> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tobevibart-a954f692-7e1e-467d-8ac7-490c08ca64d4 > Record changed: 2026-10-13 # Tobevibart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314621) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314621) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314621) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314621) **Drug name** Tobevibart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314621) ### Other names (17) - hbc34 v35 ls xx2 - HBC34-v35-LS-XX2 - Immunoglobulin G1 \[238-alanine,332-leucine,334-glutamic acid,430-leucine,436-serine\], anti-(hepatitis B virus surface antigen) (human monoclonal VIR-3434 γ1-chain), disulfide with human monoclonal VIR-3434 λ-chain, dimer - immunoglobulin g1 238 alanine 332 leucine 334 glutamic acid 430 leucine 436 serine anti hepatitis b virus surface antigen human monoclonal vir 3434 γ1 chain disulfide with human monoclonal vir 3434 λ chain dimer - ls gaalie - LS-GAALIE - tobevibart - Tobevibart - tobevibart \[INN\] - TOBEVIBART \[USAN\] - tobevibart inn - tobevibart usan - vir 3434 - Vir-3434 - VIR-3434 - vir3434 - VIR3434 ## Identifiers **CAS registry numbers** - 2645440-65-7 **ChEMBL ID** CHEMBL5314621 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314621) **FDA ingredient codes (UNII)** - PL93ZHC4L3 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications (3) - **Condition** Hepatitis B **Highest recorded phase** 1 **Condition identifier** EFO:0004197 **Subject identifier** D006509 - **Condition** Hepatitis B, Chronic **Highest recorded phase** 2 **Condition identifier** EFO:0004239 **Subject identifier** D019694 - **Condition** Hepatitis D **Highest recorded phase** 2 **Condition identifier** EFO:0007304 **Subject identifier** D003699 ### Open Targets indications (6) - **Condition identifier** EFO\_0004197 **Highest recorded phase** 1 - **Condition identifier** EFO\_0004239 **Highest recorded phase** 2 - **Condition identifier** EFO\_0007304 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005344 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005366 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005789 **Highest recorded phase** 3 ### Trial references (5) - NCT04423393 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04423393) - NCT04856085 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04856085) - NCT05612581 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05612581) - NCT06216470 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06216470) - NCT05461170 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05461170) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** ELQLVESGGGWVQPGGSQRLSCAASGRIFRSFYMSWVRQAPGKGLEWVATINQDGSEKLYVDSVKGRFTISRDNAKNSLFLQMNNLRVEDTAVYYCAAWSGNSGGMDVWGQGTTVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPLPEEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22'-87' $ 22'''-87''' $ 22-96 $ 22''-96'' $ 134'-193' $ 134'''-193''' $ 146-202 $ 146''-202'' $ 222-211' $ 222''-211'' $ 228-228'' $ 231-231'' $ 263-323 $ 263''-323'' $ 369-427 $ 369''-427'' - **Component** Light chain **Type** Protein **Sequence** SYELTQPPSVSVSPGQTVSIPCSGDKLGNKNVAWFQHKPGQSPVLVIYEVKYRPSGIPERFSGSNSGNTATLTISGTQAMDEAAYFCQTFDSTTVVFGGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS - **Component** Glycosylation sites (N) **Sequence** 299 $ 299'' ## Related records ### Trials (10) - A Platform Study to Evaluate Investigational Therapies in Chronic Hepatitis B Infection - A Study to Evaluate Tobevibart + Elebsiran in Chronic HDV Infection - A Study to Evaluate Tobevibart+Elebsiran in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide - A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection - Dose-Escalation Prime/Boost Therapeutic Vaccination Study Of 2 Chimp Adenoviral Vectors in Adults With Chronic HBV On Nucleos(t)Ide Therapy - [Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434](https://trialight.com/data/trial/effect-of-hepatic-impairment-on-the-pharmacokinetics-and-cf7d69e2-9032-423c-87d9-ae3834f7ef8d.md) - SOLSTICE: Combination Therapy for the Treatment of Chronic Hepatitis D Infection. - Study of VIR-2218, VIR-3434, and/or PEG-IFNα in Subjects With Chronic Hepatitis B Virus Infection - Study of VIR-3434 in Healthy Volunteers and Patients With Chronic Hepatitis B Virus Infection - Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection \[VISION\] ### In development for (3) - [Chronic hepatitis B virus infection](https://trialight.com/data/condition/chronic-hepatitis-b-virus-infection-f0c75c88-745f-5098-8240-0ee9c839439b.md) Phase 2 - [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) Phase 1 - Hepatitis D virus infection Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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