> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tozinameran-bb0e4f65-bf06-4152-bd75-c7c1f5505a9d > Record changed: 2026-10-13 # Tozinameran Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) Drug type Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) First approval year 2020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) ## Development status **First approval year** 2020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) ## Names and chemistry **Drug type** Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) **Drug name** Tozinameran Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) ### Brand names (2) - comirnaty - Comirnaty ### Other names (44) - bnt 162b2 - BNT-162B2 - bnt162b2 - Bnt162b2 - BNT162b2 - BNT162B2 - BNT162b2 (B.1.1.529) - BNT162b2 (B.1.351) - BNT162b2 (Omi JN.1) - BNT162b2 (Omi KP.2) - BNT162b2 (Omi XBB.1.5) - BNT162b2 (Tozinameran) - BNT162b2 20mcg - BNT162b2 30mcg - BNT162b2 30μg - BNT162b2.B.1.351 - comirnaty - Comirnaty - COMIRNATY - Comirnaty (BTN162b2) - COMIRNATY intramuscular injection - comirnaty mrna - Comirnaty mrna - Comirnaty® - COMIRNATY® And 19 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 2417899-77-3 **ChEMBL ID** CHEMBL4650429 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650429) **RxNorm IDs (RxCUI)** - 2468230 **FDA ingredient codes (UNII)** - 5085ZFP6SJ ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-meran ### Mechanisms of action - **Mechanism** Spike glycoprotein vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Spike glycoprotein **Protein identifier** P0DTC2 ### Open Targets mechanisms - **Mechanism** Spike glycoprotein vaccine antigen **Action type** VACCINE ANTIGEN **Target** Spike glycoprotein ### Investigated indications (7) - **Condition** Infections **Highest recorded phase** 2 **Condition identifier** EFO:0000544 **Subject identifier** D007239 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 4 **Condition identifier** EFO:0000694 **Subject identifier** D045169 - **Condition** Vaccination **Highest recorded phase** 4 **Condition identifier** EFO:0004292 **Subject identifier** D014611 - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0004992 **Subject identifier** D009369 - **Condition** Hypersensitivity **Highest recorded phase** 2 **Condition identifier** MONDO:0005271 **Subject identifier** D006967 - **Condition** COVID-19 **Highest recorded phase** 4 **Condition identifier** MONDO:0100096 **Subject identifier** D000086382 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 4 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (31) - **Condition identifier** EFO\_0000694 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0002974 - **Condition identifier** MONDO\_0004952 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005062 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005100 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005109 - **Condition identifier** MONDO\_0005192 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005265 - **Condition identifier** MONDO\_0005271 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005301 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005554 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005575 - **Condition identifier** MONDO\_0006594 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007243 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007254 - **Condition identifier** MONDO\_0007256 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007915 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008054 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008315 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0011429 **Highest recorded phase** 2 And 6 more, listed on the interactive page. ### Reported adverse events (37) - **Event** acute macular neuroretinopathy **Reports** 2 **Reporting signal score** 12.0859 - **Event** bicytopenia **Reports** 9 **Reporting signal score** 32.0033 - **Event** catarrh **Reports** 3 **Reporting signal score** 12.2123 - **Event** cerebral venous thrombosis **Reports** 11 **Reporting signal score** 39.9965 - **Event** covid-19 **Reports** 16 **Reporting signal score** 18.0666 - **Event** covid-19 pneumonia **Reports** 24 **Reporting signal score** 87.7176 - **Event** cutaneous lupus erythematosus **Reports** 7 **Reporting signal score** 20.495 - **Event** deep vein thrombosis **Reports** 17 **Reporting signal score** 12.7557 - **Event** ear pruritus **Reports** 4 **Reporting signal score** 11.0627 - **Event** gravitational oedema **Reports** 4 **Reporting signal score** 13.5915 - **Event** hepatic cytolysis **Reports** 12 **Reporting signal score** 37.4803 - **Event** idiopathic inflammatory myopathy **Reports** 2 **Reporting signal score** 15.0172 - **Event** immune thrombocytopenia **Reports** 16 **Reporting signal score** 62.3939 - **Event** ischaemic stroke **Reports** 29 **Reporting signal score** 66.5488 - **Event** jugular vein thrombosis **Reports** 5 **Reporting signal score** 15.2547 - **Event** myocarditis **Reports** 13 **Reporting signal score** 29.7395 - **Event** myositis **Reports** 7 **Reporting signal score** 11.7451 - **Event** ophthalmic herpes zoster **Reports** 5 **Reporting signal score** 15.2547 - **Event** pancreatitis acute **Reports** 10 **Reporting signal score** 10.6669 - **Event** pericarditis **Reports** 10 **Reporting signal score** 17.5988 - **Event** petechiae **Reports** 8 **Reporting signal score** 14.2961 - **Event** piloerection **Reports** 4 **Reporting signal score** 15.3661 - **Event** portosplenomesenteric venous thrombosis **Reports** 2 **Reporting signal score** 11.0349 - **Event** pulmonary embolism **Reports** 59 **Reporting signal score** 100.697 - **Event** pyrexia **Reports** 42 **Reporting signal score** 16.1793 And 12 more, listed on the interactive page. ### Trial references (61) - NCT04368728 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04368728) - NCT04569383 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04569383) - NCT04588480 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04588480) - NCT04649021 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04649021) - NCT04713553 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04713553) - NCT04780659 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04780659) - NCT04800133 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04800133) - NCT04816643 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04816643) - NCT04816669 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04816669) - NCT04860739 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04860739) - NCT04889209 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04889209) - NCT04894435 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04894435) - NCT04895982 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04895982) - NCT04907331 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04907331) - NCT04949490 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04949490) - NCT04952402 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04952402) - NCT04955626 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04955626) - NCT04961229 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04961229) - NCT04969250 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04969250) - NCT05047640 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05047640) - NCT05049226 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05049226) - NCT05057169 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05057169) - NCT05057182 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05057182) - NCT05084989 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05084989) - NCT05124171 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05124171) And 36 more, listed on the interactive page. ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (142) - A Phase 1a Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19 - A Phase 1b Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19 - [A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults](https://trialight.com/data/trial/a-phase-2b-randomized-double-blind-active-controlled-study-e639bab6-2b83-4876-8779-8eefb6413bb9.md) - A Phase 3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Multiple Production Lots and Dose Levels of BNT162b2 RNA-Based COVID-19 Vaccines Against COVID-19 in Healthy Participants - A Phase I/II Study of GLB-COV2-043 as a COVID-19 Vaccine Booster - [A Phase I/II, Dose-finding Study to Assess the Safety, Reactogenicity, and Immunogenicity of a Broadly Protective Sarbecovirus Vaccine (GBP511) in Healthy Adults.](https://trialight.com/data/trial/a-phase-i-ii-dose-finding-study-to-assess-the-safety-506ad74f-aa12-4685-8b7e-267f12ad7c7b.md) - [A Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of SCTV01C and SCTV01E in Population Aged ≥12 Years Previously Fully Vaccinated With Inactivated COVID-19 Vaccine](https://trialight.com/data/trial/a-phase-ii-clinical-trial-to-evaluate-the-immunogenicity-and-6bfdab8c-4270-4858-8f91-48a7ee1212f5.md) - [A Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of SCTV01C in Population Aged ≥18 Years and Previously Fully Vaccinated With COVID-19 Vaccine](https://trialight.com/data/trial/a-phase-ii-clinical-trial-to-evaluate-the-immunogenicity-and-c9fc6305-f010-4827-a6bc-2acd417350e5.md) - [A Phase II Clinical Trial to Evaluate the Immunogenicity and Safety of SCTV01E in Population Aged ≥18 Years Previously Fully Vaccinated With mRNA COVID-19 Vaccine](https://trialight.com/data/trial/a-phase-ii-clinical-trial-to-evaluate-the-immunogenicity-and-69e65b50-ca6a-4a04-a1a9-86fb1f65cb21.md) - A Real-world Evidence Study of BNT162b2 mRNA Covid-19 Vaccine Among Children in Brazil - A Real-world Evidence Study of BNT162b2 mRNA Covid-19 Vaccine in Brazil - A Study of the Immunogenicity and Safety of SCTV01C in Population Aged ≥12 Years and Previously Vaccinated With Inactivated COVID-19 Vaccine - A Study to Evaluate Safety, Tolerability, & Immunogenicity of Multiple Formulations of BNT162b2 Against COVID-19 in Healthy Adults - [A Study to Evaluate the Immunogenicity and Safety of a Recombinant Protein COVID-19 Vaccine in Population Aged ≥18 Years](https://trialight.com/data/trial/a-study-to-evaluate-the-immunogenicity-and-safety-of-a-3c407664-1f1f-4ec2-800c-17b350fe11df.md) - [A Study to Evaluate the Immunogenicity and Safety of Two Recombinant Protein COVID-19 Vaccines in Population Aged ≥18 Years as Booster Vaccines](https://trialight.com/data/trial/a-study-to-evaluate-the-immunogenicity-and-safety-of-two-52c2b3bc-49a2-45ef-b947-228c5785a047.md) - [A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Combined Modified RNA Vaccine Candidates Against COVID-19 and Influenza](https://trialight.com/data/trial/a-study-to-evaluate-the-safety-tolerability-and-108e8f6b-c713-46ad-8336-9d801e475407.md) - [A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection](https://trialight.com/data/trial/a-study-to-evaluate-vxa-cov2-3-3-covid-19-vaccine-against-373ecde0-f8ab-48df-8b85-96c94b814af8.md) - [A Study to Learn About a Combined COVID-19 and Influenza Shot in Healthy Adults](https://trialight.com/data/trial/a-study-to-learn-about-a-combined-covid-19-and-influenza-ec5c534d-797c-4a8d-893a-b6e5d2259438.md) - A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age - [A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age](https://trialight.com/data/trial/a-study-to-learn-about-a-covid-19-vaccine-in-healthy-adults-9c35986f-ab6e-41ab-99b4-71851358999b.md) ### Approved for (2) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) - [Severe acute respiratory syndrome](https://trialight.com/data/condition/severe-acute-respiratory-syndrome-7654d02a-f750-52a0-bec2-afe3b4b3c224.md) ### In development for (2) - Allergic disease Phase 2 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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