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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/trastuzumab-rezetecan-ff208505-42a4-4c94-aaa2-807da0cdd343 > Record changed: 2026-10-13 # Trastuzumab rezetecan Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314712) Drug type Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314712) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314712) ## Names and chemistry **Drug type** Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314712) **Drug name** Trastuzumab rezetecan Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314712) ### Other names (23) - famitinib shr a1811 - immunoglobulin g1 anti human epidermal growth factor receptor her2 human mus musculus monoclonal shr 1805 γ1 chain complex with human mus musculus monoclonal shr 1805 κ chain dimer thioether with n 6 3 mercapto 2 5 dioxo 1 pyrrolidinyl 1 oxohexyl glycylglycyl l phenylalanyl n 1r 1 cyclopropyl 2 1s 9s 9 ethyl 5 fluoro 2 3 9 10 13 15 hexahydro 9 hydroxy 4 methyl 10 13 dioxo 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino 2 oxoethoxy methyl glycinamide - immunoglobulin g1 kappa anti homo sapiens erbb2 epidermal growth factor receptor 2 receptor tyrosine protein kinase erbb 2 egfr2 her2 her 2 p185c erbb2 neu cd340 humanized monoclonal antibody conjugated via a cleavable linker with a camptothecin derivative - immunoglobulin G1-kappa, anti-\[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)\], humanized monoclonal antibody, conjugated via a cleavable linker with a camptothecin derivative - Immunoglobulin G1, anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal SHR-1805 γ1-chain), complex with human-Mus musculus monoclonal SHR-1805 κ-chain, dimer, thioether with N-\[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl\]glycylglycyl-L-phenylalanyl-N-\[\[(1R)-1-cyclopropyl-2-\[\[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo\[de\]pyrano\[3′,4′:6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino\]-2-oxoethoxy\]methyl\]glycinamide - shr a1811 - Shr a1811 - SHR- A1811 - SHR-A1811 - SHR-A1811 for injection - SHR-A1811 for Injection - SHR-A1811 Injection - SHR-A1811 Subcutaneous Injection - trastuzumab rezetecan - Trastuzumab rezetecan - Trastuzumab Rezetecan - Trastuzumab Rezetecan (SHR-A1811) - trastuzumab rezetecan \[INN\] - Trastuzumab rezetecan \[WHO-DD\] - Trastuzumab Rezetecan for Injection - Trastuzumab Rezetecan for Injection (SHR-A1811) - trastuzumab rezetecan inn - trastuzumab rezetecan who dd ## Identifiers **CAS registry numbers** - 2647845-11-0 **ChEMBL ID** CHEMBL5314712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314712) **FDA ingredient codes (UNII)** - 1000BJC8CR ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Drug name stem** \-mab; -mab; -tecan ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (21) - **Condition identifier** EFO\_0000616 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000521 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002158 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002974 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0003060 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0003219 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005036 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005140 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005494 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008177 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0015686 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0018364 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0040679 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 300 $ 300 '' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428'' ## Related records ### Trials (111) - A Clinical Study of SHR-A1811 Combined With Chemotherapy for Platinum Sensitive Recurrent Ovarian Cancer - A Clinical Study of SHR-A1811 in the Treatment of HER2-positive Locally Advanced or Metastatic Biliary Tract Cancer - A Clinical Study of SHR-A1811(sc) Subcutaneous Injection in Patients With Solid Tumor - A Clinical Trial of SHR-A1811 in the Treatment of Triple-negative Breast Cancer - A Multicenter, Single-Arm, Prospective Phase II Clinical Study of Trastuzumab Rezetecan Combined With Radiotherapy in Patients With HER2-Mutated Oligoprogressive Advanced Non-Small Cell Lung Cancer - A Phase 1 Study of SHR-A1811 in Patients With Selected HER2 Expressing Tumors - A Phase Ⅰb/Ⅱ Clinical Study of SHR-A1811 Combined With Other Therapies in Patients With HER2 Low Advanced or Metastatic Breast Cancer. - [A Phase Ib/II Study of SHR-A1811 Injection in Breast Cancer](https://trialight.com/data/trial/a-phase-ib-ii-study-of-shr-a1811-injection-in-breast-cancer-1311d1bf-f240-48c4-8818-ea0d54fbcd1e.md) - A Phase II Study of Advanced Salivary Gland Carcinoma Based on Molecular Typing - A Phase II Study of SHR-A1811 Combined With Radiotherapy in HER2-positive and HER2-low Breast Cancer Brain Metastases - A Phase II Trial of SHR-A1811 in HER2-Expressing Recurrent/Metastatic Cervical Cancer - A Phase III Study of SHR-A1811 in Combination With Chemotherapy and Adebrelimab in Previously Untreated Patients With Gastric or Gastroesophageal Junction Adenocarcinoma - A Phase III Study of SHR-A1811 Injection With or Without Pertuzumab in HER2-Positive Recurrent or Metastatic Breast Cancer - [A Phase III, Active-Controlled Study of SHR-A1811 Versus Trastuzumab Emtansine (T-DM1) in HER2-Positive Primary Breast Cancer Participants With Residual Invasive Disease Following Neoadjuvant Therapy](https://trialight.com/data/trial/a-phase-iii-active-controlled-study-of-shr-a1811-versus-2163526e-b8fe-46db-b528-e17ea9f82c63.md) - A Prospective Phase II Clinical Trial Evaluating the Efficacy and Safety of Adebrelimab in Combination With Trastuzumab Rezetecan for Patients With Stage III Unresectable HER2-Positive NSCLC - A Randomized, Open-Label, Controlled, Multicenter Phase III Clinical Study of SHR-A1811 in Combination With Chemotherapy and Bevacizumab Versus Standard Therapy as First-Line Treatment for Advanced Colorectal Cancer - A Real-World Study of Trastuzumab Rezetecan in HER2+ Solid Tumors - A Study of HRS-4508 in Combination With Other Anti-tumor Therapy for Solid Tumor - A Study of SHR-4610 Injection in Patients With Advanced Solid Tumors - A Study of SHR-A1811 and Fulvestrant, With or Without HS-10352, in Locally Advanced or Metastatic Breast Cancer Patients ### In development for (2) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3 - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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