> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/tiragolumab-3daad510-236f-43c5-87fb-0c3e5df79695
> Record changed: 2026-10-13

# Tiragolumab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298050)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298050)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298050)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298050)

**Drug name**

Tiragolumab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298050)

### Other names (26)

- atezolizumab tiragolumab
- mtig 7192a
- Mtig 7192a
- MTIG-7192A
- mtig7192a
- Mtig7192a
- MTIG7192A
- rg 6058
- RG-6058
- rg6058
- RG6058
- ro 7092284
- RO-7092284
- ro7092284
- RO7092284
- tiragolumab
- Tiragolumab
- tiragolumab \[INN\]
- TIRAGOLUMAB \[JAN\]
- TIRAGOLUMAB \[USAN\]
- Tiragolumab \[WHO-DD\]
- Tiragolumab 600 mg IV
- tiragolumab inn
- tiragolumab jan
- tiragolumab usan

And 1 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1918185-84-8

**ChEMBL ID**

CHEMBL4298050

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298050)

**FDA ingredient codes (UNII)**

- 6XG22YQM2Z

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
T-cell immunoreceptor with Ig and ITIM domains inhibitor

**Action type**  
Inhibitor

**Target**  
T-cell immunoreceptor with Ig and ITIM domains

**Protein identifier**  
Q495A1

### Open Targets mechanisms

- **Mechanism**  
T-cell immunoreceptor with Ig and ITIM domains inhibitor

**Action type**  
Inhibitor

**Target**  
T-cell immunoreceptor with Ig and ITIM domains

### Investigated indications (21)

- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000503

**Subject identifier**  
D013274
- **Condition**  
Glioblastoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Melanoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0002916

**Subject identifier**  
D004938
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Triple Negative Breast Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005537

**Subject identifier**  
D064726
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005708

**Subject identifier**  
D002292
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005922

**Subject identifier**  
D004938
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Rectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000657

**Subject identifier**  
D012004
- **Condition**  
Liver Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002691

**Subject identifier**  
D008113
- **Condition**  
Uterine Cervical Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002974

**Subject identifier**  
D002583
- **Condition**  
Adenocarcinoma

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0003219

**Subject identifier**  
D000230
- **Condition**  
Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Esophageal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0007576

**Subject identifier**  
D004938
- **Condition**  
Endometrial Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0011962

**Subject identifier**  
D016889

### Open Targets indications (40)

- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000702

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003863

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005922

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002038

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004950

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004958

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004970

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004986

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005008

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005086

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005096

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005097

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005494

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005549

**Highest recorded phase**  
2

And 15 more, listed on the interactive page.

### Trial references (43)

- NCT02794571  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02794571)
- NCT05661578  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05661578)
- NCT05715281  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05715281)
- NCT06003621  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06003621)
- NCT06331598  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06331598)
- NCT03281369  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03281369)
- NCT05251948  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05251948)
- NCT03337698  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03337698)
- NCT03563716  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03563716)
- NCT03977467  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03977467)
- NCT04294810  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04294810)
- NCT04619797  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04619797)
- NCT04832854  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04832854)
- NCT05034055  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05034055)
- NCT05746481  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05746481)
- NCT05798663  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05798663)
- NCT05825625  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05825625)
- NCT06267001  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06267001)
- NCT03554083  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03554083)
- NCT05060003  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05060003)
- NCT05116202  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05116202)
- NCT03869190  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03869190)
- NCT04256421  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04256421)
- NCT04308785  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04308785)
- NCT04665856  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04665856)

And 18 more, listed on the interactive page.

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-306 $ Asn-306''''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-306 $ Asn-306''
- **Component**  
Disulfide bridge location

**Sequence**  
22-99 $ 22''-99'' $ 23'-94' $ 23'''-94''' $ 140'-200' $ 140'''-200''' $ 153-209 $ 153''-209'' $ 220'-229 $ 220'''-229'' $ 235-235'' $ 238-238'' $ 270-330 $ 270''-330'' $ 376-434 $ 376''-434''

## Related records

### Trials (63)

- A Phase 2 Clinical Trial Evaluating the Efficacy and Safety of Dual Immune Checkpoint Inhibition With Anti-PD-L1 (Atezolizumab) and Anti-TIGIT (Tiragolumab) in Cancer of Unknown Primary
- A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
- A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)
- A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer
- A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)
- A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response
- A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)
- A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma)
- A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma
- A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer
- [A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-targeted-dd62fe2e-2b36-4ddc-82bc-7f1549d780cc.md)
- A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors with Resectable Disease with Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H)
- A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)
- A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer
- A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck
- A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma
- A Study of Atezolizumab With or Without Tiragolumab Consolidation in Limited Stage Small Cell Lung Cancer
- A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer
- A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy
- A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

### In development for (21)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3
- Carcinoma of esophagus Phase 3
- [Cervical cancer](https://trialight.com/data/condition/cervical-cancer-10fb8f6c-5aac-5281-8f06-7238adeec443.md) Phase 2
- [Endometrial cancer](https://trialight.com/data/condition/endometrial-cancer-4da2a0bc-7943-502b-a698-cc2beccbed8c.md) Phase 1
- [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 3
- [Esophageal squamous cell carcinoma](https://trialight.com/data/condition/esophageal-squamous-cell-carcinoma-c10bd9c9-02f9-5805-8008-b021f4604e7a.md) Phase 3
- [Gastric adenocarcinoma](https://trialight.com/data/condition/gastric-adenocarcinoma-6bb74a55-7ba6-53e3-a113-22296a84d6ae.md) Phase 1
- [Gastroesophageal junction adenocarcinoma](https://trialight.com/data/condition/gastroesophageal-junction-adenocarcinoma-de7e280e-cbd1-5266-a5dd-dda00261a706.md) Phase 1
- Glioblastoma Phase 2
- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 2
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 3
- Liver cancer Phase 1
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 2
- Neoplasm Phase 3
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3
- Rectal cancer Phase 2
- Renal cell adenocarcinoma Phase 2
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 3
- [Triple-negative breast carcinoma](https://trialight.com/data/condition/triple-negative-breast-carcinoma-059174a2-9b5f-5234-90b9-4a4fee6eb9bb.md) Phase 1

### Targets (1)

- [TIGIT](https://trialight.com/data/target/tigit-3420020b-537a-54b3-8cbf-76103a59da64.md) T-cell immunoreceptor with Ig and ITIM domains inhibitor

---

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