> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/timolol-maleate-d3b5d7ee-d8f2-4ddd-9168-1f49a7b9f34b
> Record changed: 2026-10-13

# Timolol maleate

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

First approval year

1978

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

## Development status

**First approval year**

1978

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

**Drug name**

Timolol maleate

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

**Molecular weight**

432.5

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

**Structure (SMILES)**

CC(C)(C)NC\[C@H\](O)COc1nsnc1N1CCOCC1.O=C(O)/C=C\\C(=O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

### Brand names (23)

- blocadren
- Blocadren
- istalol
- Istalol
- timolol maleate
- Timolol maleate
- timolol maleate component of combigan
- Timolol maleate component of combigan
- timolol maleate component of cosopt
- Timolol maleate component of cosopt
- timolol maleate component of duotrav
- Timolol maleate component of duotrav
- timolol maleate component of ganfort
- Timolol maleate component of ganfort
- timolol maleate component of xalacom
- Timolol maleate component of xalacom
- timoptic
- Timoptic
- timoptic in ocudose
- Timoptic in ocudose
- timoptic xe
- Timoptic xe
- Timoptic-xe

### Other names (63)

- (-)-1-(TERT-BUTYLAMINO)-3-((4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)OXY)-2-PROPANOL MALEATE (1:1) (SALT)
- 1 tert butylamino 3 4 morpholino 1 2 5 thiadiazol 3 yl oxy 2 propanol maleate 1 1 salt
- 2 propanol 1 1 1 dimethylethyl amino 3 4 4 morpholinyl 1 2 5 thiadiazol 3 yl oxy s z 2 butenedioate 1 1 salt
- 2-PROPANOL, 1-((1,1-DIMETHYLETHYL)AMINO)-3-((4-(4-MORPHOLINYL)-1,2,5-THIADIAZOL-3-YL)OXY)-, (S)-, (Z)-2-BUTENEDIOATE (1:1) (SALT)
- aquanil
- Aquanil
- combigan component timolol maleate
- COMBIGAN COMPONENT TIMOLOL MALEATE
- cosopt component timolol maleate
- COSOPT COMPONENT TIMOLOL MALEATE
- duotrav component timolol maleate
- DUOTRAV COMPONENT TIMOLOL MALEATE
- ganfort component timolol maleate
- GANFORT COMPONENT TIMOLOL MALEATE
- nsc 757351
- NSC-757351
- ophtamolol
- Ophtamolol
- Timolol (as maleate)
- timolol 0 5 ophthalmic solution timoptic
- Timolol 0.5% Ophthalmic Solution (Timoptic)
- timolol as maleate
- timolol hydrogen maleate salt
- Timolol hydrogen maleate salt
- TIMOLOL HYDROGEN MALEATE SALT \[MI\]

And 38 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 26921-17-5

**ChEMBL ID**

CHEMBL1200870

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

**InChIKey**

WLRMANUAADYWEA-NWASOUNVSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200870)

**FDA ingredient codes (UNII)**

- P8Y54F701R

### ATC classification codes (2)

- C07AA06
- S01ED01

Sources for recorded values

Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=10600)

### PubChem compound IDs (2)

- 5281056
- 139196155

### RxNorm IDs (RxCUI) (2)

- 10600
- 42933

## Regulatory information

### United States

**Applicant**

BAUSCH AND LOMB INC

**Approval date**

17 Aug 1978

**Application number**

NDA018086

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Drug name stem**

\-olol

#### Administration routes

- Oral
- topical

### Mechanisms of action (2)

- **Mechanism**  
Beta-1 adrenergic receptor antagonist

**Action type**  
Antagonist

**Target**  
Beta-1 adrenergic receptor

**Protein identifier**  
P08588
- **Mechanism**  
Beta-2 adrenergic receptor antagonist

**Action type**  
Antagonist

**Target**  
Beta-2 adrenergic receptor

**Protein identifier**  
P07550

### Open Targets mechanisms (2)

- **Mechanism**  
Beta-1 adrenergic receptor antagonist

**Action type**  
Antagonist

**Target**  
Beta-1 adrenergic receptor
- **Mechanism**  
Beta-2 adrenergic receptor antagonist

**Action type**  
Antagonist

**Target**  
Beta-2 adrenergic receptor

### Investigated indications (8)

- **Condition**  
Hypertension, Portal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000666

**Subject identifier**  
D006975
- **Condition**  
Glaucoma, Open-Angle

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0004190

**Subject identifier**  
D005902
- **Condition**  
Hemangioma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000635

**Subject identifier**  
D006391
- **Condition**  
Optic Neuropathy, Ischemic

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1000809

**Subject identifier**  
D018917
- **Condition**  
Corneal Edema

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000879

**Subject identifier**  
D015715
- **Condition**  
Low Tension Glaucoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001022

**Subject identifier**  
D057066
- **Condition**  
Ocular Hypertension

**Highest recorded phase**  
4

**Condition identifier**  
EFO:1001069

**Subject identifier**  
D009798
- **Condition**  
Glaucoma

**Highest recorded phase**  
4

**Condition identifier**  
MONDO:0005041

**Subject identifier**  
D005901

### Open Targets indications (21)

- **Condition identifier**  
EFO\_0004190
- **Condition identifier**  
EFO\_1000635

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000809

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1000879

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001022

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001069
- **Condition identifier**  
HP\_0001009

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002407
- **Condition identifier**  
MONDO\_0002407

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005041
- **Condition identifier**  
MONDO\_0005041

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005338

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005898
- **Condition identifier**  
MONDO\_0006500

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006712

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006837

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006875

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0019180
- **Condition identifier**  
MONDO\_0019180

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0024291

**Highest recorded phase**  
1
- **Condition identifier**  
Orphanet\_98671

**Highest recorded phase**  
1

### Reported adverse events (57)

- **Event**  
abnormal sensation in eye

**Reports**  
11

**Reporting signal score**

26.3077
- **Event**  
anaemia

**Reports**  
2

**Reporting signal score**

26.4884
- **Event**  
anterior chamber disorder

**Reports**  
8

**Reporting signal score**

31.7936
- **Event**  
blepharitis

**Reports**  
19

**Reporting signal score**

52.1433
- **Event**  
blindness

**Reports**  
30

**Reporting signal score**

32.7553
- **Event**  
bradycardia

**Reports**  
104

**Reporting signal score**

130.088
- **Event**  
cataract

**Reports**  
37

**Reporting signal score**

38.8159
- **Event**  
choroidal detachment

**Reports**  
13

**Reporting signal score**

45.7763
- **Event**  
choroidal effusion

**Reports**  
9

**Reporting signal score**

26.3125
- **Event**  
conjunctivitis

**Reports**  
25

**Reporting signal score**

34.1482
- **Event**  
conjunctivitis allergic

**Reports**  
10

**Reporting signal score**

29.7475
- **Event**  
corneal deposits

**Reports**  
24

**Reporting signal score**

97.9111
- **Event**  
corneal oedema

**Reports**  
25

**Reporting signal score**

72.7574
- **Event**  
diarrhoea

**Reports**  
10

**Reporting signal score**

50.3491
- **Event**  
dry eye

**Reports**  
33

**Reporting signal score**

44.3187
- **Event**  
erythema of eyelid

**Reports**  
18

**Reporting signal score**

46.4502
- **Event**  
eye burns

**Reports**  
10

**Reporting signal score**

40.3283
- **Event**  
eye discharge

**Reports**  
42

**Reporting signal score**

122.112
- **Event**  
eye disorder

**Reports**  
31

**Reporting signal score**

46.0135
- **Event**  
eye inflammation

**Reports**  
17

**Reporting signal score**

32.9378
- **Event**  
eye irritation

**Reports**  
230

**Reporting signal score**

754.476
- **Event**  
eye pain

**Reports**  
138

**Reporting signal score**

353.682
- **Event**  
eye pruritus

**Reports**  
82

**Reporting signal score**

211.129
- **Event**  
eye swelling

**Reports**  
58

**Reporting signal score**

107.751
- **Event**  
eyelid disorder

**Reports**  
12

**Reporting signal score**

34.8227

And 32 more, listed on the interactive page.

### Trial references (24)

- NCT00006398  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00006398)
- NCT00108017  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00108017)
- NCT00293787  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00293787)
- NCT00311389  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00311389)
- NCT00753168  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00753168)
- NCT01279083  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01279083)
- NCT00449956  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00449956)
- NCT00519753  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00519753)
- NCT00811850  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00811850)
- NCT01336569  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01336569)
- NCT01514721  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01514721)
- NCT01514734  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01514734)
- NCT01518244  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01518244)
- NCT01845038  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01845038)
- NCT02697318  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02697318)
- NCT02852057  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02852057)
- NCT00273455  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00273455)
- NCT02754596  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02754596)
- NCT00800423  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00800423)
- NCT01607671  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01607671)
- NCT01685398  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01685398)
- NCT02145884  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02145884)
- NCT02913612  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02913612)
- NCT04857827  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04857827)

## Dosing

**Dose**

1 drop

**Route**

Topical

**How often**

Twice daily

### Conditions of use

- Instill at least 5 minutes apart if using multiple drops

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

2

**Polar surface area**

79.74

**Calculated partition coefficient (ALogP)**

0.5

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

29

**Molecular formula**

C17H28N4O7S

**Monoisotopic mass**

432.16787042

**Natural product**

No

## National Drug Codes

- 0023-9211
- 0378-0221
- 0781-7186
- 0832-1425
- 14445-405
- 16571-223
- 16571-224
- 16571-225
- 24208-004
- 24208-486
- 24208-498
- 24208-499
- 24208-812
- 24208-813
- 24208-814
- 24208-816
- 25021-008
- 25021-009
- 42571-147
- 42571-382
- 42571-398
- 42571-403
- 42571-404
- 43598-747
- 43598-748

And 89 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

1,831

**Active assays**

6

### Active assay types (2)

- Confirmatory
- Screening

## Pharmacologic actions

- Adrenergic beta-Antagonists  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000319.html)
- Anti-Arrhythmia Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000889.html)
- Antihypertensive Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000959.html)

## Related records

### Trials (232)

- 24-hour Control of Intraocular Pressure (IOP) in Ocular Hypertension
- 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy
- 24-hour Efficacy and Tolerability of the Tafluprost-timolol Fixed Association Without Preservatives in Glaucomatous or Ocular Hypertensive Patients Already Treated With Latanoprost Preserved With BAK. A Prospective, Open Study of 3 Months Duration.
- 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients
- 24-hour Intraocular Pressure (IOP) Control With the Bimatoprost/Timolol Fixed Combination
- 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination
- 24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice
- 24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost
- 24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol
- 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations
- 24-hr Intraocular Pressure Control With Dorzolamide/Timolol vs the Brimonidine/Timolol Fixed Combination
- 24-hr IOP With Travoprost/Timolol Compared With Latanoprost/Timolol in XFG
- A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension
- A 12-week, Randomized, Double-masked, Parallel Group Comparison of Evening Dosing With Xalacom in Subjects With Glaucoma
- A 12-Week, Randomized, Double-Masked, Parallel Group Comparison Of Evening Dosing With Xalacom In Subjects With Glaucoma
- A 6 Month Study Comparing Latanoprost With Timolol in Patients With Open Angle Glaucoma or Ocular Hypertension
- A 6-Week Safety and Efficacy Study of Travatan Compared to Xalcom in Subjects With Open-Angle Glaucoma(OAG) or Ocular Hypertension(OHT)
- A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn
- A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs
- A Comparison of the Effect of Dorzolamide and Timolol on Optic Disk Blood Flow in Patients With Open Angle Glaucoma

### Approved for (3)

- [Glaucoma](https://trialight.com/data/condition/glaucoma-7a3c05c0-9871-55db-af74-962761181784.md)
- [Ocular hypertension](https://trialight.com/data/condition/ocular-hypertension-754666dc-b494-5a18-a3ee-6a2d941c65dd.md)
- [Open-angle glaucoma](https://trialight.com/data/condition/open-angle-glaucoma-fb887921-4122-599b-b8a0-928b40ddc7a2.md)

### In development for (5)

- Anterior ischemic optic neuropathy Phase 1
- Corneal edema Phase 3
- Hemangioma Phase 3
- Low tension glaucoma Phase 2
- Portal hypertension Phase 3

### Other linked conditions (2)

- Capillary hemangioma
- Hereditary hemorrhagic telangiectasia

### Targets (2)

- [ADRB1](https://trialight.com/data/target/adrb1-6e315eb7-4a1a-5347-bacb-acfe97cbc2b5.md) Beta-1 adrenergic receptor antagonist
- [ADRB2](https://trialight.com/data/target/adrb2-dd50b672-19f0-5015-be62-c6f5861dc510.md) Beta-2 adrenergic receptor antagonist

---

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