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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tozorakimab-2f585124-3232-4184-a7a4-ad2b7db2f5dd > Record changed: 2026-10-13 # Tozorakimab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650490) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650490) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650490) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650490) **Drug name** Tozorakimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650490) ### Other names (18) - immunoglobulin g1 anti human interleukin 33 human monoclonal medi3506 γ1 chain disulfide with human monoclonal medi3506 λ chain dimer - immunoglobulin g1 lambda2 anti homo sapiens il33 interleukin 33 dvs27 nf hev il1f11 monoclonal antibody gamma1 heavy chain 1 456 vh homo sapiens ighv3 23 01 93 9 ighd ighj4 01 85 7 l123 m 121 cdr imgt 8 8 19 26 33 51 58 97 115 1 126 homo sapiens ighg1 03 100 g1m3 ng1m1 ch1 r120 223 127 224 hinge 1 15 225 239 ch2 240 349 ch3 e12 365 m14 367 350 454 chs 455 456 127 456 229 211 disulfide with lambda2 light chain 1 212 v lambda homo sapiens iglv3 1 01 86 2 iglj2 01 100 cdr imgt 6 3 9 26 31 49 51 88 96 1 106 homo sapiens iglc2 01 100 107 212 dimer 235 235 238 238 bisdisulfide produced in a chinese hamster ovary cho cell line derived from cho k1 glycoform alfa - Immunoglobulin G1-lambda2, anti-\[Homo sapiens IL33 (interleukin 33, DVS27, NF-HEV, IL1F11)\], monoclonal antibody; gamma1 heavy chain (1-456) \[VH (Homo sapiens IGHV3-23\*01 (93.9%) -(IGHD) -IGHJ4\*01 (85.7%) L123>M (121)) CDR-IMGT \[8.8.19\] (26-33.51-58.97-115) (1-126) -Homo sapiens IGHG1\*03 (100%) G1m3, nG1m1 (CH1 R120 (223) (127-224), hinge 1-15 (225-239), CH2 (240-349), CH3 E12 (365), M14 (367) (350-454), CHS (455-456)) (127-456)\], (229-211')-disulfide with lambda2 light chain (1'-212') \[V-LAMBDA (Homo sapiens IGLV3-1\*01 (86.2%) -IGLJ2\*01 (100%)) CDR-IMGT \[6.3.9\] (26-31.49-51.88-96) (1'-106') -Homo sapiens IGLC2\*01 (100%) (107'-212')\]; dimer (235-235'':238-238'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa - Immunoglobulin G1, anti-(human interleukin 33) (human monoclonal MEDI3506 γ1-chain), disulfide with human monoclonal MEDI3506 λ-chain, dimer - medi 3506 - Medi 3506 - MEDI-3506 - medi3506 - Medi3506 - MEDI3506 - tozorakimab - Tozorakimab - tozorakimab \[INN\] - TOZORAKIMAB \[USAN\] - Tozorakimab \[WHO-DD\] - tozorakimab inn - tozorakimab usan - tozorakimab who dd ## Identifiers **CAS registry numbers** - 2376858-66-9 **ChEMBL ID** CHEMBL4650490 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650490) **FDA ingredient codes (UNII)** - OHZ2MEL7FD ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** tozorakimab **Type** Antibody **Drug name stem** \-mab ### Mechanisms of action - **Action** Binding **Action type** Binding **Target** IL-33 **Gene symbol** IL-33 **Median affinity** 10.09 **Affinity units** pIC50 ### Investigated indications (6) - **Condition** Dermatitis, Atopic **Highest recorded phase** 2 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Pulmonary Disease, Chronic Obstructive **Highest recorded phase** 3 **Condition identifier** EFO:0000341 **Subject identifier** D029424 - **Condition** Diabetic Nephropathies **Highest recorded phase** 2 **Condition identifier** EFO:0000401 **Subject identifier** D003928 - **Condition** Bronchitis, Chronic **Highest recorded phase** 2 **Condition identifier** EFO:0006505 **Subject identifier** D029481 - **Condition** Dermatitis **Highest recorded phase** 1 **Condition identifier** HP:0011123 **Subject identifier** D003872 - **Condition** Asthma **Highest recorded phase** 2 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 ### Open Targets indications (11) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000341 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000401 **Highest recorded phase** 2 - **Condition identifier** EFO\_0006505 **Highest recorded phase** 2 - **Condition identifier** HP\_0011123 - **Condition identifier** MONDO\_0001208 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005002 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005016 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005607 **Highest recorded phase** 2 ### Trial references (8) - NCT03096795 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03096795) - NCT05158387 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05158387) - NCT05166889 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05166889) - NCT06040086 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06040086) - NCT04170543 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04170543) - NCT04212169 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04212169) - NCT04570657 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04570657) - NCT04631016 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04631016) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Heavy chain **Type** Protein **Sequence** EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGISAIDQSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQKFMQLWGGGLRYPFGYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Glycosylation sites (N) **Sequence** 306 $ 306'''' - **Component** Glycosylation sites (N) **Sequence** 306 $ 306'' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 22'-87' $ 22'''-87''' $ 134'-193' $ 134'''-193''' $ 153-209 $ 153''-209'' $ 229-211' $ 229''-211''' $ 235-235'' $ 238-238'' $ 270-330 $ 270''-330'' $ 376-434 $ 376''-434'' - **Component** Light chain **Type** Protein **Sequence** SYVLTQPPSVSVSPGQTASITCSGEGMGDKYAAWYQQKPGQSPVLVIYRDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCGVIQDNTGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS ## Related records ### Trials (16) - A Phase 2b Diabetic Kidney Disease Study - A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis - A Study to Investigate Efficacy and Safety of Tozorakimab Injections Compared With Placebo in Adult Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations and Elevated Eosinophils - A Study to Investigate Relative Bioavailability of Two Different Dosage Forms for Tozorakimab Via Subcutaneous Administration in Healthy Volunteers - [An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab](https://trialight.com/data/trial/an-accessorised-prefilled-syringe-to-an-autoinjector-2b184986-8faa-45e5-a990-9dd0cad603e3.md) - [Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids](https://trialight.com/data/trial/dose-range-finding-study-to-assess-efficacy-and-safety-of-bca6b71f-5bbc-44e0-b6e4-252cc8f2afd6.md) - Efficacy and Safety of MEDI3506 in Adult Subjects With Atopic Dermatitis - [Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen](https://trialight.com/data/trial/efficacy-and-safety-of-tozorakimab-in-patients-hospitalised-9c66d9ea-ce88-4df8-afdc-31bd8fe08b85.md) - [Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations](https://trialight.com/data/trial/efficacy-and-safety-of-tozorakimab-in-symptomatic-chronic-5d6a951d-a364-4c53-b356-d85ab81b2b3b.md) - [Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations](https://trialight.com/data/trial/efficacy-and-safety-of-tozorakimab-in-symptomatic-chronic-e718c89f-6f9c-424c-8c5b-9e014fff210b.md) - [Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.](https://trialight.com/data/trial/efficacy-and-safety-of-tozorakimab-in-symptomatic-chronic-29cdc88d-f51a-48ef-8069-daf850653413.md) - [Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).](https://trialight.com/data/trial/long-term-efficacy-and-safety-of-tozorakimab-in-participants-4faa95ab-298d-4a76-b9f8-19a7c6bb697d.md) - Long-term Safety and Tolerability of Tozorakimab in Patients With COPD and History of Exacerbations - Pharmacokinetics, Immunogenicity, Safety and Tolerability of MEDI3506 in Health Chinese Participants - Safety and Tolerability of MEDI3506 in Healthy Participants, in Participants With COPD and Healthy Japanese Participants - Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma ### In development for (7) - [Acute respiratory failure](https://trialight.com/data/condition/acute-respiratory-failure-a4d08df7-7f5c-558c-9da0-305072fe16fe.md) Phase 3 - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Chronic bronchitis](https://trialight.com/data/condition/chronic-bronchitis-1182c6a7-3657-5c56-89e7-6c969a2220da.md) Phase 2 - [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3 - [Dermatitis](https://trialight.com/data/condition/dermatitis-cf8b2157-f593-5138-bd3d-f2a74343308e.md) Phase 1 - [Diabetic kidney disease](https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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