> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/trastuzumab-envedotin-83d8cfd5-016d-491f-8e0d-87666f69f461 > Record changed: 2026-10-29 # Trastuzumab envedotin Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068184) Drug type Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068184) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068184) ## Names and chemistry **Drug type** Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068184) **Drug name** Trastuzumab envedotin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068184) ### Other names (21) - arm 1 sirolimus for injection albumin bound dp303c - dp 303c - DP-303C - dp303c - Dp303c - DP303c - DP303c injection - h gamma1 heavy chain humanized 1 450 vh homo sapiens ighv3 66 01 81 6 ighd ighj4 01 100 cdr imgt 8 8 13 26 33 51 58 97 109 1 120 homo sapiens ighg1 03v g1m3 g1m17 ng1m1 ch1 k120 ch3 e12 m14 ch1 r120 k 217 121 218 hinge 1 15 219 233 ch2 234 343 ch3 e12 359 m14 361 344 448 chs 449 450 121 450 223 214 disulfide with l kappa light chain humanized 1 214 v kappa homo sapiens igkv1 39 01 86 3 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 229 229 232 232 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa substituted at the side chain nitrogen atom of l glutaminyl residues 298 and 298 with a radical group consisting of 6s 9s 1 amino 6 4 5s 8s 11s 12r 11 2s butan 2 yl 12 2 2s 2 1r 2r 3 1s 2r 1 hydroxy 1 phenylpropan 2 yl amino 1 methoxy 2 methyl 3 oxopropyl pyrrolidin 1 yl 2 oxoethyl 4 10 dimethyl 3 6 9 trioxo 5 8 di propan 2 yl 2 13 dioxa 4 7 10 triazatetradecyl phenyl carbamoyl 1 8 11 trioxo 9 propan 2 yl 13 16 19 trioxa 2 7 10 triazahenicosan 21 yl envedotin - H-gamma1 heavy chain humanized (1-450) \[VH (Homo sapiens IGHV3-66\*01 (81.6%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.13\] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1\*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)\], (223-214')-disulfide with L-kappa light chain humanized (1'-214') \[V-KAPPA (Homo sapiens IGKV1-39\*01 (86.3%) -IGKJ1\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')\]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the side chain nitrogen atom of L-glutaminyl residues 298 and 298'' with a radical group consisting of (6S,9S)-1-amino-6-({4-\[(5S,8S,11S,12R)-11-\[(2S)-butan-2-yl\]-12-(2-{(2S)-2-\[(1R,2R)-3-{\[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl\]amino}-1-methoxy-2-methyl-3-oxopropyl\]pyrrolidin-1-yl}-2-oxoethyl)-4,10-dimethyl-3,6,9-trioxo-5,8-di(propan-2-yl)-2,13-dioxa-4,7,10-triazatetradecyl\]phenyl}carbamoyl)-1,8,11-trioxo-9-(propan-2-yl)-13,16,19-trioxa-2,7,10-triazahenicosan-21-yl (envedotin) - immunoglobulin g1 anti human epidermal growth factor receptor her2 human mus musculus monoclonal dp001 γ1 chain disulfide with human mus musculus monoclonal dp001 κ chain dimer 298 298 diamide with n 4 n 2 2 2 2 aminoethoxy ethoxy ethoxy acetyl l valyl n5 aminocarbonyl l ornithyl amino phenyl methoxy carbonyl n methyl l valyl n 1s 2r 4 2s 2 1r 2r 3 1r 2s 2 hydroxy 1 methyl 2 phenylethyl amino 1 methoxy 2 methyl 3 oxopropyl 1 pyrrolidinyl 2 methoxy 1 1s 1 methylpropyl 4 oxobutyl n methyl l valinamide - immunoglobulin g1 kappa anti homo sapiens erbb2 receptor tyrosine protein kinase erbb 2 epidermal growth factor receptor 2 egfr2 her2 her 2 p185c erbb2 neu cd340 humanized monoclonal antibody conjugated at glutaminyl residues to monomethylauristatin e mmae with a ratio of 1 to 2 via a cleavable linker - immunoglobulin G1-kappa, anti-\[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)\], humanized monoclonal antibody, conjugated at glutaminyl residues to monomethylauristatin E (MMAE), with a ratio of 1 to 2, via a cleavable linker - Immunoglobulin G1, anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal DP001 γ1-chain), disulfide with human-Mus musculus monoclonal DP001 κ-chain, dimer, 298,298′-diamide with N-\[\[\[4-\[\[N-\[2-\[2-\[2-(2-aminoethoxy)ethoxy\]ethoxy\]acetyl\]-L-valyl-N5-(aminocarbonyl)-L-ornithyl\]amino\]phenyl\]methoxy\]carbonyl\]-N-methyl-L-valyl-N-\[(1S,2R)-4-\[(2S)-2-\[(1R,2R)-3-\[\[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl\]amino\]-1-methoxy-2-methyl-3-oxopropyl\]-1-pyrrolidinyl\]-2-methoxy-1-\[(1S)-1-methylpropyl\]-4-oxobutyl\]-N-methyl-L-valinamide - trastuzumab envedotin - Trastuzumab envedotin - trastuzumab envedotin \[INN\] - trastuzumab envedotin inn - trastuzumab envedotina - Trastuzumab envedotina - trastuzumab envedotine - Trastuzumab envedotine ## Identifiers **CAS registry numbers** - 2865132-89-2 **ChEMBL ID** CHEMBL6068184 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068184) **FDA ingredient codes (UNII)** - 37DMF82G1F ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-dotin; -mab; -mab ### Investigated indications (2) - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Breast Neoplasms **Highest recorded phase** 3 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 ### Open Targets indications (8) - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_1000294 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0003219 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005036 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 2 ### Trial references (3) - NCT05334810 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05334810) - NCT05901935 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05901935) - NCT05810103 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05810103) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGENIKDTYTHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGEYAMDYWGQGTLVTVSSASTKGPSVEPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLEPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPBNNYKTTPPVLDSDGSFFLYSKLTVDKSRWQGNVEFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 223-214' $ 223''-214''' $ 229-229'' $ 232-232''$ 264-324 $ 264''-324'' $ 370-428 $ 370''-428'' - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRESGSRSGTDFTLTISSLQPBDEFATYYCQHYTTPPTEGQGTKVELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSENRGEC - **Component** Glycosylation sites (N) **Sequence** 300 $ 300'' ## Related records ### Trials (8) - A PhaseⅠ/Ⅱ Study of Simmitinib or Irinotecan Liposomes Combined With DP303c in Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma - A Study of DP303c in Patients With HER2-positive Advanced Solid Tumors - [A Study of Sirolimus (Albumin-Bound) in Combination With Different ADCs Treatment of Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-sirolimus-albumin-bound-in-combination-with-191aa573-7e93-4d1d-9e6c-ea088bb8e0c2.md) - DP303c in Patients With HER2-positive Advanced Breast Cancer - DP303c in Patients With HER2-positive Unresectable Locally Advanced, Relapsed, or Metastaticbreast Cancer - DP303c Versus Trastuzumab Emtansine in in Patients With HER2-positive Advanced Breast Cancer - Study of DP303c Injection in Patients With Advanced or Metastatic Gastric Cancer - Study of DP303c Injection in Patients With Advanced Ovarian Cancer ### In development for (3) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3 - [HER2 positive breast carcinoma](https://trialight.com/data/condition/her2-positive-breast-carcinoma-eb8493ec-908e-5435-bf56-0d20c0c9bb88.md) Phase 3 - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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