> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/tovinontrine-ff9f7ef0-b403-4b10-aaee-d81896455f2e
> Record changed: 2026-10-13

# Tovinontrine

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

**Drug name**

Tovinontrine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

**Molecular weight**

394.48

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

**Structure (SMILES)**

C\[C@@H\]1CN(Cc2ncccn2)C\[C@H\]1c1cn2c(C3CCOCC3)ncc2c(=O)\[nH\]1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

### Other names (26)

- 68722
- af 68722
- AF-68722
- af68722
- AF68722
- ck 1598
- CK-1598
- ck1598
- CK1598
- imr 687
- Imr-687
- IMR-687
- tovinontrina
- Tovinontrina
- TOVINONTRINA
- tovinontrine
- Tovinontrine
- TOVINONTRINE
- Tovinontrine (CRD-750
- Tovinontrine (CRD-750)
- tovinontrine \[INN\]
- TOVINONTRINE \[USAN\]
- Tovinontrine \[WHO-DD\]
- tovinontrine inn
- tovinontrine usan

And 1 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2062661-53-2

**ChEMBL ID**

CHEMBL4297290

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

**InChIKey**

GWGNPYYVGANHRJ-GDBMZVCRSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297290)

**PubChem compound IDs**

- 124220601

**FDA ingredient codes (UNII)**

- W248Y1AKOR

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-nontrine; -vin-

### Mechanisms of action

- **Mechanism**  
Phosphodiesterase 9A inhibitor

**Action type**  
Inhibitor

**Target**  
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

**Protein identifier**  
O76083

### Open Targets mechanisms

- **Mechanism**  
Phosphodiesterase 9A inhibitor

**Action type**  
Inhibitor

**Target**  
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

### Investigated indications (3)

- **Condition**  
Heart Failure

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003144

**Subject identifier**  
D006333
- **Condition**  
Anemia, Sickle Cell

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0011382

**Subject identifier**  
D000755
- **Condition**  
beta-Thalassemia

**Highest recorded phase**  
2

**Condition identifier**  
Orphanet:848

**Subject identifier**  
D017086

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0003144

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005252

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011382

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019402

**Highest recorded phase**  
2
- **Condition identifier**  
Orphanet\_848

**Highest recorded phase**  
2

### Trial references (6)

- NCT02998450  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02998450)
- NCT03401112  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03401112)
- NCT04053803  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04053803)
- NCT04474314  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04474314)
- NCT04411082  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04411082)
- NCT05312021  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05312021)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

1

**Polar surface area**

88.41

**Calculated partition coefficient (ALogP)**

1.94

**Calculated partition coefficient (XLogP)**

0.4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

4

**Heavy atoms**

29

**Molecular formula**

C21H26N6O2

**Monoisotopic mass**

394.21172409

**Natural product**

No

## Evidence counts

**Recorded assays**

9

**Active assays**

9

### Active assay types

- Confirmatory

## Related records

### Trials (8)

- A Study of IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia)
- A Study of IMR-687 in Healthy Adult Volunteers
- A Study of IMR-687 in Subjects With Beta Thalassemia
- A Study of IMR-687 in Subjects With Sickle Cell Disease
- [A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)](https://trialight.com/data/trial/a-study-to-assess-safety-effectiveness-of-tovinontrine-in-a502fdf6-1cf8-4a89-a30d-2a699a7e703f.md)
- An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia
- [Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)](https://trialight.com/data/trial/safety-effectiveness-of-tovinontrine-in-chronic-heart-2e2f0384-3fe5-467b-a9a7-d6661cca7caa.md)
- Selective PDE9 Inhibition With IMR-687 in Adults With Heart Failure With Preserved Ejection Fraction

### In development for (3)

- Beta thalassemia Phase 2
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 2
- Sickle cell disease Phase 2

### Targets (1)

- [PDE9A](https://trialight.com/data/target/pde9a-77bc51ad-da74-5414-a8bc-1854411e630e.md) Phosphodiesterase 9A inhibitor

---

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