> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tilrekimig-4e01bc49-f30a-471c-8495-4a409c5c20bc > Record changed: 2026-10-13 # Tilrekimig Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068474) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068474) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068474) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068474) **Drug name** Tilrekimig Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068474) ### Other names (13) - immunoglobulin anti human macaca fascicularis interleukin 13 human mus musculus monoclonal pf 07296735 κ chain fusion protein with peptide linker ggggs fusion protein with immunoglobulin g1 448 glutamic acid 461 alanine 462 alanine 464 alanine 595 glutamic acid 655 leucine 661 serine anti human macaca fascicularis interleukin 4 human monoclonal pf 07296735 γ1 chain cys453 cys231 cys456 cys234 bis disulfide with immunoglobulin g1 226 arginine 239 alanine 240 alanine 242 alanine 414 arginine 433 leucine 439 serine anti human macaca fascicularis thymic stromal lymphopoietin human monoclonal pf 07296734 γ1 chain cys218 cys 221 disulfide with immunoglobulin anti human macaca fascicularis interleukin 13 recombinant heavy chain variable constant domain 1 fusion protein with peptide linker epksc cys447 cys218 disulfide with immunoglobulin anti human macaca fascicularis interleukin 4 human mus musculus monoclonal pf 07296735 κ chain cys225 cys213 disulfide with immunoglobulin anti human macaca fascicularis thymic stromal lymphopoietin human monoclonal pf 07296734 λ chain - Immunoglobulin, anti-(human/Macaca fascicularis interleukin 13) (human-Mus musculus monoclonal PF-07296735 κ-chain) fusion protein with peptide linker (GGGGS) fusion protein with immunoglobulin G1 \[448-glutamic acid,461-alanine,462-alanine,464-alanine,595-glutamic acid,655-leucine,661-serine\] anti-(human/Macaca fascicularis interleukin 4) (human monoclonal PF-07296735 γ1-chain), (Cys453→Cys231′),(Cys456→Cys234′)-bis(disulfide) with immunoglobulin G1 \[226-arginine,239-alanine,240-alanine,242-alanine,414-arginine,433-leucine,439-serine\] anti-(human/Macaca fascicularis thymic stromal lymphopoietin) (human monoclonal PF-07296734 γ1-chain), (Cys218→Cys-221")-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 13) (recombinant heavy chain variable-constant domain 1) fusion protein with peptide linker (EPKSC), (Cys447→Cys218′′′)-disulfide with immunoglobulin anti-(human/Macaca fascicularis interleukin 4) (human-Mus musculus monoclonal PF-07296735 κ-chain), (Cys225′→Cys213′′′′)-disulfide with immunoglobulin anti-(human/Macaca fascicularis thymic stromal lymphopoietin) (human monoclonal PF-07296734 λ-chain) - pf 07275315 - Pf-07275315 - PF-07275315 - tilrekimig - Tilrekimig - tilrekimig \[INN\] - TILREKIMIG \[USAN\] - Tilrekimig \[WHO-DD\] - tilrekimig inn - tilrekimig usan - tilrekimig who dd ## Identifiers **CAS registry numbers** - 2981469-90-1 **ChEMBL ID** CHEMBL6068474 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068474) **FDA ingredient codes (UNII)** - LD48NPB5QS ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-mig ### Investigated indications (3) - **Condition** Dermatitis, Atopic **Highest recorded phase** 2 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Dermatitis **Highest recorded phase** 1 **Condition identifier** HP:0011123 **Subject identifier** D003872 - **Condition** Inflammation **Highest recorded phase** 1 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (6) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** HP\_0011123 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005002 **Highest recorded phase** 2 - **Condition identifier** MP\_0001845 ### Trial references - NCT05995964 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05995964) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (6) - **Component** DualFab Anti-IL-4 LC; (L'') **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRASQSVDEEGDSYMNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNKDPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** DualFab Anti-IL-13 mFd; (M') **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVASISSGDTTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARNEGYYFGLTLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS - **Component** Glycosylation sites (N) **Sequence** 524 $ 302'' - **Component** Disulfide bridges **Sequence** 22'-95' $ 22'''-96''' $ 22''''-87'''' $ 23-92 $ 23''-92'' $ 136''''-195'''' $ 136''''-195'''' $ 138-198 $ 138''-198'' $ 138''-198'' $ 145'-201' $ 149'''-205''' $ 218-221' $ 225'''-213'''' $ 245-320 $ 266'''-326''' $ 371-427'' $ 372'''-430'' $ 447-218'' $ 453-231''' $ 456-234''' $ 488-548 $ 594-652 - **Component** Single Fab Anti-TSLPLC; (L'''') **Type** Protein **Sequence** SYVLTQPPSVSVAPGQTARITCGGNNLGSKSVHWYQQKPGQAPVLVVYDDKDRPSWIPERFSGSNSGNTATLTISRGEAGDEADYYCQVWDSKSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS - **Component** Single Fab Anti-TSLP HC; (H''') **Type** Protein **Sequence** QMQLVESGGGVVQPGRSLRLSCAASGFTFRTYGMHWVRQAPGKGLEWVAVIWYDGSNKHYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARAPQWYLVHEAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCRKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK ## Related records ### Trials (9) - A Study to Learn About the Single Dose Pharmacokinetics of Study Medicine Called Tilrekimig in Healthy Adults When Co-Mixed With rHuPH20 - [A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease](https://trialight.com/data/trial/a-study-to-learn-about-the-study-medicine-called-pf-07275315-66c3d90b-a913-4b00-a06a-61216c024228.md) - A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma - [A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to Severe Eczema](https://trialight.com/data/trial/a-study-to-learn-about-the-study-medicine-called-tilrekimig-46410b5b-7208-44ff-ac15-b19efe962432.md) - A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to-Severe Eczema - [A Study to Learn About the Study Medicine Called Tilrekimig in People With Severe Asthma](https://trialight.com/data/trial/a-study-to-learn-about-the-study-medicine-called-tilrekimig-246d4af0-5308-43fd-a3cb-69d42317cf58.md) - [A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis](https://trialight.com/data/trial/a-study-to-learn-about-two-study-medicines-pf-07275315-and-d318ca7a-09b3-4260-9698-26637c1cbe41.md) - A Study to Learn How the Study Medicine Called PF-07275315 Works in Healthy People - A Study to Learn More About the Study Medicine PF-07275315 in Healthy Chinese Adult Participants ### In development for (3) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Dermatitis](https://trialight.com/data/condition/dermatitis-cf8b2157-f593-5138-bd3d-f2a74343308e.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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