> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tirofiban-922283ae-e04a-47c1-9941-cc6846a3635c > Record changed: 2026-11-04 # Tirofiban Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) First approval year 1998 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) ## Development status **First approval year** 1998 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) **Drug name** Tirofiban Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) **Molecular weight** 440.61 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) **Structure (SMILES)** CCCCS(=O)(=O)N\[C@@H\](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) ### Other names (14) - agrastat - Agrastat - tirofiban - Tirofiban - TIROFIBAN \[HSDB\] - tirofiban \[INN\] - TIROFIBAN \[MI\] - TIROFIBAN \[VANDF\] - Tirofiban \[WHO-DD\] - tirofiban hsdb - tirofiban inn - tirofiban mi - tirofiban vandf - tirofiban who dd ## Identifiers **ATC classification codes** - B01AC17 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) **CAS registry numbers** - 144494-65-5 **ChEMBL ID** CHEMBL916 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) **InChIKey** COKMIXFXJJXBQG-NRFANRHFSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL916) **FDA ingredient codes (UNII)** - GGX234SI5H ### PubChem compound IDs (2) - 60947 - 40466968 ### RxNorm IDs (RxCUI) (2) - 73137 - 253202 ## Regulatory information ### United States **Applicant** MEDICURE **Approval date** 14 May 1998 **Application number** NDA020912 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Pharmacology name** tirofiban **Type** Synthetic organic **Drug name stem** \-fiban **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (2) - **Action** Inhibition **Action type** Inhibitor **Target** integrin αIIbβ3 **Gene symbol** ITGA2B **Protein identifier** P05106 **Median affinity** 9.43 **Affinity units** pIC50 **Primary target** Yes - **Action** Inhibition **Action type** Inhibitor **Target** integrin αIIbβ3 **Gene symbol** ITGB3 **Protein identifier** P08514 **Median affinity** 9.43 **Affinity units** pIC50 **Primary target** Yes ### Open Targets mechanisms - **Mechanism** Integrin alpha-IIb/beta-3 inhibitor **Action type** Inhibitor **Target** Integrin alpha-IIb/beta-3 ### DrugCentral mechanisms - **Action type** Inhibitor **Gene symbol** ITGB3|ITGA2B **Protein identifier** P05106|P08514 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (13) - **Condition** Myocardial Infarction **Highest recorded phase** 3 **Condition identifier** EFO:0000612 **Subject identifier** D009203 - **Condition** Stroke **Highest recorded phase** 2 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** Coronary Disease **Highest recorded phase** 3 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Atherosclerosis **Highest recorded phase** 3 **Condition identifier** EFO:0003914 **Subject identifier** D050197 - **Condition** Venous Thromboembolism **Highest recorded phase** 2 **Condition identifier** EFO:0004286 **Subject identifier** D054556 - **Condition** Acute Coronary Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0005672 **Subject identifier** D054058 - **Condition** Pneumonia, Viral **Highest recorded phase** 2 **Condition identifier** EFO:0007541 **Subject identifier** D011024 - **Condition** Myocardial Infarction **Highest recorded phase** 3 **Condition identifier** EFO:0008583 **Subject identifier** D009203 - **Condition** Respiratory Insufficiency **Highest recorded phase** 2 **Condition identifier** EFO:0009686 **Subject identifier** D012131 - **Condition** Renal Insufficiency **Highest recorded phase** 1 **Condition identifier** HP:0000083 **Subject identifier** D051437 - **Condition** Ischemic Stroke **Highest recorded phase** 2 **Condition identifier** HP:0002140 **Subject identifier** D000083242 - **Condition** Thrombosis **Highest recorded phase** 4 **Condition identifier** HP:0004419 **Subject identifier** D013927 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 2 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (19) - **Condition identifier** EFO\_0000612 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000712 - **Condition identifier** EFO\_0001645 **Highest recorded phase** 3 - **Condition identifier** EFO\_0005672 - **Condition identifier** EFO\_0008583 **Highest recorded phase** 3 - **Condition identifier** HP\_0000083 **Highest recorded phase** 1 - **Condition identifier** HP\_0001297 **Highest recorded phase** 3 - **Condition identifier** HP\_0002140 **Highest recorded phase** 3 - **Condition identifier** HP\_0004419 - **Condition identifier** HP\_0004419 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0001106 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004781 - **Condition identifier** MONDO\_0005010 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005068 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005098 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005098 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005099 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005542 **Highest recorded phase** 4 - **Condition identifier** MONDO\_1060198 **Highest recorded phase** 3 ### Reported adverse events (85) - **Event** abdominal discomfort **Reports** 1 **Reporting signal score** 8.2813 - **Event** abdominal pain **Reports** 5 **Reporting signal score** 12.8396 - **Event** abdominal pain upper **Reports** 1 **Reporting signal score** 12.1071 - **Event** acute kidney injury **Reports** 1 **Reporting signal score** 14.6134 - **Event** acute myocardial infarction **Reports** 14 **Reporting signal score** 7.77274 - **Event** angina pectoris **Reports** 129 **Reporting signal score** 335.801 - **Event** anxiety **Reports** 1 **Reporting signal score** 15.718 - **Event** arrhythmia **Reports** 28 **Reporting signal score** 29.0962 - **Event** asthenia **Reports** 1 **Reporting signal score** 30.4318 - **Event** atrial fibrillation **Reports** 1 **Reporting signal score** 7.52315 - **Event** back pain **Reports** 3 **Reporting signal score** 11.2835 - **Event** blood pressure increased **Reports** 1 **Reporting signal score** 8.46476 - **Event** capsular warning syndrome **Reports** 4 **Reporting signal score** 26.1662 - **Event** cardiac failure **Reports** 62 **Reporting signal score** 79.5914 - **Event** cardiac failure acute **Reports** 11 **Reporting signal score** 20.6309 - **Event** cerebral haemorrhage **Reports** 86 **Reporting signal score** 211.949 - **Event** condition aggravated **Reports** 1 **Reporting signal score** 24.4328 - **Event** coronary artery restenosis **Reports** 4 **Reporting signal score** 9.49702 - **Event** coronary artery stenosis **Reports** 10 **Reporting signal score** 15.4602 - **Event** coronary revascularisation **Reports** 18 **Reporting signal score** 104.379 - **Event** device embolisation **Reports** 4 **Reporting signal score** 15.8812 - **Event** diarrhoea **Reports** 3 **Reporting signal score** 51.0923 - **Event** dizziness **Reports** 3 **Reporting signal score** 35.7149 - **Event** drug hypersensitivity **Reports** 5 **Reporting signal score** 16.2231 - **Event** drug interaction **Reports** 7 **Reporting signal score** 8.61224 And 60 more, listed on the interactive page. ### Trial references (15) - NCT00251576 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00251576) - NCT01660373 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01660373) - NCT01109134 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01109134) - NCT01336348 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01336348) - NCT01598337 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01598337) - NCT03078257 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03078257) - NCT01766154 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01766154) - NCT03357133 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03357133) - NCT04818944 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04818944) - NCT04851457 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04851457) - NCT05188417 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05188417) - NCT04368377 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04368377) - NCT04491695 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04491695) - NCT05728333 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05728333) - NCT06037889 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06037889) ## Dosing **Dose** 25 mcg/kg **Route** Intravenous **How often** Up to 18 hours ### Conditions of use (2) - Administer within 5 minutes - Use premixed bag for bolus and infusion ## Chemical properties **Hydrogen bond acceptors** 5 **Hydrogen bond donors** 3 **Polar surface area** 104.73 **Calculated partition coefficient (ALogP)** 2.95 **Calculated partition coefficient (XLogP)** 1.4 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 14 **Heavy atoms** 30 **Molecular formula** C22H36N2O5S **Monoisotopic mass** 440.23449343 **Natural product** Yes ## Evidence counts **Recorded assays** 316 **Active assays** 81 ### Active assay types - Confirmatory ## Pharmacologic actions - Fibrinolytic Agents Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D005343.html) - Platelet Aggregation Inhibitors Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D010975.html) ## Related records ### Trials (55) - A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke - [A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-tirofiban-in-c254d195-740e-4995-b772-aa41764b6a70.md) - Aggrastat Truncated Length Against Standard Therapies in Percutaneous Coronary Intervention - Antiplatelet Effects of Tirofiban vs. Cangrelor N-STEMI Patients Undergoing Percutaneous Coronary Intervention - ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion - BivaliRudin in Acute Myocardial Infarction vs Glycoprotein IIb/IIIa and Heparin :a Randomised Controlled Trial. - Comparison of Antiplatelet Effect of Ticagrelor vs Tirofiban in Patients With Non-ST Elevation Acute Coronary Syndrome - Comparison of Two Treatment Strategies in Patients With an Acute Coronary Syndrome Without ST Elevation - Early Initiation of Low Dose Tirofiban for PPCI in STEMI Patients. - Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke - Effect of Upstream High Bolus Dose of Tirofiban in Primary PCI for the Patients With STEMI on Short Term Outcome - Effects of Intracoronary Prourokinase on the Coronary Flow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction - Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease - Efficacy and Safety of Tirofiban for Patients With BAD (BRANT) - Endovascular Therapy Combined With Tirofiban for Intracranial Atherosclerotic Acute Ischemic Stroke - Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19 - Facilitation Through Aggrastat By drOpping or Shortening Infusion Line in Patients With ST-segment Elevation Myocardial Infarction Compared to or on Top of PRasugrel Loading dOse - FATA: Randomized Study on Facilitated Angioplasty With Tirofiban or Abciximab - GPIIbIIIa Inhibitors in the RESCUe and RESURCOR Networks at the Acute Myocardial Infarction - HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN) ### Approved for (1) - [Thrombotic disease](https://trialight.com/data/condition/thrombotic-disease-3f54ef10-d2ed-524f-a020-8ecb2eb62a52.md) ### In development for (13) - [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 3 - [Acute myocardial infarction](https://trialight.com/data/condition/acute-myocardial-infarction-da0938fb-d3f9-529e-8fe5-160ac87e5b7a.md) Phase 3 - [Atherosclerosis](https://trialight.com/data/condition/atherosclerosis-5dab64e9-1fd4-5dd2-90c2-ce84935652d1.md) Phase 3 - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Ischemic stroke](https://trialight.com/data/condition/ischemic-stroke-22957443-39c1-55ea-8c6d-d5be07d42dc0.md) Phase 2 - Kidney failure Phase 1 - [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) Phase 3 - [Respiratory failure](https://trialight.com/data/condition/respiratory-failure-13d5ac9c-3a96-5ae5-b4c2-ed6861c88d6e.md) Phase 2 - [Stroke disorder](https://trialight.com/data/condition/stroke-disorder-f6ef16d6-34dc-5c87-b764-37f0b5b8d504.md) Phase 2 - Subarachnoid hemorrhage Phase 1 - [Venous thromboembolism](https://trialight.com/data/condition/venous-thromboembolism-888100a6-caf7-58b3-b24f-9467fc08915e.md) Phase 2 - [Viral pneumonia](https://trialight.com/data/condition/viral-pneumonia-7346fe93-f495-5acc-984c-892317879146.md) Phase 2 ### Targets (2) - [ITGA2B](https://trialight.com/data/target/itga2b-2b08bd62-aa66-51b5-af80-a8e0e66c7ac3.md) Integrin alpha-IIb/beta-3 inhibitor - [ITGB3](https://trialight.com/data/target/itgb3-8d05de84-876f-5d95-b273-23919b11b6a3.md) Integrin alpha-IIb/beta-3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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