> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/tranimilast-f3e61471-e3ce-4ce4-a7b2-bc52db5c9e47
> Record changed: 2026-11-04

# Tranimilast

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

**Drug name**

Tranimilast

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

**Molecular weight**

687.54

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

**Structure (SMILES)**

CS(=O)(=O)Nc1ccc(C(=O)O\[C@@H\](Cc2c(Cl)c\[n+\](\[O-\])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)cc1OCC1CC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

### Other names (18)

- chf 6001
- CHF 6001
- Chf-6001
- chf6001
- Chf6001
- CHF6001
- chf6001 3200µg
- CHF6001 3200µg
- j3 309 618f
- J3.309.618F
- tanimilast
- Tanimilast
- tanimilast \[INN\]
- tanimilast inn
- tranimilast
- Tranimilast
- TRANIMILAST \[USAN\]
- tranimilast usan

## Identifiers

**CAS registry numbers**

- 1239278-59-1

**ChEMBL ID**

CHEMBL3113974

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

**InChIKey**

VCFBPAOSTLMYIV-SANMLTNESA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3113974)

**PubChem compound IDs**

- 70662473

**FDA ingredient codes (UNII)**

- 0984EU6E2F

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-ast

### Mechanisms of action (4)

- **Mechanism**  
Phosphodiesterase 4 inhibitor

**Action type**  
Inhibitor

**Target**  
Phosphodiesterase 4

**Protein identifier**  
P27815
- **Mechanism**  
Phosphodiesterase 4 inhibitor

**Action type**  
Inhibitor

**Target**  
Phosphodiesterase 4

**Protein identifier**  
Q07343
- **Mechanism**  
Phosphodiesterase 4 inhibitor

**Action type**  
Inhibitor

**Target**  
Phosphodiesterase 4

**Protein identifier**  
Q08493
- **Mechanism**  
Phosphodiesterase 4 inhibitor

**Action type**  
Inhibitor

**Target**  
Phosphodiesterase 4

**Protein identifier**  
Q08499

### Open Targets mechanisms

- **Mechanism**  
Phosphodiesterase 4 inhibitor

**Action type**  
Inhibitor

**Target**  
Phosphodiesterase 4

### Investigated indications (2)

- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Asthma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004979

**Subject identifier**  
D001249

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005607

**Highest recorded phase**  
3

### Trial references (8)

- NCT01689571  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01689571)
- NCT01730404  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01730404)
- NCT02986321  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02986321)
- NCT03004495  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03004495)
- NCT04739774  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04739774)
- NCT04756960  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04756960)
- NCT05373953  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05373953)
- NCT06395610  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06395610)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

1

**Polar surface area**

127.1

**Calculated partition coefficient (ALogP)**

6.32

**Calculated partition coefficient (XLogP)**

5.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

15

**Heavy atoms**

45

**Molecular formula**

C30H30Cl2F2N2O8S

**Monoisotopic mass**

686.1067988

**Natural product**

No

## Evidence counts

**Recorded assays**

46

**Active assays**

12

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

4.48

**Mean**

4.48

**Minimum**

4.48

**Maximum**

4.48

**Unit**

unitless

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Plasma protein binding

**Median**

99.59

**Mean**

99.59

**Minimum**

99.2

**Maximum**

99.98

**Unit**

%

**Assays**

2

**Standard deviation**

0.551543

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- PPB

## Related records

### Trials (14)

- A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD
- A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
- A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER)
- A Comparison Study Between Adolescents With Asthma and Adults With Asthma on How They Absorb, Metabolise and Eliminate CHF 6001
- A Study to Evaluate the Efficacy After Allergen Challenge, Safety and Tolerability of Inhaled CHF6001 DPI in Asthmatics
- Clinical Study to Investigate the Pharmacokinetics, Safety and Tolerability Following Single Administration of CHF6001 in Subjects With Mild, Moderate and Severe Liver Impairment in Comparison With Matched Healthy Control Subjects
- Effect of Cyclosporine Drug Interaction on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers. Drug-Drug Interaction 2 (DDI2) Study
- Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers
- [Efficacy and Safety of Tanimilast in Asthmatics uNcontrolled on ICS-containinG backgrOund Maintenance Therapy](https://trialight.com/data/trial/efficacy-and-safety-of-tanimilast-in-asthmatics-uncontrolled-bfdc42f4-5b79-417d-bca1-42f55d51831a.md)
- Evaluation of the Absolute Bioavailability and Mass Balance of CHF6001 (Tanimilast) in Healthy Subjects
- Investigation of the Effect of Inhibition of CYP3A4/5 by Itraconazole on the PK of CHF6001 (Tanimilast)
- Pharmacodynamics, Pharmacokinetics and Safety of Two Doses of CHF6001 DPI in Subjects With Moderate, Severe COPD
- Pharmacokinetic Interaction and the Safety of Inhaled CHF5259 and CHF6001
- Safety, Tolerability and Efficacy of 28-day Inhaled CHF 6001 DPI in COPD Patients

### In development for (3)

- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2
- [Chronic bronchitis](https://trialight.com/data/condition/chronic-bronchitis-1182c6a7-3657-5c56-89e7-6c969a2220da.md) Phase 3
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 2

### Targets (4)

- [PDE4A](https://trialight.com/data/target/pde4a-87feb033-2b08-53fe-aafd-3f3b8635a7f8.md) Phosphodiesterase 4 inhibitor
- [PDE4B](https://trialight.com/data/target/pde4b-b6d2dead-6de9-505a-b969-9b1362d0de89.md) Phosphodiesterase 4 inhibitor
- [PDE4C](https://trialight.com/data/target/pde4c-430120be-12f2-5dfe-b97a-576e1cbfef79.md) Phosphodiesterase 4 inhibitor
- [PDE4D](https://trialight.com/data/target/pde4d-ea8f63af-69d9-547d-b6e2-cdb3f4d79d0f.md) Phosphodiesterase 4 inhibitor

---

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