> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/telratolimod-aad7c32e-d673-4ec9-9ee2-9e2602918ebb
> Record changed: 2026-10-13

# Telratolimod

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

**Drug name**

Telratolimod

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

**Molecular weight**

593.9

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

**Structure (SMILES)**

CCCCCCCCCCCCCCCCCC(=O)NCCCCOn1c(CCCC)nc2c(N)nc3ccccc3c21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

### Other names (14)

- 3m 052
- 3M-052
- medi 9197
- Medi 9197
- Medi-9197
- medi9197
- Medi9197
- MEDI9197
- telratolimod
- Telratolimod
- telratolimod \[INN\]
- Telratolimod \[WHO-DD\]
- telratolimod inn
- telratolimod who dd

## Identifiers

**CAS registry numbers**

- 1359993-59-1

**ChEMBL ID**

CHEMBL4297631

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

**InChIKey**

RRTPWQXEERTRRK-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297631)

**PubChem compound IDs**

- 56833311

**FDA ingredient codes (UNII)**

- 16598XQ2BT

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-imod

### Mechanisms of action (2)

- **Mechanism**  
Toll-like receptor 7 agonist

**Action type**  
Agonist

**Target**  
Toll-like receptor 7

**Protein identifier**  
Q9NYK1
- **Mechanism**  
Toll-like receptor 8 agonist

**Action type**  
Agonist

**Target**  
Toll-like receptor 8

**Protein identifier**  
Q9NR97

### Open Targets mechanisms (2)

- **Mechanism**  
Toll-like receptor 7 agonist

**Action type**  
Agonist

**Target**  
Toll-like receptor 7
- **Mechanism**  
Toll-like receptor 8 agonist

**Action type**  
Agonist

**Target**  
Toll-like receptor 8

### Investigated indications (4)

- **Condition**  
HIV Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000180

**Subject identifier**  
D015658
- **Condition**  
HIV Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000764

**Subject identifier**  
D015658
- **Condition**  
Lymphoma, T-Cell, Cutaneous

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002913

**Subject identifier**  
D016410
- **Condition**  
Zika Virus Infection

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0018661

**Subject identifier**  
D000071243

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0000180

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0000607

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1

### Trial references (8)

- NCT02556463  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02556463)
- NCT04177355  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04177355)
- NCT05781542  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05781542)
- NCT05903339  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05903339)
- NCT05983874  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05983874)
- NCT06267872  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06267872)
- NCT05828095  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05828095)
- NCT06334393  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06334393)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

2

**Polar surface area**

95.06

**Calculated partition coefficient (ALogP)**

9.1

**Calculated partition coefficient (XLogP)**

11.9

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

25

**Heavy atoms**

43

**Molecular formula**

C36H59N5O2

**Monoisotopic mass**

593.46687614

**Natural product**

No

## Evidence counts

**Recorded assays**

4

**Active assays**

0

## Pharmacologic actions

- Adjuvants, Immunologic  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000276.html)

## Related records

### Trials (13)

- A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum
- A Clinical Trial to Evaluate the Safety and Immunogenicity of a Prophylactic HIV Vaccine Candidate
- A Clinical Trial to Evaluate the Safety and Immunogenicity of Glycan-trimmed HIV-1 Nanoparticle Vaccine (UVAX-1107), Followed by Homologous or Wild-type HIV-1 Nanoparticle Vaccine (UVAX-1197) Boost, Each Adjuvanted With 3M-052-AF + Alum in Adult Participants Without HIV
- A Study of MEDI9197 in Subjects With Solid Tumors or CTCL and in Combination With Durvalumab and/or Palliative Radiation in Subjects With Solid Tumors
- A Study to Evaluate the Safety and Immunogenicity of 2 Doses of 100µg BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, Given to a Population of Adults Who Have Received 3 Doses of 300µg BG505 SOSIP.GT1.1 gp140 Vaccine, Adjuvanted
- Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health
- Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like HIV-1 Envelope Trimer in Adults Without HIV
- Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding NP-GT8 and IL-12, With or Without a TLR-agonist-Adjuvanted HIV Env Trimer 4571 Boost, in Adults Without HIV
- Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants in Healthy, HIV-uninfected Adults
- Pancoronavirus Vaccine Study in Healthy Adults
- [Phase 1 Trial to Assess the Safety and Immunogenicity of an Inactivated, Adjuvanted Whole Zika Virus Vaccine Candidate (VLA1601) in Healthy Adults](https://trialight.com/data/trial/phase-1-trial-to-assess-the-safety-and-immunogenicity-of-an-6079fa6b-39a7-4001-ab73-af233882a0e5.md)
- Safety & Immunogenicity of 426c.Mod.Core-C4b Vaccine With 3M-052-AF+Alum in Infants Perinatally Exposed to HIV But Uninfected
- Safety and Immunogenicity of Stabilized CH505 TF chTrimer Vaccination in Adults Living With HIV-1 on Suppressive Antiretroviral Therapy

### In development for (3)

- [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 1
- [Primary cutaneous T-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/primary-cutaneous-t-cell-non-hodgkin-lymphoma-256d9a2d-c476-5c4c-9735-e4de59228289.md) Phase 1
- [Zika virus infectious disease](https://trialight.com/data/condition/zika-virus-infectious-disease-0c94d5f5-bdfa-579d-9fd2-f389ab562163.md) Phase 1

### Targets (2)

- [TLR7](https://trialight.com/data/target/tlr7-425eff2f-0af1-599e-ad6a-8d06f0318c8f.md) Toll-like receptor 7 agonist
- [TLR8](https://trialight.com/data/target/tlr8-29f82fcd-6fe2-5c89-802e-29e5ac2cb926.md) Toll-like receptor 8 agonist

---

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