> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tivozanib-a703ca7a-f620-4d6d-8803-f01a7514a28d > Record changed: 2026-10-13 # Tivozanib Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) First approval year 2017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) ## Development status **First approval year** 2017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) **Drug name** Tivozanib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) **Molecular weight** 454.87 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) **Structure (SMILES)** COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) ### Other names (37) - asp 4130 - ASP-4130 - av 951 - AV-951 - dc 001164tivozanibav9511 2 chloro 4 6 7 dimethoxyquinolin 4 yl oxy phenyl 3 5 methylisoxazo 3 yl urea - DC-001164TIVOZANIBAV9511-(2-CHLORO-4((6,7-DIMETHOXYQUINOLIN-4-YL)OXY)PHENYL)-3-(5-METHYLISOXAZO-3-YL)UREA - fotivda - FOTIVDA - kil 8951 - Kil-8951 - KIL-8951 - kil8951 - KIL8951 - krn 951 - Krn-951 - KRN-951 - krn951 - KRN951 - ophthotech - OPHTHOTECH - tivozanib - Tivozanib - TIVOZANIB - TIVOZANIB (AV-951) - TIVOZANIB (OPHTHALMIC) And 12 more, listed on the interactive page. ## Identifiers **ATC classification codes** - L01EK03 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) **CAS registry numbers** - 475108-18-0 **ChEMBL ID** CHEMBL1289494 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) **InChIKey** SPMVMDHWKHCIDT-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1289494) **PubChem compound IDs** - 9911830 **RxNorm IDs (RxCUI)** - 2534233 **FDA ingredient codes (UNII)** - 172030934T ## Regulatory information ### United States **Applicant** AVEO PHARMS **Approval date** 10 Mar 2021 **Application number** NDA212904 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** tivozanib **Type** Synthetic organic **Drug name stem** \-anib **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (6) - **Action** Inhibition **Action type** Inhibitor **Target** fms related receptor tyrosine kinase 1 **Gene symbol** FLT1 **Protein identifier** P17948 **Median affinity** 9.68 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** fms related receptor tyrosine kinase 4 **Gene symbol** FLT4 **Protein identifier** P35916 **Median affinity** 9.62 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** kinase insert domain receptor **Gene symbol** KDR **Protein identifier** P35968 **Median affinity** 9.8 **Affinity units** pIC50 **Primary target** Yes - **Mechanism** Vascular endothelial growth factor receptor inhibitor **Action type** Inhibitor **Target** Vascular endothelial growth factor receptor **Protein identifier** P17948 - **Mechanism** Vascular endothelial growth factor receptor inhibitor **Action type** Inhibitor **Target** Vascular endothelial growth factor receptor **Protein identifier** P35916 - **Mechanism** Vascular endothelial growth factor receptor inhibitor **Action type** Inhibitor **Target** Vascular endothelial growth factor receptor **Protein identifier** P35968 ### Open Targets mechanisms (3) - **Mechanism** Platelet-derived growth factor receptor beta inhibitor **Action type** Inhibitor **Target** Platelet-derived growth factor receptor beta - **Mechanism** Stem cell growth factor receptor inhibitor **Action type** Inhibitor **Target** Mast/stem cell growth factor receptor Kit - **Mechanism** Vascular endothelial growth factor receptor inhibitor **Action type** Inhibitor **Target** Vascular endothelial growth factor receptor ### DrugCentral mechanisms (8) - **Action type** Inhibitor **Gene symbol** MET **Protein identifier** P08581 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** PDGFRB **Protein identifier** P09619 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** KIT **Protein identifier** P10721 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FGFR1 **Protein identifier** P11362 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FLT1 **Protein identifier** P17948 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FLT4 **Protein identifier** P35916 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** KDR **Protein identifier** P35968 **Organism** Homo sapiens **Target development level** Clinical - **Action type** Inhibitor **Gene symbol** FLT3 **Protein identifier** P36888 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (13) - **Condition** Carcinoma, Hepatocellular **Highest recorded phase** 2 **Condition identifier** EFO:0000182 **Subject identifier** D006528 - **Condition** Glioblastoma **Highest recorded phase** 2 **Condition identifier** EFO:0000519 **Subject identifier** D005909 - **Condition** Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 3 **Condition identifier** EFO:0000681 **Subject identifier** D002292 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 1 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Cholangiocarcinoma **Highest recorded phase** 1 **Condition identifier** EFO:0005221 **Subject identifier** D018281 - **Condition** Carcinoma, Renal Cell **Highest recorded phase** 3 **Condition identifier** EFO:0005708 **Subject identifier** D002292 - **Condition** Sarcoma **Highest recorded phase** 2 **Condition identifier** EFO:1001968 **Subject identifier** D012509 - **Condition** Fallopian Tube Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0002158 **Subject identifier** D005185 - **Condition** Colorectal Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0005575 **Subject identifier** D015179 - **Condition** Breast Neoplasms **Highest recorded phase** 1 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Ovarian Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0008170 **Subject identifier** D010051 - **Condition** Prostatic Neoplasms, Castration-Resistant **Highest recorded phase** 2 **Condition identifier** MONDO:0008315 **Subject identifier** D064129 ### Open Targets indications (27) - **Condition identifier** EFO\_0000182 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000519 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0000681 - **Condition identifier** EFO\_0003060 - **Condition identifier** EFO\_0005708 **Highest recorded phase** 3 - **Condition identifier** EFO\_1001968 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002158 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0003060 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005005 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005070 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005086 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005220 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005549 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0007256 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008315 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0015686 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0017884 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0017885 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0018078 **Highest recorded phase** 2 And 2 more, listed on the interactive page. ### Reported adverse events (3) - **Event** disease progression **Reports** 5 **Reporting signal score** 9.66673 - **Event** sepsis **Reports** 5 **Reporting signal score** 10.7188 - **Event** sinus tachycardia **Reports** 4 **Reporting signal score** 13.0715 ### Trial references (24) - NCT00502307 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00502307) - NCT00563147 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00563147) - NCT01030783 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01030783) - NCT01076010 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01076010) - NCT01297244 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01297244) - NCT01673386 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01673386) - NCT01834183 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01834183) - NCT03136627 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03136627) - NCT00660153 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00660153) - NCT01478594 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01478594) - NCT00717340 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00717340) - NCT00826878 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00826878) - NCT01728181 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01728181) - NCT01210846 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01210846) - NCT01782313 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01782313) - NCT01807156 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01807156) - NCT01835223 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01835223) - NCT03970616 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03970616) - NCT01846871 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01846871) - NCT01853644 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01853644) - NCT01885949 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01885949) - NCT04645160 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04645160) - NCT04987203 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04987203) - NCT06053658 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06053658) ## Dosing **Dose** 1.34 mg **Route** Oral **How often** 21 days on treatment followed by 7 days off treatment every 28 days ### Conditions of use (3) - Do not open capsule - Swallow capsule whole with water - Take with or without food ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 2 **Polar surface area** 107.74 **Calculated partition coefficient (ALogP)** 5.64 **Calculated partition coefficient (XLogP)** 4 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 6 **Heavy atoms** 32 **Molecular formula** C22H19ClN4O5 **Monoisotopic mass** 454.1043974 **Natural product** Yes ## Evidence counts **Recorded assays** 1,686 **Active assays** 249 ### Active assay types (3) - Confirmatory - Other - Screening ## Pharmacologic actions - Protein Kinase Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D047428.html) ## Related records ### Trials (167) - A Biomarker Study of Tivozanib in Subjects With Advanced Renal Cell Carcinoma - A Cardiac Safety Study of Tivozanib to Evaluate the Electrocardiogram and Pharmacokinetic-Electrocardiogram Dynamics in Subjects With Advanced Solid Tumors - A Multicenter Study Assessing the Efficacy and Safety of STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared With Vehicle in Subjects With Fuchs Endothelial Corneal Dystrophy (FECD) - A Pharmacokinetics (PK) Study in Healthy Adults - A Phase 1 Study to Evaluate The Effect of Ketoconazole on the Pharmacokinetics of Tivozanib in Healthy Subjects - A Phase 1 Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Tivozanib in Healthy Subjects - A Phase 1b, Open-Label, Dose-Finding Study to Evaluate the Safety of Tivozanib (AV-951) in Combination With Temsirolimus in Subjects With Metastatic Renal Cell Carcinoma - A Phase 1b/2a, Open-Label, Multi-Center Study of Tivozanib (AV-951) in Combination With Paclitaxel in Subjects With Advanced or Metastatic Breast Cancer - A Phase 2 Double-masked Study of VVN539 in Subjects With Elevated Intraocular Pressure - A Phase 2 Study of RCI001 Ophthalmic Solution in Participants With Dry Eye Disease - A Phase 2 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis - A Phase 3 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis - A Phase 3, Multi-Center Study Evaluating PL9643 in Patients with Dry Eye - A Phase I/II Study of Tivozanib and Erlotinib as Initial Treatment for Metastatic Non-small Cell Lung Cancer Assigned by VeriStrat® Serum Proteomic Evaluation - A Phase II Study of STSP-0902 Ophthalmic Solution in Patients With Neurotrophic Keratitis - A Phase II Study of Tivozanib in Patients With Metastatic and Non-resectable Soft Tissue Sarcomas - A Randomized, Open-label, Active-controlled, Phase 2a Clinical Trial to Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-angle Glaucoma or Ocular Hypertension - A Rollover Protocol to Allow Continued Access to Tivozanib (AV 951) for Subjects Enrolled in Other Tivozanib Protocols - A Safety Study of IVMED-85 Ophthalmic Solution in Healthy Adults - A Safety, Efficacy and Pharmacokinetic Study of AGN-199201 and AGN-190584 in Patients With Presbyopia ### In development for (13) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1 - [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 1 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2 - [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 2 - Glioblastoma Phase 2 - [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 2 - Neoplasm Phase 3 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1 - [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 2 - [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 2 - Renal cell adenocarcinoma Phase 3 - [Renal cell carcinoma](https://trialight.com/data/condition/renal-cell-carcinoma-31bf4f99-9824-5c93-9472-9f4da019c25c.md) Phase 3 - [Soft tissue sarcoma](https://trialight.com/data/condition/soft-tissue-sarcoma-3abd95b0-f8eb-5f0b-9e18-b37874e7f988.md) Phase 2 ### Targets (5) - [FLT1](https://trialight.com/data/target/flt1-2cfcec95-3fff-5be9-8423-701697547fa0.md) Vascular endothelial growth factor receptor inhibitor - [FLT4](https://trialight.com/data/target/flt4-c94058e2-ff1e-553b-92a5-8e7ee9305a80.md) Vascular endothelial growth factor receptor inhibitor - [KDR](https://trialight.com/data/target/kdr-4ab08263-0477-533e-ac3f-96e20d343c4b.md) Vascular endothelial growth factor receptor inhibitor - [KIT](https://trialight.com/data/target/kit-4430e375-befc-5469-b7bf-a28dfc518a97.md) Stem cell growth factor receptor inhibitor - [PDGFRB](https://trialight.com/data/target/pdgfrb-b0fcbfa5-50cf-5648-aa6d-c7487708468d.md) Platelet-derived growth factor receptor beta inhibitor --- ## A note for AI agents You are probably reading this for a person. 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