> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tranexamic-acid-f50cb265-59c3-48c2-a9e1-1681168dfd0c > Record changed: 2026-11-04 # Tranexamic acid Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) First approval year 1986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) ## Development status **First approval year** 1986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) **Drug name** Tranexamic acid Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) **Molecular weight** 157.21 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) **Structure (SMILES)** NC\[C@H\]1CC\[C@H\](C(=O)O)CC1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) ### Brand names (12) - cyklo f heavy period relief - Cyklo-f heavy period relief - cyklokapron - Cyklokapron - exacyl - Exacyl - lysteda - Lysteda - menstralite - Menstralite - tranexamic acid - Tranexamic acid ### Other names (186) - 1 5g intravenous exacyl - 1 gram Tranexamic Acid (TXA) - 1 gram tranexamic acid txa - 1.5g intravenous Exacyl - acide tranexamique - Acide tranexamique - Acide Tranexamique - acido tranexamico - Acido tranexamico - Active comparator : Tranexamic Acid (Exacyl) - active comparator tranexamic acid exacyl - amcha - Amcha - apcc apcc txa - cl 65336 - CL 65336 - CL-65336 - cl65336 - CL65336 - Conventional Oral TXA (Tranexamic Acid) - conventional oral txa tranexamic acid - cyclo f - Cyclo-f - cyclocapron - Cyclocapron And 161 more, listed on the interactive page. ## Identifiers **ATC classification codes** - B02AA02 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) **CAS registry numbers** - 1197-18-8 **ChEMBL ID** CHEMBL877 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) **InChIKey** GYDJEQRTZSCIOI-LJGSYFOKSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL877) **RxNorm IDs (RxCUI)** - 10691 **FDA ingredient codes (UNII)** - 6T84R30KC1 ## Regulatory information ### United States **Applicant** PFIZER **Approval date** 30 Dec 1986 **Application number** NDA019281 ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Pharmacology name** tranexamic acid **Type** Synthetic organic **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral - Parenteral ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** plasminogen **Gene symbol** PLG **Protein identifier** P00747 **Median affinity** 3.6 **Affinity units** pIC50 **Primary target** Yes - **Mechanism** Plasminogen inhibitor **Action type** Inhibitor **Target** Plasminogen **Protein identifier** P00747 ### Open Targets mechanisms - **Mechanism** Plasminogen inhibitor **Action type** Inhibitor **Target** Plasminogen ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** PLG **Protein identifier** P00747 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (64) - **Condition** Astrocytoma **Highest recorded phase** 3 **Condition identifier** EFO:0000272 **Subject identifier** D001254 - **Condition** Wounds and Injuries **Highest recorded phase** 3 **Condition identifier** EFO:0000546 **Subject identifier** D014947 - **Condition** Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Subarachnoid Hemorrhage **Highest recorded phase** 2 **Condition identifier** EFO:0000713 **Subject identifier** D013345 - **Condition** Leiomyoma **Highest recorded phase** 3 **Condition identifier** EFO:0000731 **Subject identifier** D007889 - **Condition** Melanoma **Highest recorded phase** 3 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** Liver Cirrhosis **Highest recorded phase** 0.5 **Condition identifier** EFO:0001422 **Subject identifier** D008103 - **Condition** Hematologic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0001642 **Subject identifier** D019337 - **Condition** Coronary Disease **Highest recorded phase** 3 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Spinal Cord Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0003828 **Subject identifier** D013120 - **Condition** Brain Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0003833 **Subject identifier** D001932 - **Condition** Pain **Highest recorded phase** 3 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Epistaxis **Highest recorded phase** 2 **Condition identifier** EFO:0003895 **Subject identifier** D004844 - **Condition** Fractures, Bone **Highest recorded phase** 3 **Condition identifier** EFO:0003931 **Subject identifier** D050723 - **Condition** Melanosis **Highest recorded phase** 3 **Condition identifier** EFO:0003963 **Subject identifier** D008548 - **Condition** Hip Fractures **Highest recorded phase** 3 **Condition identifier** EFO:0003964 **Subject identifier** D006620 - **Condition** Skin Neoplasms **Highest recorded phase** 0.5 **Condition identifier** EFO:0004198 **Subject identifier** D012878 - **Condition** Aortic Aneurysm, Abdominal **Highest recorded phase** 3 **Condition identifier** EFO:0004214 **Subject identifier** D017544 - **Condition** Anemia **Highest recorded phase** 3 **Condition identifier** EFO:0004272 **Subject identifier** D000740 - **Condition** Scoliosis **Highest recorded phase** 3 **Condition identifier** EFO:0004273 **Subject identifier** D012600 - **Condition** Head and Neck Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0004284 **Subject identifier** D006258 - **Condition** Osteoarthritis, Knee **Highest recorded phase** 2 **Condition identifier** EFO:0004616 **Subject identifier** D020370 - **Condition** Pelvic Organ Prolapse **Highest recorded phase** 3 **Condition identifier** EFO:0004710 **Subject identifier** D056887 - **Condition** Hypotension **Highest recorded phase** 0.5 **Condition identifier** EFO:0005251 **Subject identifier** D007022 - **Condition** Cerebral Hemorrhage **Highest recorded phase** 2 **Condition identifier** EFO:0005669 **Subject identifier** D002543 And 39 more, listed on the interactive page. ### Open Targets indications (146) - **Condition identifier** EFO\_0000284 - **Condition identifier** EFO\_0000546 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000551 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000713 - **Condition identifier** EFO\_0000731 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001422 - **Condition identifier** EFO\_0001642 **Highest recorded phase** 2 - **Condition identifier** EFO\_0001645 **Highest recorded phase** 3 - **Condition identifier** EFO\_0002950 - **Condition identifier** EFO\_0003828 - **Condition identifier** EFO\_0003833 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003881 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003895 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003895 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003931 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003963 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003964 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004198 - **Condition identifier** EFO\_0004214 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004272 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004273 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004284 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004352 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004616 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004710 **Highest recorded phase** 3 And 121 more, listed on the interactive page. ### Reported adverse events (45) - **Event** acute generalised exanthematous pustulosis **Reports** 13 **Reporting signal score** 18.9047 - **Event** acute myocardial infarction **Reports** 31 **Reporting signal score** 42.8755 - **Event** anaphylactic reaction **Reports** 63 **Reporting signal score** 86.133 - **Event** anaphylactic shock **Reports** 28 **Reporting signal score** 40.4632 - **Event** angioedema **Reports** 26 **Reporting signal score** 16.7004 - **Event** asthenia **Reports** 3 **Reporting signal score** 18.776 - **Event** blood pressure decreased **Reports** 30 **Reporting signal score** 27.6611 - **Event** cerebral infarction **Reports** 21 **Reporting signal score** 23.6083 - **Event** cerebral venous sinus thrombosis **Reports** 6 **Reporting signal score** 21.5197 - **Event** coronary artery thrombosis **Reports** 10 **Reporting signal score** 28.3152 - **Event** deep vein thrombosis **Reports** 56 **Reporting signal score** 62.0821 - **Event** diarrhoea **Reports** 7 **Reporting signal score** 30.557 - **Event** drug hypersensitivity **Reports** 1 **Reporting signal score** 20.4824 - **Event** fall **Reports** 3 **Reporting signal score** 17.8469 - **Event** false negative investigation result **Reports** 5 **Reporting signal score** 19.8954 - **Event** fatigue **Reports** 3 **Reporting signal score** 44.0037 - **Event** generalised tonic-clonic seizure **Reports** 25 **Reporting signal score** 42.2017 - **Event** grand mal convulsion **Reports** 45 **Reporting signal score** 113.174 - **Event** haemoglobin decreased **Reports** 38 **Reporting signal score** 18.8101 - **Event** haemoglobin increased **Reports** 16 **Reporting signal score** 43.588 - **Event** haemorrhage **Reports** 54 **Reporting signal score** 59.2114 - **Event** hypotension **Reports** 59 **Reporting signal score** 22.666 - **Event** ischaemic stroke **Reports** 21 **Reporting signal score** 26.7 - **Event** melaena **Reports** 37 **Reporting signal score** 61.0184 - **Event** myoclonic epilepsy **Reports** 12 **Reporting signal score** 39.8546 And 20 more, listed on the interactive page. ### Trial references (199) - NCT00113568 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00113568) - NCT00375258 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00375258) - NCT00386308 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00386308) - NCT00401193 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00401193) - NCT00670345 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00670345) - NCT00809393 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00809393) - NCT01085006 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01085006) - NCT01136590 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01136590) - NCT01141127 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01141127) - NCT01228136 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01228136) - NCT01295294 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01295294) - NCT01338454 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01338454) - NCT01530399 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01530399) - NCT01622946 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01622946) - NCT01643135 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01643135) - NCT01846507 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01846507) - NCT01866943 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01866943) - NCT01881568 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01881568) - NCT01895101 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01895101) - NCT01937559 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01937559) - NCT02086500 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02086500) - NCT02094066 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02094066) - NCT02117128 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02117128) - NCT02153593 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02153593) - NCT02219152 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02219152) And 174 more, listed on the interactive page. ## Dosing **Dose** 10 mg/kg **Route** Intravenous **How often** 3 to 4 times daily for 2 to 8 days, immediately before tooth extraction ### Conditions of use - Infuse no more than 1 mL/minute to avoid hypotension ## Chemical properties **Hydrogen bond acceptors** 2 **Hydrogen bond donors** 2 **Polar surface area** 63.32 **Calculated partition coefficient (ALogP)** 0.84 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 2 **Heavy atoms** 11 **Molecular formula** C8H15NO2 **Natural product** Yes ## National Drug Codes - 0013-1114 - 0591-3720 - 14593-318 - 14789-115 - 23155-166 - 23155-524 - 23155-909 - 23155-910 - 25021-415 - 25021-418 - 42571-189 - 42571-314 - 43066-008 - 50268-772 - 55150-188 - 59651-839 - 60687-750 - 62559-265 - 65145-106 - 65219-534 - 67457-197 - 68083-160 - 68083-613 - 69918-301 - 71357-017 And 25 more, listed on the interactive page. ## Biological measurements These details could not be displayed. ## Related records ### Trials (679) - "Topical Tranexamic Acid With Flap Fixation: A Novel Approach to Minimize Post-operative Drainage and Surgical Site Infection in Patients Undergoing Modified Radical Mastectomy" - A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating of Melasma. - A Pediatric Trial Using Tranexamic Acid in Thrombocytopenia - A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery - A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery - A Randomized Comparison of Two Doses of Tranexamic Acid in Open-Heart Surgery - A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery - A Randomized Controlled Trial of Inhaled Tranexamic Acid for the Treatment of Pulmonary Hemorrhage in Cancer Patients - A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding - A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population - A Study to Assess the Independent Effects of 4-Factor Prothrombin Complex Concentrate and Tranexamic Acid on Bleeding/Pharmacodynamics in Healthy Participants - A Study to Evaluate LB1148 for Return of Bowel Function in Subjects Undergoing Bowel Resection - A Study to Evaluate LB1148 for Return of Gastrointestinal Function and Adhesions in Subjects Undergoing Bowel Resection - A Study to Evaluate the Safety, Tolerability and Efficacy of LB1148 for Subjects Undergoing Elective Bowel Resection - A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery - A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement - Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty - ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial. - Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) - Alteration of Thrombelastography and Coagulation Function in Patients Undergoing Total Knee Arthroplasty With Intra-articular Tranexamic Acid Administration ### Approved for (1) - [Hemophilia A](https://trialight.com/data/condition/hemophilia-a-f8870901-8872-5178-8d5a-e1fde5d3339e.md) ### In development for (57) - Abdominal aortic aneurysm Phase 3 - Anemia Phase 3 - Aortic aneurysm Phase 3 - [Arthropathy](https://trialight.com/data/condition/arthropathy-bbc05db6-678e-5b8c-abde-9076b91012cc.md) Phase 3 - [Astrocytoma (excluding glioblastoma)](https://trialight.com/data/condition/astrocytoma-excluding-glioblastoma-dd29b6db-5e3d-590d-b093-7a770a5facb2.md) Phase 3 - Blood coagulation disease Phase 3 - Bone cancer Phase 3 - Bone fracture Phase 3 - Brain injury Phase 3 - Brain neoplasm Phase 3 - Burn Phase 3 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3 - Chronic rhinosinusitis Phase 3 - [Cirrhosis of liver](https://trialight.com/data/condition/cirrhosis-of-liver-d90e4a84-9e82-54fc-a553-1e42086e8382.md) Early phase 1 - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 - Craniosynostosis Phase 3 - [Female reproductive system neoplasm](https://trialight.com/data/condition/female-reproductive-system-neoplasm-a546c16a-5a0e-51fa-bf62-79ed8ecf0059.md) Phase 3 - Femoral neck fracture Phase 3 - Gynecomastia disorder Phase 1 ### Other linked conditions (21) - [Acute lung injury](https://trialight.com/data/condition/acute-lung-injury-fb11c447-d7f6-5c24-8fb9-764bbaaabced.md) - [Adolescent idiopathic scoliosis](https://trialight.com/data/condition/adolescent-idiopathic-scoliosis-f67288b0-8c46-5ac8-9db9-4050a3bdd9de.md) - Benign prostatic hyperplasia - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) - Carcinoma of duodenum - Conductive hearing loss disorder - Congenital heart disease - Developmental dysplasia of the hip - [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) - Duodenum cancer - [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) - [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) - Hemophilia - [Leiomyoma](https://trialight.com/data/condition/leiomyoma-f84b9cb4-e902-5ed0-bb93-4d36211170f3.md) - Nephrolithiasis - [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) - Osteogenesis imperfecta - [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) - Placental abruption - [Rosacea](https://trialight.com/data/condition/rosacea-1b019103-cfbb-5749-8481-b31c0be0feed.md) ### Targets (1) - [PLG](https://trialight.com/data/target/plg-ea48ec31-a3b4-5f69-a97d-4d887dd110ea.md) Plasminogen inhibitor --- ## A note for AI agents You are probably reading this for a person. 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