> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/sy-5609-208fe9a6-9c85-421c-aa4c-a82fa21f4157
> Record changed: 2026-10-13

# SY-5609

Highest phase reached

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

**Drug name**

SY-5609

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

**Molecular weight**

490.47

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

**Structure (SMILES)**

CC1(C)CC\[C@H\](Nc2ncc(C(F)(F)F)c(-c3c\[nH\]c4c(P(C)(C)=O)c(C#N)ccc34)n2)CN1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

### Other names (8)

- sy 5609
- Sy 5609
- SY 5609 \[WHO-DD\]
- sy 5609 who dd
- Sy-5609
- SY-5609
- sy5609
- SY5609

## Identifiers

**CAS registry numbers**

- 2417302-07-7

**ChEMBL ID**

CHEMBL5090754

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

**InChIKey**

JDJOUBVVSQDIRC-AWEZNQCLSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5090754)

**PubChem compound IDs**

- 146662729

**FDA ingredient codes (UNII)**

- TW6044C3O6

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

SY-5609

**Type**

Synthetic organic

### Mechanisms of action (3)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
cyclin dependent kinase 7

**Gene symbol**  
CDK7

**Protein identifier**  
P50613

**Median affinity**

7.15

**Affinity units**  
pKd
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
cyclin dependent kinase 9

**Gene symbol**  
CDK9

**Protein identifier**  
P50750

**Median affinity**

5.72

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
cyclin dependent kinase 12

**Gene symbol**  
CDK12

**Protein identifier**  
Q9NYV4

**Median affinity**

5.77

**Affinity units**  
pIC50

### Investigated indications (4)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Small Cell Lung Carcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000702

**Subject identifier**  
D055752
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002618

**Subject identifier**  
D010190
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943

### Open Targets indications (3)

- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
1

### Trial references

- NCT04247126  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04247126)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

3

**Polar surface area**

106.49

**Calculated partition coefficient (ALogP)**

4.71

**Calculated partition coefficient (XLogP)**

2.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

4

**Heavy atoms**

34

**Molecular formula**

C23H26F3N6OP

**Monoisotopic mass**

490.18578096

**Natural product**

No

## Evidence counts

**Recorded assays**

244

**Active assays**

118

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (2)

- [A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)](https://trialight.com/data/trial/a-study-evaluating-the-safety-and-efficacy-of-targeted-dd62fe2e-2b36-4ddc-82bc-7f1549d780cc.md)
- A Study of SY 5609, a Selective CDK7 Inhibitor, in Advanced Solid Tumors

### In development for (4)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1
- Exocrine pancreatic carcinoma Phase 1
- Neoplasm Phase 1
- [Small cell lung carcinoma](https://trialight.com/data/condition/small-cell-lung-carcinoma-505ad14d-ce79-5398-b171-f724c32e1b4e.md) Phase 1

---

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