.48 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) **Structure (SMILES)** CCCCC\[C@@H\](CC\[C@@H\]1\[C@H\]2Cc3cccc(OCC(=O)O)c3C\[C@H\]2C\[C@H\]1OP(=O)(O)O)OP(=O)(O)O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) ### Other names (8) - treprostinil bisphosphate - Treprostinil bisphosphate - treprostinil phosphate - Treprostinil phosphate - TREPROSTINIL PHOSPHATE \[USAN\] - treprostinil phosphate usan - ut 86 - UT-86 ## Identifiers **CAS registry numbers** - 830354-49-9 **ChEMBL ID** CHEMBL5314603 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) **InChIKey** IERCXWVEMYXPMR-KSSXRGRSSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314603) **PubChem compound IDs** - 156104640 **FDA ingredient codes (UNII)** - 99S2PY5BN2 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-prost- ### Investigated indications - **Condition** Pulmonary Arterial Hypertension **Highest recorded phase** 1 **Condition identifier** EFO:0001361 **Subject identifier** D000081029 ### Open Targets indications (2) - **Condition identifier** EFO\_0001361 - **Condition identifier** MONDO\_0015924 ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 5 **Polar surface area** 180.05 **Calculated partition coefficient (ALogP)** 3.82 **Calculated partition coefficient (XLogP)** 2.3 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 14 **Heavy atoms** 36 **Molecular formula** C23H36O11P2 **Monoisotopic mass** 550.17328596 **Natural product** No ## Related records ### Trials (25) - A Pharmacokinetic Substudy of the TDE-PH-304 Protocol - A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) - Addition of UT-15C SR to Pulmonary Arterial Hypertension Patients Currently Receiving Tyvaso® - An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE - Efficacy and Safety of Oral UT-15C Tablets to Treat Pulmonary Arterial Hypertension - [Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease](https://trialight.com/data/trial/extension-study-of-inhaled-treprostinil-in-subjects-with-305b4c1e-4bc0-4640-bf75-8035f9c0be1d.md) - Hypotonic Treprostinil Subcutaneous Infusion for Control of Treprostinil Related Site Pain - Inhaled Treprostinil Expanded Access Program in Pulmonary Hypertension Associated With Interstitial Lung Disease - Inhaled Treprostinil for PAH: Open-label Extension - Inhaled Treprostinil in Participants With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD) - Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension - Investigational Trial to Evaluate Safety and Tolerability of Treprostinil in Children Diagnosed With PAH - Multinational Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis - Observation Study With Implantable Medication Pump for Intravenous Treprostinil Therapy in Patients With Pulmonary Arterial Hypertension - Pulmonary Rehab in Chronic Obstructive Pulmonary Disease (COPD): Response to Tyvaso - Remodulin® to Oral Treprostinil Transition - Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE - Safety and Tolerability of Inhaled Treprostinil in Adult PH Due to COPD - Safety of Transition From Selexipag to Remodulin® Then Oral Treprostinil in Symptomatic Adult PAH - Safety, Tolerability, Pharmacokinetics and Efficacy of Two Different Rates of Subcutanous Remodulin® Dose Titration in Pulmonary Arterial Hypertension ### In development for (1) - Pulmonary arterial hypertension Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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