> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/tenofovir-04880c9f-8326-44eb-a4f7-c237290edcf7 > Record changed: 2026-11-04 # Tenofovir Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) **Drug name** Tenofovir Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) **Molecular weight** 305.23 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) **Structure (SMILES)** C\[C@H\](Cn1cnc2c(N)ncnc21)OCP(=O)(O)O.O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) ### Other names (24) - \[\[(R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy\]methyl\]phosphonic acid, monohydrate - gs 1278 - GS-1278 - pmp a - PMP-A - pmpa - PMPA - r 2 6 amino 9h purin 9 yl 1 methylethoxy methyl phosphonic acid monohydrate - tenofovir - Tenofovir - TENOFOVIR \[MART.\] - TENOFOVIR \[USAN\] - TENOFOVIR \[USP-RS\] - TENOFOVIR \[VANDF\] - tenofovir hydrate - Tenofovir hydrate - tenofovir mart - tenofovir monohydrate - Tenofovir monohydrate - tenofovir tdf - tenofovir usan - tenofovir usp rs - tenofovir vandf - tenofovir(TDF) ## Identifiers **ChEMBL ID** CHEMBL3989702 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) **InChIKey** PINIEAOMWQJGBW-FYZOBXCZSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3989702) **PubChem compound IDs** - 21146529 **RxNorm IDs (RxCUI)** - 117466 **FDA ingredient codes (UNII)** - 99YXE507IL ### CAS registry numbers (2) - 147127-20-6 - 206184-49-8 ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** tenofovir **Type** Synthetic organic **Drug name stem** \-vir **Approval recorded by Guide to Pharmacology** Yes ### Open Targets mechanisms (2) - **Mechanism** DNA polymerase/reverse transcriptase inhibitor **Action type** Inhibitor **Target** DNA polymerase/reverse transcriptase - **Mechanism** Human immunodeficiency virus type 1 reverse transcriptase inhibitor **Action type** Inhibitor **Target** Human immunodeficiency virus type 1 reverse transcriptase ### Open Targets indications (32) - **Condition identifier** EFO\_0000180 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000764 - **Condition identifier** EFO\_0004197 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004239 **Highest recorded phase** 3 - **Condition identifier** EFO\_0803536 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001248 **Highest recorded phase** 1 - **Condition identifier** HP\_0000093 - **Condition identifier** HP\_0001395 - **Condition identifier** HP\_0003287 - **Condition identifier** HP\_0100578 - **Condition identifier** MONDO\_0002691 - **Condition identifier** MONDO\_0005109 - **Condition identifier** MONDO\_0005109 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005111 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005231 - **Condition identifier** MONDO\_0005249 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005301 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005344 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005366 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006052 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007256 - **Condition identifier** MONDO\_0013209 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0016318 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0016537 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018076 **Highest recorded phase** 3 And 7 more, listed on the interactive page. ### Reported adverse events (39) - **Event** abortion spontaneous **Reports** 615 **Reporting signal score** 818.58 - **Event** acute hiv infection **Reports** 78 **Reporting signal score** 334.45 - **Event** birth mark **Reports** 24 **Reporting signal score** 115.49 - **Event** blood creatinine increased **Reports** 547 **Reporting signal score** 503.945 - **Event** blood hiv rna increased **Reports** 187 **Reporting signal score** 626.502 - **Event** blood phosphorus decreased **Reports** 125 **Reporting signal score** 267.99 - **Event** congenital umbilical hernia **Reports** 29 **Reporting signal score** 131.014 - **Event** csf hiv escape syndrome **Reports** 78 **Reporting signal score** 341.694 - **Event** drug resistance **Reports** 841 **Reporting signal score** 1,763.75 - **Event** fanconi syndrome **Reports** 199 **Reporting signal score** 649.568 - **Event** fanconi syndrome acquired **Reports** 341 **Reporting signal score** 1,254.36 - **Event** genotype drug resistance test positive **Reports** 149 **Reporting signal score** 436.13 - **Event** glycosuria **Reports** 121 **Reporting signal score** 361.019 - **Event** hepatitis b **Reports** 172 **Reporting signal score** 333.283 - **Event** hepatitis b dna increased **Reports** 81 **Reporting signal score** 248.204 - **Event** hypophosphataemia **Reports** 247 **Reporting signal score** 508.995 - **Event** immune reconstitution inflammatory syndrome **Reports** 416 **Reporting signal score** 1,117.88 - **Event** immune reconstitution syndrome **Reports** 113 **Reporting signal score** 324.746 - **Event** lipodystrophy acquired **Reports** 260 **Reporting signal score** 828.964 - **Event** mitochondrial toxicity **Reports** 154 **Reporting signal score** 572.403 - **Event** nephropathy toxic **Reports** 296 **Reporting signal score** 527.83 - **Event** osteomalacia **Reports** 114 **Reporting signal score** 317.683 - **Event** osteoporosis **Reports** 564 **Reporting signal score** 1,136.85 - **Event** pathogen resistance **Reports** 524 **Reporting signal score** 1,381.13 - **Event** portal hypertension **Reports** 29 **Reporting signal score** 76.6502 And 14 more, listed on the interactive page. ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 3 **Polar surface area** 136.38 **Calculated partition coefficient (ALogP)** \-0.05 **Prodrug** Yes **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 20 **Molecular formula** C9H16N5O5P **Monoisotopic mass** 305.08890563 **Natural product** No ## Related records ### Trials (207) - A Drug-Drug Interaction Study Between ATI-2173 and Tenofovir Disoproxil Fumarate in Healthy Subjects - A Feasibility Study to Assess Tenofovir and Maraviroc Protection Against HIV-1 in Cervical and Vaginal Explants - A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Negative, Chronic Hepatitis B Virus (HBV) Infection - A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection - A Multicenter, Open-label, Randomized Clinical Study to Assess Efficacy and Safety of 3 Doses of Myrcludex B for 24 Weeks in Combination With Tenofovir Compared to Tenofovir Alone to Suppress HBV Replication in Patients With Chronic Hepatitis D - A New Tablet Containing Two FDA-Approved Drugs In HIV-Infected Patients Who Have Not Received Prior Therapy - A Phase I Trial to Assess the Safety of Tenofovir Gel and Film Formulations: FAME 04 - A Phase IIIb Study to Compare Entecavir Plus Tenofovir vs. Adefovir Added to Continuing Lamivudine Therapy in Adult Patients With Lamivudine-Resistant Hepatitis B Infection - A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS) Toxicity, to a Fixed Dose Combination of Tenofovir/Emtricitabine/Rilpivirine - A Single-arm Study Evaluating the Efficacy and Safety of Telbivudine With or Without add-on Tenofovir in Adults With HBeAg-positive Chronic Hepatitis B (CHB) - A Study Evaluating the Safety, Pharmacokinetics, and Antiviral Efficacy of SB 9200 in Subjects Infected With Chronic HBV - A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB) - A Study of Early Immunologic Response in Asian Patients With Chronic Hepatitis B, Treated With Pegasys (Peginterferon Alfa-2a (40KD)), Nucleoside Analogues, or Both - A Study of Pegasys (Peginterferon Alfa 2a) Alone or in Combination With Tenofovir in Patients With Chronic Hepatitis D. - A Study of PMPA in HIV-Infected Patients - A Study of Treatment With RO6864018 in Virologically Suppressed Participants With Chronic Hepatitis B Virus (HBV) Infection - A Study to Compare Efficacy and Safety of Tenofovir Used Alone or in Combination With Pegylated Interferon Alpha-2b in Participants With Chronic Hepatitis B and Elevated Alanine Aminotransferase (MK-4031-384) - A Study to Compare Three Different Formulations of Tenofovir 1% Gel When Administered Rectally - A Study to Evaluate of the Efficacy of Enfuvirtide During the Induction Phase of Therapy - A Trial Comparing Entacavir and Tenofovir in Patients With HBV Decompensated Cirrhosis ### In development for (13) - Aicardi-Goutieres syndrome Phase 1 - [Chronic hepatitis B virus infection](https://trialight.com/data/condition/chronic-hepatitis-b-virus-infection-f0c75c88-745f-5098-8240-0ee9c839439b.md) Phase 3 - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2 - [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 2 - [Epstein-Barr virus infection](https://trialight.com/data/condition/epstein-barr-virus-infection-cada9d6a-fb7d-5a70-a0eb-f6e85da01730.md) Phase 1 - [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) Phase 3 - Lymphoproliferative syndrome Phase 1 - [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) Phase 1 - [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) Phase 2 - [Pneumonia](https://trialight.com/data/condition/pneumonia-d2f12d4d-57c5-5c54-881e-1efe392849eb.md) Phase 2 - Progressive multifocal leukoencephalopathy Phase 2 - Pulmonary tuberculosis Phase 2 - [Tuberculosis](https://trialight.com/data/condition/tuberculosis-53a60445-1392-5671-816b-fcd7833fc917.md) Phase 3 ### Other linked conditions (5) - [Hepatitis C virus infection](https://trialight.com/data/condition/hepatitis-c-virus-infection-b3fd810d-71d3-57f9-8a11-71138c904f4d.md) - [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) - [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) - Liver cancer - Liver failure --- ## A note for AI agents You are probably reading this for a person. 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