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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/trastuzumab-pamirtecan-3237c753-c395-444b-b7ad-7c343e73b346 > Record changed: 2026-10-13 # Trastuzumab pamirtecan Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068309) Drug type Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068309) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068309) ## Names and chemistry **Drug type** Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068309) **Drug name** Trastuzumab pamirtecan Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068309) ### Other names (18) - bnt 323 - BNT-323 - db 1303 - DB 1303 \[WHO-DD\] - db 1303 who dd - DB-1303 - h gamma1 heavy chain humanized 1 449 vh homo sapiens ighv3 66 01 81 6 ighd ighj4 01 100 cdr imgt 8 8 13 26 33 51 58 97 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 234 343 ch3 e12 359 m14 361 344 448 chs k2 del 449 121 449 223 214 disulfide with l kappa light chain humanized 1 214 v kappa homo sapiens igkv1 39 01 86 3 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 v101 c kappa a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in a cell line from chinese hamster ovary cho cells derived from the cell line cho k1 glycoform alfa substituted at the sulfur atoms of l cysteinyl residues 223 229 232 214 223 229 232 and 214 with 3rs 1 7s 7 benzyl 1 1r 3r 3 1s 9s 9 ethyl 5 fluoro 9 hydroxy 4 methyl 10 13 dioxo 2 3 9 10 13 15 hexahydro 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl carbamoyl cyclobutyl oxy 3 6 9 12 15 pentaoxo 2 5 8 11 14 pentaazaicosan 20 yl 2 5 dioxopyrrolidin 3 yl pamirtecan groups - H-gamma1 heavy chain humanized (1-449) \[VH (Homo sapiens IGHV3-66\*01 (81.6%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.13\] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K2>del (449)) (121-449)\], (223-214')-disulfide with L-kappa light chain humanized (1'-214') \[V-KAPPA (Homo sapiens IGKV1-39\*01 (86.3%) -IGKJ1\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of L-cysteinyl residues 223, 229, 232, 214', 223'', 229'', 232'' and 214''' with (3RS)-1-\[(7S)-7-benzyl-1-{\[(1R,3R)-3-{\[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo\[de\]pyrano\[3',4':6,7\]indolizino\[1,2-b\]quinolin-1-yl\]carbamoyl}cyclobutyl\]oxy}-3,6,9,12,15-pentaoxo-2,5,8,11,14-pentaazaicosan-20-yl\]-2,5-dioxopyrrolidin-3-yl (pamirtecan) groups - Immunoglobulin G1 \[de-450-lysine\], anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal DB-1303 γ1-chain), disulfide with human-Mus musculus monoclonal DB-1303 κ-chain, dimer, thioether with N-\[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl\]glycylglycyl-L-phenylalanyl-N-\[\[\[cis-3-\[\[\[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo\[de\]pyrano\[3′,4′:6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino\]carbonyl\]cyclobutyl\]oxy\]methyl\]glycinamide - immunoglobulin g1 de 450 lysine anti human epidermal growth factor receptor her2 human mus musculus monoclonal db 1303 γ1 chain disulfide with human mus musculus monoclonal db 1303 κ chain dimer thioether with n 6 3 mercapto 2 5 dioxo 1 pyrrolidinyl 1 oxohexyl glycylglycyl l phenylalanyl n cis 3 1s 9s 9 ethyl 5 fluoro 2 3 9 10 13 15 hexahydro 9 hydroxy 4 methyl 10 13 dioxo 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino carbonyl cyclobutyl oxy methyl glycinamide - immunoglobulin g1 kappa anti homo sapiens erbb2 receptor tyrosine protein kinase erbb 2 epidermal growth factor receptor 2 egfr2 her2 her 2 p185c erbb2 neu cd340 humanized monoclonal antibody conjugated on an average of eight cysteinyl residues to pamirtecan comprising a linker and a camptothecin derivative exatecan - immunoglobulin G1-kappa, anti-\[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)\], humanized monoclonal antibody,conjugated on an average of eight cysteinyl residues to pamirtecan, comprising a linker and a camptothecin derivative (exatecan) - trastuzumab pamirtecan - Trastuzumab pamirtecan - trastuzumab pamirtecan \[INN\] - TRASTUZUMAB PAMIRTECAN \[USAN\] - trastuzumab pamirtecan inn - trastuzumab pamirtecan usan ## Identifiers **CAS registry numbers** - 2792722-57-5 **ChEMBL ID** CHEMBL6068309 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068309) **FDA ingredient codes (UNII)** - WPL7XBK5KU ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-mab; -mab; -tecan ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (6) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005494 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0011962 **Highest recorded phase** 3 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSIRLSCAASGENIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRETISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVEPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVELFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPG - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 300 $ 300'' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428'' ## Related records ### Trials (4) - A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer - [A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors](https://trialight.com/data/trial/a-phase-1-2a-study-of-db-1303-bnt323-in-advanced-metastatic-eb87e354-fdbe-40fd-842a-91d4fc8c2107.md) - A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02) - A Study to Compare DB-1303/BNT323 Versus T-DM1 in Breast Cancer ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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