> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/travoprost-9549e46b-63f9-4c5f-afa4-916bf1dd436a
> Record changed: 2026-11-04

# Travoprost

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

First approval year

2001

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

## Development status

**First approval year**

2001

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

**Drug name**

Travoprost

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

**Molecular weight**

500.55

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

**Structure (SMILES)**

CC(C)OC(=O)CCC/C=C\\C\[C@@H\]1\[C@@H\](/C=C/\[C@@H\](O)COc2cccc(C(F)(F)F)c2)\[C@H\](O)C\[C@@H\]1O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

### Brand names (12)

- idose tr
- Idose tr
- izba
- Izba
- travatan
- Travatan
- travatan z
- Travatan z
- travoprost
- Travoprost
- travoprost component of duotrav
- Travoprost component of duotrav

### Other names (73)

- (1R-(1.ALPHA.(Z),2.BETA.(1E,3R\*),3.ALPHA.,5.ALPHA.))-7-(3,5-DIHYDROXY-2-(3-HYDROXY-4-(3-(TRIFLUOROMETHYL)PHENOXY)-1-BUTENYL)CYCLOPENTYL)-5-HEPTENOIC ACID, 1-METHYLETHYL ESTER
- 1r 1 alpha z 2 beta 1e 3r 3 alpha 5 alpha 7 3 5 dihydroxy 2 3 hydroxy 4 3 trifluoromethyl phenoxy 1 butenyl cyclopentyl 5 heptenoic acid 1 methylethyl ester
- al 6221
- AL-6221
- DuoTrav (travoprost-timolol ophthalmic drops)
- duotrav component travoprost
- DUOTRAV COMPONENT TRAVOPROST
- duotrav travoprost timolol ophthalmic drops
- idose tr
- iDose TR
- Idose tr
- iDose TR (travoprost intracameral implant) 75 µg
- iDose TR (travoprost intracameral implant) 75 μg in conjunction
- iDose TR (Travoprost intracameral Implant) 75mcg
- idose tr travoprost intracameral implant 75 µg
- idose tr travoprost intracameral implant 75 μg in conjunction
- idose tr travoprost intracameral implant 75mcg
- latanoprost bimatoprost travoprost
- nsc 760366
- NSC-760366
- otx tp
- Otx-tp
- OTX-TP
- topical travoprost
- Topical travoprost

And 48 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- S01EE04

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

**CAS registry numbers**

- 157283-68-6

**ChEMBL ID**

CHEMBL1200799

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

**InChIKey**

MKPLKVHSHYCHOC-AHTXBMBWSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200799)

**PubChem compound IDs**

- 5282226

**RxNorm IDs (RxCUI)**

- 283809

**FDA ingredient codes (UNII)**

- WJ68R08KX9

## Regulatory information

### United States

**Applicant**

SANDOZ

**Approval date**

21 Sept 2006

**Application number**

NDA021994

### European Union

**Status**

Authorised

**Status date**

27 Nov 2001

**Authorisation date**

27 Nov 2001

**Approved indications**

Decrease of elevated intraocular pressure in adult patients with ocular hypertension or open-angle glaucoma (see section 5.1). Decrease of elevated intraocular pressure in paediatric patients aged 2 months to < 18 years with ocular hypertension or paediatric glaucoma (see section 5.1).

**Product number**

EMEA/H/C/000390

**Authorisation holder**

Novartis Europharm Limited

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

No

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Glaucoma, Open-Angle
- Ocular Hypertension

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/travatan)

### Other regulatory facts

**Patents**

11

**Designations**

1

**Earliest recorded loss of exclusivity**

14 Feb 2031

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Approval status

**United States (FDA)**

Approved

**European Union (EMA)**

Authorised

## Pharmacology

### Drug classification

**Pharmacology name**

travoprost

**Type**

Synthetic organic

**Drug name stem**

\-prost

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- topical

### Mechanisms of action

- **Mechanism**  
Prostanoid FP receptor agonist

**Action type**  
Agonist

**Target**  
Prostaglandin F2-alpha receptor

**Protein identifier**  
P43088

### Open Targets mechanisms

- **Mechanism**  
Prostanoid FP receptor agonist

**Action type**  
Agonist

**Target**  
Prostaglandin F2-alpha receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
PTGFR

**Protein identifier**  
P43088

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (4)

- **Condition**  
Glaucoma, Open-Angle

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0004190

**Subject identifier**  
D005902
- **Condition**  
Exfoliation Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004235

**Subject identifier**  
D017889
- **Condition**  
Ocular Hypertension

**Highest recorded phase**  
4

**Condition identifier**  
EFO:1001069

**Subject identifier**  
D009798
- **Condition**  
Glaucoma

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0005041

**Subject identifier**  
D005901

### Open Targets indications (13)

- **Condition identifier**  
EFO\_0004190
- **Condition identifier**  
EFO\_0004235

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001060
- **Condition identifier**  
EFO\_1001069
- **Condition identifier**  
HP\_0000737
- **Condition identifier**  
MONDO\_0001868

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001966

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005041
- **Condition identifier**  
MONDO\_0005041

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005338

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0006875

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0008327
- **Condition identifier**  
MONDO\_0019783

### Reported adverse events (61)

- **Event**  
abnormal sensation in eye

**Reports**  
7

**Reporting signal score**

15.9262
- **Event**  
asthenia

**Reports**  
7

**Reporting signal score**

14.3899
- **Event**  
blepharal pigmentation

**Reports**  
4

**Reporting signal score**

16.4762
- **Event**  
blepharitis

**Reports**  
11

**Reporting signal score**

27.8035
- **Event**  
blindness

**Reports**  
31

**Reporting signal score**

44.003
- **Event**  
blindness unilateral

**Reports**  
12

**Reporting signal score**

18.9656
- **Event**  
blood immunoglobulin e increased

**Reports**  
8

**Reporting signal score**

19.4267
- **Event**  
choroidal detachment

**Reports**  
6

**Reporting signal score**

18.5258
- **Event**  
choroidal effusion

**Reports**  
7

**Reporting signal score**

21.0157
- **Event**  
conjunctival hyperaemia

**Reports**  
11

**Reporting signal score**

24.1213
- **Event**  
conjunctival oedema

**Reports**  
6

**Reporting signal score**

16.3521
- **Event**  
conjunctivitis allergic

**Reports**  
6

**Reporting signal score**

16.7507
- **Event**  
corneal disorder

**Reports**  
7

**Reporting signal score**

16.6124
- **Event**  
corneal oedema

**Reports**  
9

**Reporting signal score**

20.2777
- **Event**  
cystoid macular oedema

**Reports**  
10

**Reporting signal score**

25.7938
- **Event**  
dark circles under eyes

**Reports**  
7

**Reporting signal score**

24.7617
- **Event**  
diarrhoea

**Reports**  
11

**Reporting signal score**

28.6982
- **Event**  
dry eye

**Reports**  
37

**Reporting signal score**

64.9464
- **Event**  
erythema of eyelid

**Reports**  
12

**Reporting signal score**

30.1926
- **Event**  
eye allergy

**Reports**  
15

**Reporting signal score**

64.4427
- **Event**  
eye disorder

**Reports**  
22

**Reporting signal score**

32.4215
- **Event**  
eye inflammation

**Reports**  
16

**Reporting signal score**

35.3418
- **Event**  
eye irritation

**Reports**  
141

**Reporting signal score**

439.515
- **Event**  
eye pain

**Reports**  
74

**Reporting signal score**

168.233
- **Event**  
eye pruritus

**Reports**  
44

**Reporting signal score**

100.807

And 36 more, listed on the interactive page.

### Trial references (44)

- NCT00051142  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051142)
- NCT00051155  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051155)
- NCT00051168  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051168)
- NCT00051181  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00051181)
- NCT00288951  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00288951)
- NCT00293761  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00293761)
- NCT00293787  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00293787)
- NCT00293800  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00293800)
- NCT00311389  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00311389)
- NCT00333125  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00333125)
- NCT00767494  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00767494)
- NCT01452009  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01452009)
- NCT01453855  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01453855)
- NCT01464424  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01464424)
- NCT01652664  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01652664)
- NCT01655758  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01655758)
- NCT00308945  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00308945)
- NCT00331240  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00331240)
- NCT01443988  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01443988)
- NCT01444040  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01444040)
- NCT02754596  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02754596)
- NCT02873806  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02873806)
- NCT03966560  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03966560)
- NCT04615403  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04615403)
- NCT06066645  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06066645)

And 19 more, listed on the interactive page.

## Dosing

**Dose**

One drop

**Route**

Topical

**How often**

Once daily

### Conditions of use (2)

- Administer in the evening
- Do not administer more than once daily

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

3

**Polar surface area**

96.22

**Calculated partition coefficient (ALogP)**

4.43

**Calculated partition coefficient (XLogP)**

4.1

**Prodrug**

Yes

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

12

**Heavy atoms**

35

**Molecular formula**

C26H35F3O6

**Monoisotopic mass**

500.23857332

**Natural product**

No

## National Drug Codes

- 0078-0946
- 0378-9651
- 25021-002
- 25357-100
- 42571-130
- 46708-625
- 51407-731
- 62332-510
- 62332-625
- 66758-095
- 68083-601
- 68083-602
- 68462-943
- 70069-586
- 70069-587
- 60505-0593
- 71335-2738
- 71335-2888
- 72162-2432

## Evidence counts

**Recorded assays**

45

**Active assays**

5

### Active assay types

- Confirmatory

## Pharmacologic actions

- Antihypertensive Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000959.html)

## Related records

### Trials (102)

- 1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT
- 24-hour Control of Intraocular Pressure (IOP) in Ocular Hypertension
- 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination
- 24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost
- 6-Week Proof-of-Concept Study of Travoprost/Brinzolamide Ophthalmic Suspension in Subjects With Open-Angle Glaucoma or Ocular Hypertension
- A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma
- A 6-Week Safety and Efficacy Study of Travatan Compared to Xalcom in Subjects With Open-Angle Glaucoma(OAG) or Ocular Hypertension(OHT)
- A Long-term Safety Study of Once-daily Travatan
- A Multicenter Study of the Pigmentation in the Trabecular Meshwork After Two Years of Treatment With TRAVATAN 0.004% Ophthalmic Solution
- A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension
- A Phase IV Study of Travoprost + Brinzolamide to Treat Glaucoma or Ocular Hypertension
- A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma
- A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)
- A Single Dose Comfort Comparison of Travatan Z in One Eye Versus Xalatan in the Opposite Eye in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
- A Study Assessing PG286 Ophthalmic Solution, 0.5% Compared to Its Individual Components for 28 Days
- A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
- A Study to Evaluate the Efficacy and Safety of OTX-TIC (Travoprost) Intracameral Implant for Patients With Open-angle Glaucoma (OAG) or Ocular Hypertension (OHT)
- Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma
- Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan
- An Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension

### Approved for (3)

- [Glaucoma](https://trialight.com/data/condition/glaucoma-7a3c05c0-9871-55db-af74-962761181784.md)
- [Ocular hypertension](https://trialight.com/data/condition/ocular-hypertension-754666dc-b494-5a18-a3ee-6a2d941c65dd.md)
- [Open-angle glaucoma](https://trialight.com/data/condition/open-angle-glaucoma-fb887921-4122-599b-b8a0-928b40ddc7a2.md)

### In development for (3)

- Chronic closed-angle glaucoma Phase 3
- Exfoliation syndrome Phase 3
- Primary angle-closure glaucoma Phase 3

### Other linked conditions (1)

- Neovascular glaucoma

### Targets (1)

- [PTGFR](https://trialight.com/data/target/ptgfr-83fefc82-9ff1-5dc0-bef4-0577cb8c0adb.md) Prostanoid FP receptor agonist

---

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