> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/tegoprazan-f2335eec-d19e-4178-aa1b-90007a8fc240
> Record changed: 2026-10-13

# Tegoprazan

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

**Drug name**

Tegoprazan

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

**Molecular weight**

387.39

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

**Structure (SMILES)**

Cc1nc2cc(C(=O)N(C)C)cc(O\[C@H\]3CCOc4cc(F)cc(F)c43)c2\[nH\]1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

### Other names (39)

- bli5100
- BLI5100
- cj 12420
- Cj-12420
- CJ-12420
- CJ-12420 100 mg QD
- CJ-12420 100mg
- CJ-12420 100mg QD
- CJ-12420 200mg
- CJ-12420 50 mg QD
- CJ-12420 50mg
- CJ-12420 50mg QD
- IN-A001(Tegoprazan)
- lxi 15028
- Lxi-15028
- LXI-15028
- LXI-15028 100mg
- LXI-15028 200mg
- LXI-15028 50mg
- tegoprazan
- Tegoprazan
- Tegoprazan (C1)
- Tegoprazan (C2)
- Tegoprazan (C3)
- tegoprazan \[INN\]

And 14 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- A02BC09

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

**CAS registry numbers**

- 942195-55-3

**ChEMBL ID**

CHEMBL4297583

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

**InChIKey**

CLIQCDHNPDMGSL-HNNXBMFYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297583)

**PubChem compound IDs**

- 23582846

**FDA ingredient codes (UNII)**

- W017G7IF4S

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

tegoprazan

**Type**

Synthetic organic

**Drug name stem**

\-prazan

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (3)

- **Mechanism**  
Potassium-transporting ATPase blocker

**Action type**  
Blocker

**Target**  
Potassium-transporting ATPase

**Protein identifier**  
P20648
- **Mechanism**  
Potassium-transporting ATPase blocker

**Action type**  
Blocker

**Target**  
Potassium-transporting ATPase

**Protein identifier**  
P51164
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
ATP4A

**Gene symbol**  
ATP4A

**Protein identifier**  
P20648

**Median affinity**

6.28

**Affinity units**  
pIC50

### Open Targets mechanisms

- **Mechanism**  
Potassium-transporting ATPase blocker

**Action type**  
Blocker

**Target**  
Potassium-transporting ATPase

### Investigated indications (7)

- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Gastroesophageal Reflux

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003948

**Subject identifier**  
D005764
- **Condition**  
Duodenal Ulcer

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004607

**Subject identifier**  
D004381
- **Condition**  
Stomach Ulcer

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0009454

**Subject identifier**  
D013276
- **Condition**  
Helicobacter Infections

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000961

**Subject identifier**  
D016481
- **Condition**  
Laryngopharyngeal Reflux

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1001355

**Subject identifier**  
D057045
- **Condition**  
Peptic Ulcer

**Highest recorded phase**  
3

**Condition identifier**  
HP:0004398

**Subject identifier**  
D010437

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003948
- **Condition identifier**  
EFO\_0004607

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009454

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000961

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001355

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0004398
- **Condition identifier**  
HP\_0004398

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0001126

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005412

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006781

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007186

**Highest recorded phase**  
4

### Trial references (17)

- NCT02028663  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02028663)
- NCT02456935  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02456935)
- NCT02556021  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02556021)
- NCT02995239  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02995239)
- NCT03006874  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03006874)
- NCT03591653  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03591653)
- NCT03615677  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03615677)
- NCT04022096  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04022096)
- NCT04568772  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04568772)
- NCT02761512  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02761512)
- NCT04128917  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04128917)
- NCT05577468  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05577468)
- NCT05933031  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05933031)
- NCT04494269  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04494269)
- NCT04840550  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04840550)
- NCT05010954  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05010954)
- NCT05871398  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05871398)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

1

**Polar surface area**

67.45

**Calculated partition coefficient (ALogP)**

3.75

**Calculated partition coefficient (XLogP)**

3.2

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

28

**Molecular formula**

C20H19F2N3O3

**Monoisotopic mass**

387.13944780

**Natural product**

No

## Evidence counts

**Recorded assays**

18

**Active assays**

4

### Active assay types

- Confirmatory

## Related records

### Trials (73)

- A Multi-center, Randomized, Double-blind, Parallel-group, Placebo Controlled Phase III Study to Evaluate the Efficacy and Safety of LXI-15028 in Non-erosive Reflux Disease in Chinese Patients for 4 Weeks
- A Phase 1 Study of Tegoprazan on Healthy Male Volunteers
- A Phase 3 Study to Evaluate the Efficacy and Safety of Triple Therapy With CJ-12420 in H. Pylori Positive Patients
- A Phase I Study of LuoXin Innovate (LXI-15028) in Healthy Chinese Subjects to Evaluate the Pharmacokinetics, Safety and Tolerability.
- A Phase I Study of LX22001 for Injection in Healthy Subjects
- A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade
- A Study to Assess Safety and Immunogenicity of Conserved Mosaic HIV-1 Vaccines
- A Study to Compare the Pharmacokinetic Characteristics of CJ-12420
- A Study to Evaluate Effect of IN-A001 on Pharmacokinetics of Tacrolimus in Healthy Volunteers
- A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls
- A Study to Evaluate Safety, Tolerability, and PD of Tegoprazan on Healthy Male Volunteers
- [A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Erosive Esophagitis](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-bli5100-in-51a411c3-ac7d-409a-9ab7-19948da28005.md)
- A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Non-Erosive Reflux Disease
- A Study to Evaluate the Efficacy and Safety of Tegoprazan in GERD Patients With Nighttime Heartburn
- A Study to Evaluate the Long-Term Safety of BLI5100 in Patients With Gastroesophageal Reflux Disease
- A Study to Evaluate the Pharmacokinetics and Food-effect of IN-M00002 Tablet in Healthy Adult Volunteers
- Change of Gut Microbiome and Symptom After H.Pylori Eradication Therapy in Patients With Functional Dyspepsia
- Clinical Trial for the Comparative Evaluation of Acid Suppression and Symptom Management of Gastroesophageal Reflux Disease With the Administration of Tegoprazan or Pantoprazole
- Comparison of Two Dual Therapies in the First-line Treatment of Helicobacter Pylori Infection （SHARE2301）
- Drug Interaction Study Between Tegoprazan, Bismuth, Amoxicillin and Clarithromycin

### In development for (6)

- Duodenal ulcer Phase 3
- Gastric ulcer Phase 3
- Gastroesophageal reflux disease Phase 3
- [Helicobacter pylori infectious disease](https://trialight.com/data/condition/helicobacter-pylori-infectious-disease-ff5903ca-758b-5979-a633-075499e2938b.md) Phase 3
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- Peptic ulcer disease Phase 3

### Targets (2)

- [ATP4A](https://trialight.com/data/target/atp4a-cb311620-cbd7-5592-86bf-6eff6bf5e70e.md) Potassium-transporting ATPase blocker
- [ATP4B](https://trialight.com/data/target/atp4b-dd74ece5-dac6-5730-bcb3-d26c200dd49f.md) Potassium-transporting ATPase blocker

---

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