> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/telitacicept-29fd6e0f-15b8-4b2e-966c-3ba8f073e93b
> Record changed: 2026-10-13

# Telitacicept

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095293)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095293)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095293)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095293)

**Drug name**

Telitacicept

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095293)

### Other names (13)

- rituximab plus telitacicept
- telitacicept
- Telitacicept
- telitacicept \[INN\]
- Telitacicept \[WHO-DD\]
- Telitacicept 160 mg
- Telitacicept 160mg
- Telitacicept 240 mg
- Telitacicept 240mg
- Telitacicept 80 mg
- telitacicept inn
- telitacicept who dd
- Telitacicept-only group

## Identifiers

**CAS registry numbers**

- 2136630-26-5

**ChEMBL ID**

CHEMBL5095293

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095293)

**FDA ingredient codes (UNII)**

- 1FHM3D7Z49

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

telitacicept

**Type**

Peptide

**Drug name stem**

\-cept

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
APRIL

**Gene symbol**  
APRIL
- **Action**  
Binding

**Action type**  
Binding

**Target**  
BAFF

**Gene symbol**  
BAFF

### Investigated indications (8)

- **Condition**  
Scleroderma, Diffuse

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000404

**Subject identifier**  
D045743
- **Condition**  
Sjogren's Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000699

**Subject identifier**  
D012859
- **Condition**  
Antiphospholipid Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0002689

**Subject identifier**  
D016736
- **Condition**  
Glomerulonephritis, IGA

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004194

**Subject identifier**  
D005922
- **Condition**  
Nephrotic Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004255

**Subject identifier**  
D009404
- **Condition**  
Myasthenia Gravis

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004991

**Subject identifier**  
D009157
- **Condition**  
Lupus Nephritis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005761

**Subject identifier**  
D008181
- **Condition**  
Lupus Erythematosus, Systemic

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0007915

**Subject identifier**  
D008180

### Open Targets indications (26)

- **Condition identifier**  
EFO\_0000404

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000685
- **Condition identifier**  
EFO\_0000699

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0002689

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004194

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0004255

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0004991

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0005761

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0001873

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000831

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002869

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005019

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005342

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005377

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005556

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006702
- **Condition identifier**  
MONDO\_0007827

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007915

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008383

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0009688

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0010030

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0015925

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018013

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0019100

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0020108

**Highest recorded phase**  
2

And 1 more, listed on the interactive page.

### Reported adverse events (7)

- **Event**  
complement factor c3

**Reports**  
1

**Reporting signal score**

12.5681
- **Event**  
complement factor c3 increased

**Reports**  
3

**Reporting signal score**

30.5457
- **Event**  
hypoalbuminaemia

**Reports**  
5

**Reporting signal score**

32.8673
- **Event**  
hypocomplementaemia

**Reports**  
5

**Reporting signal score**

51.0345
- **Event**  
proteinuria

**Reports**  
5

**Reporting signal score**

27.9995
- **Event**  
systemic lupus erythematosus

**Reports**  
5

**Reporting signal score**

27.8863
- **Event**  
treatment failure

**Reports**  
5

**Reporting signal score**

22.1785

### Trial references (16)

- NCT04905212  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04905212)
- NCT05596708  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05596708)
- NCT05799287  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05799287)
- NCT05078710  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05078710)
- NCT06315530  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06315530)
- NCT05247203  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05247203)
- NCT05306574  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05306574)
- NCT05339217  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05339217)
- NCT05687526  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05687526)
- NCT05929248  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05929248)
- NCT05673993  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05673993)
- NCT05680480  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05680480)
- NCT05737160  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05737160)
- NCT06456580  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06456580)
- NCT06125405  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06125405)
- NCT06375005  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06375005)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (48)

- [A Single Dose Study to Investigate the Pharmacokinetics (PK) of Telitacicept Pre-filled Injection and Freeze-dried Powder Injection in Chinese Healthy Subjects](https://trialight.com/data/trial/a-single-dose-study-to-investigate-the-pharmacokinetics-pk-328a96aa-9bc8-4c22-a24c-41e79cb3fd64.md)
- A Study of Telitacicept for IgA Nephropathy (TELIGAN)
- A Study of Telitacicept for Injection (RC18) in Subjects With IgA Nephropathy
- A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis (UPSTREAM MG)
- A Study of Telitacicept for the Treatment of Moderately to Severely Active Systemic Lupus Erythematosus (REMESLE-1)
- A Study of Telitacicept for the Treatment of Moderately to Severely Active Systemic Lupus Erythematosus (REMESLE-2)
- A Study of Telitacicept in Lupus Nephritis
- A Study of Telitacicept in Patients With Ocular Myasthenia Gravis (OMG)
- A Study of Telitacicept in Subjects With Childhood-onset Systemic Lupus Erythematosus
- A Study on the Efficacy and Safety of Telitacicept in the Treatment of Children Ocular Myasthenia Gravis
- A Study to Evaluate the Efficacy and Safety of Telitacicept in Subjects With Active Primary Sjogren's Syndrome
- Chinese Adults With Kidney Disease
- Clinical Study on the Efficacy and Safety of Telitacicept in the Treatment of Pediatric IgA Nephropathy or IgA Vasculitis Nephritis
- Effect of Telitacicept on Antibody Titers in Primary APS Patients
- Efficacy and Immunological Evaluation of Telitacicept and Low Dose IL2 in the Treatment of Systemic Lupus Erythematosus
- Efficacy and Safety for Rituximab Combined With Telitacicept in the Treatment of ANCA-associated Vasculitis (TTCAAVREM)
- Efficacy and Safety for Telitacicept in the Remission Maintenance Treatment of ANCA-associated Vasculitis (TTCAZAREM)
- Efficacy and Safety of Efgartigimod Sequential Therapy with Telitacicept in Generalized Myasthenia Gravis
- Efficacy and Safety of Telitacicept Combined With Tofacitinib for Refractory Rheumatoid Arthritis
- Efficacy and Safety of Telitacicept for Prevention of Flares in SLE Patients

### In development for (8)

- Antiphospholipid syndrome Phase 2
- Diffuse scleroderma Phase 2
- [IgA glomerulonephritis](https://trialight.com/data/condition/iga-glomerulonephritis-f6f68a56-7253-54d9-9456-5d9ece4d1a52.md) Phase 3
- [Lupus nephritis](https://trialight.com/data/condition/lupus-nephritis-2794deed-1735-531d-b3ca-1e5d38aadc8a.md) Phase 2
- Myasthenia gravis Phase 3
- Nephrotic syndrome Phase 3
- [Sjogren syndrome](https://trialight.com/data/condition/sjogren-syndrome-a76424ca-3898-5b4e-82c0-867f8103dce0.md) Phase 3
- [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 3

### Other linked conditions (1)

- [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md)

---

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