> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tixagevimab-188c0fce-c9b1-4577-9ae8-45c9393a429b > Record changed: 2026-10-13 # Tixagevimab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650265) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650265) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650265) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650265) **Drug name** Tixagevimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650265) ### Other names (22) - 2196 - azd 8895 - AZD-8895 - azd8895 - AZD8895 - AZD8895 (cell pool material) - AZD8895 (clonal cell line material) - azd8895 cell pool material - cov2 2196 - COV2-2196 - IMMUNOGLOBULIN G1 (240-THREONINE,241-METHIONINE,308-TYROSINE,310-THREONINE,312-GLUTAMIC ACID), ANTI-(SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 SPIKE GLYCOPROTEIN RECEPTOR-BINDING DOMAIN) (HUMAN MONOCLONAL AZD8895 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AZD8895 .KAPPA.-CHAIN, DIMER - immunoglobulin g1 240 threonine 241 methionine 308 tyrosine 310 threonine 312 glutamic acid anti severe acute respiratory syndrome coronavirus 2 spike glycoprotein receptor binding domain human monoclonal azd8895 gamma 1 chain disulfide with human monoclonal azd8895 kappa chain dimer - tixagevimab - Tixagevimab - tixagevimab \[INN\] - TIXAGEVIMAB \[JAN\] - TIXAGEVIMAB \[USAN\] - Tixagevimab \[WHO-DD\] - tixagevimab inn - tixagevimab jan - tixagevimab usan - tixagevimab who dd ## Identifiers **CAS registry numbers** - 2420564-02-7 **ChEMBL ID** CHEMBL4650265 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650265) **RxNorm IDs (RxCUI)** - 2587300 **FDA ingredient codes (UNII)** - F0LZ415Z3B ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** tixagevimab **Type** Antibody **Drug name stem** \-mab **Approval recorded by Guide to Pharmacology** Yes ### Mechanisms of action - **Mechanism** Spike glycoprotein blocker **Action type** Blocker **Target** Spike glycoprotein **Protein identifier** P0DTC2 ### Open Targets mechanisms - **Mechanism** Spike glycoprotein blocker **Action type** Blocker **Target** Spike glycoprotein ### Investigated indications (2) - **Condition** COVID-19 **Highest recorded phase** 1 **Condition identifier** MONDO:0100096 **Subject identifier** D000086382 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 3 ### Trial references (4) - NCT05166421 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05166421) - NCT05321394 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05321394) - NCT05375760 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05375760) - NCT05438498 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05438498) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Glycosylation sites (N) **Sequence** Asn-303 $ Asn-303'''' - **Component** Heavy chain **Type** Protein **Sequence** QMQLVQSGPEVKKPGTSVKVSCKASGFTFMSSAVQWVRQARGQRLEWIGWIVIGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSSISCNDGFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSRGWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-89' $ 23'''-89''' $ 101-106 $ 101''-106'' $ 136'-196' $ 136'''-196''' $ 150-206 $ 150''-206'' $ 216'-226 $ 216'''-226'' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431'' - **Component** Glycosylation sites (N) **Sequence** Asn-303 $ Asn-303'' ## Related records ### Trials (6) - A Randomized, Open-label, Dose-ranging Study in Adults and Pediatric Individuals ≥ 12 Years of Age to Assess the Safety, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AZD7442, for Pre-exposure Prophylaxis of COVID-19 - EVALUATION OF DIFFERENT PROPHYLACTIC INTERVENTIONS TOWARD COVID-19 IN SOLID ORGAN TRANSPLANT PATIENTS - Non-inferiority Trial on Treatments in Early COVID-19 - Real World Evaluation of the Effectiveness of AZD7442 for Prevention of SARS-CoV-2 - Study of Tixagevimab/Cilgavimab and Regdanvimab Efficacy for Treatment of COVID-19 - [Study to Evaluate Pharmacokinetic Comparability Between AZD7442 Co-formulation (AZD8895 + AZD1061) vs AZD8895 and AZD1061 Individually in Adult Healthy Participants](https://trialight.com/data/trial/study-to-evaluate-pharmacokinetic-comparability-between-7ef1ab39-bc99-4b20-bd6c-183e67a67347.md) ### In development for (1) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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