> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/tigulixostat-719392e8-b776-4623-a095-ebc29854c0c3
> Record changed: 2026-10-13

# Tigulixostat

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

**Drug name**

Tigulixostat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

**Molecular weight**

294.31

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

**Structure (SMILES)**

CC(C)n1cc(C#N)c2cc(-n3cc(C(=O)O)cn3)ccc21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

### Other names (16)

- lc 350189
- LC-350189
- lc350189
- Lc350189
- LC350189
- LC350189 200 mg
- LC350189 200mg
- LC350189 600mg
- LC350189 Capsule
- LC350189 Tablet
- tigulixostat
- Tigulixostat
- tigulixostat \[INN\]
- Tigulixostat \[WHO-DD\]
- tigulixostat inn
- tigulixostat who dd

## Identifiers

**CAS registry numbers**

- 1287766-55-5

**ChEMBL ID**

CHEMBL3652780

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

**InChIKey**

JLQQRYOWGCIMMZ-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3652780)

**PubChem compound IDs**

- 51039100

**FDA ingredient codes (UNII)**

- WZ0PYQ6VLU

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-stat

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0004274

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0009104

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005393

**Highest recorded phase**  
3

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

1

**Polar surface area**

83.84

**Calculated partition coefficient (ALogP)**

2.98

**Calculated partition coefficient (XLogP)**

1.9

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

22

**Molecular formula**

C16H14N4O2

**Monoisotopic mass**

294.11167570

**Natural product**

No

## Evidence counts

**Recorded assays**

2

**Active assays**

2

### Active assay types

- Confirmatory

## Related records

### Trials (10)

- A Study to Assess Efficay and Safety of LC350189 Different Doses in Gout Patients With Hyperuricemia
- Effect of Tigulixostat on the Pharmacokinetics of Theophylline
- Mass Balance Study of \[14C\]LC350189 in Healthy Volunteers
- Relative Bioavailability Study to Assess an LC350189 Tablet Compared to an LC350189 Capsule in Healthy Adults
- Renal PK Study of LC350189
- Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of LC350189
- Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
- Tigulixostat (IBI128) vs Febuxostat in Gout
- [Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients](https://trialight.com/data/trial/tigulixostat-phase-3-study-allopurinol-controlled-in-gout-5cb36ece-3526-4d52-afbb-7a331d83d7d0.md)
- Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients

### In development for (1)

- [Gout](https://trialight.com/data/condition/gout-b61aaf55-4a3b-56d9-966a-ca77100d2fc5.md) Phase 1

---

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