> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/tapinarof-4f1c2328-2e1b-4718-b242-8cce86524e6e
> Record changed: 2026-10-13

# Tapinarof

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

First approval year

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

## Development status

**First approval year**

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

**Drug name**

Tapinarof

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

**Molecular weight**

254.33

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

**Structure (SMILES)**

CC(C)c1c(O)cc(/C=C/c2ccccc2)cc1O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

### Brand names (2)

- vtama
- Vtama

### Other names (27)

- benvitimod
- Benvitimod
- Benvitimod Cream
- gsk 2894512
- GSK-2894512
- gsk2894512
- GSK2894512
- GSK2894512 cream
- GSK2894512 Cream
- GSK2894512 Topical Cream
- tapinarof
- Tapinarof
- Tapinarof \[INN\]
- Tapinarof \[USAN\]
- Tapinarof \[WHO-DD\]
- tapinarof inn
- tapinarof usan
- tapinarof who dd
- vtama
- Vtama
- VTAMA (tapinarof) cream, 1%
- VTAMA®
- VTAMA® (tapinarof) Cream 1%
- Vtama® (Tapinarof) Cream, 1%
- wbi 1001

And 2 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- D05AX07

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

**CAS registry numbers**

- 79338-84-4

**ChEMBL ID**

CHEMBL259571

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

**InChIKey**

ZISJNXNHJRQYJO-CMDGGOBGSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL259571)

**PubChem compound IDs**

- 6439522

**RxNorm IDs (RxCUI)**

- 2602286

**FDA ingredient codes (UNII)**

- 84HW7D0V04

## Regulatory information

### United States

**Applicant**

ORGANON LLC

**Approval date**

23 May 2022

**Application number**

NDA215272

### Other regulatory facts

**Patents**

12

**Designations**

0

**Earliest recorded loss of exclusivity**

18 Dec 2039

**First in class**

Yes

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

tapinarof

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- topical

### Mechanisms of action (2)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
aryl hydrocarbon receptor

**Gene symbol**  
AHR

**Protein identifier**  
P35869

**Affinity units**  
pKd

**Primary target**  
Yes
- **Mechanism**  
Aryl hydrocarbon receptor agonist

**Action type**  
Agonist

**Target**  
Aryl hydrocarbon receptor

**Protein identifier**  
P35869

### Open Targets mechanisms

- **Mechanism**  
Aryl hydrocarbon receptor agonist

**Action type**  
Agonist

**Target**  
Aryl hydrocarbon receptor

### Investigated indications (2)

- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Psoriasis

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000676

**Subject identifier**  
D011565

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000274
- **Condition identifier**  
EFO\_0000676
- **Condition identifier**  
EFO\_0003834
- **Condition identifier**  
EFO\_1001494
- **Condition identifier**  
EFO\_1001494

**Highest recorded phase**  
4
- **Condition identifier**  
HP\_0000982

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005083

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005282

**Highest recorded phase**  
1

### Trial references (15)

- NCT01098721  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01098721)
- NCT03956355  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03956355)
- NCT03983980  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03983980)
- NCT04042103  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04042103)
- NCT04053387  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04053387)
- NCT05064748  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05064748)
- NCT05172726  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05172726)
- NCT05789576  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05789576)
- NCT05981118  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05981118)
- NCT06103695  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06103695)
- NCT05014568  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05014568)
- NCT05032859  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05032859)
- NCT05142774  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05142774)
- NCT05186805  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05186805)
- NCT05326672  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05326672)

## Dosing

**Route**

Topical

**How often**

Once daily

### Conditions of use (3)

- Apply a thin layer to affected areas
- Not for oral, ophthalmic, or intravaginal use
- Wash hands after application unless for hands use

## Chemical properties

**Hydrogen bond acceptors**

2

**Hydrogen bond donors**

2

**Polar surface area**

40.46

**Calculated partition coefficient (ALogP)**

4.39

**Calculated partition coefficient (XLogP)**

4.6

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

19

**Molecular formula**

C17H18O2

**Monoisotopic mass**

254.130679813

**Natural product**

Yes

## National Drug Codes

- 81672-5051

## Evidence counts

**Recorded assays**

27

**Active assays**

6

### Active assay types

- Confirmatory

## Pharmacologic actions

- Dermatologic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D003879.html)

## Related records

### Trials (35)

- A Dose-Finding Study of GSK2894512 Cream in Subjects With Atopic Dermatitis (AD)
- A Dose-Finding Study of GSK2894512 Cream in Subjects With Plaque Psoriasis
- A Safety/Efficacy Study of a Non-steroid, Topical Cream Treatment of Psoriasis Over 12-weeks
- A Single Dose Phase I Exploratory Study in Healthy Volunteers With GSK2894512 Cream
- [A Study Comparing Tapinarof Cream 1% and Vtama® Cream 1% in the Treatment of Plaque Psoriasis.](https://trialight.com/data/trial/a-study-comparing-tapinarof-cream-1-and-vtama-cream-1-in-the-b7e05f34-7d79-45f1-9537-74aa307bb47e.md)
- A Study to Evaluate Pharmacokinetic (PK), Safety and Tolerability of GSK2894512 in Healthy Adult Subjects
- A Study to Evaluate the Irritation Potential of GSK2894512 Cream on Skin in Healthy Subjects
- A Study to Investigate Efficacy and Safety of VTAMA (Tapinarof) Cream, 1% in Intertriginous Plaque Psoriasis
- A Study to Investigate Efficacy and Safety of VTAMA® (Tapinarof) Cream, 1% in Plaque Psoriasis in the Head and Neck Region
- A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis
- Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant)
- Efficacy and Safety of Benvitimod Cream in Cutaneous T-Cell Lymphoma
- Efficacy and Safety of Benvitimod Cream in the Retreatment of Mild to Moderate Psoriasis
- Efficacy of Topical Tapinarof Versus Betamethasone in the Treatment of Plaque Psoriasis
- GSK2894512 Vehicle-Controlled Study for Adult Plaque Psoriasis
- Long Term Extension Study of Tapinarof Cream, 1% for Subjects With Atopic Dermatitis
- Long Term Extension Study of Tapinarof for Plaque Psoriasis in Adults (3003)
- Maximal Use Study of Tapinarof Cream, 1% in Adults With Extensive Plaque Psoriasis
- Maximal Use Study of Tapinarof Cream, 1% in Pediatric Subjects With Extensive Atopic Dermatitis
- Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream

### Approved for (1)

- [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md)

### In development for (1)

- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 3

### Other linked conditions (1)

- [Cutaneous lupus erythematosus](https://trialight.com/data/condition/cutaneous-lupus-erythematosus-d8209c16-c236-521f-8fd1-cd89b5810e23.md)

### Targets (1)

- [AHR](https://trialight.com/data/target/ahr-616ad9f7-ec8c-5c0c-be67-29034595cefb.md) Aryl hydrocarbon receptor agonist

---

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