> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/suzetrigine-38fea8c9-094b-4a0f-a3ac-8b8135055326
> Record changed: 2026-10-13

# Suzetrigine

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

**Drug name**

Suzetrigine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

**Molecular weight**

473.4

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

**Structure (SMILES)**

COc1c(\[C@H\]2\[C@H\](C(=O)Nc3ccnc(C(N)=O)c3)O\[C@@\](C)(C(F)(F)F)\[C@H\]2C)ccc(F)c1F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

### Other names (27)

- journavx
- JOURNAVX
- oral suzetrigine
- suzetrigina
- Suzetrigina
- SUZETRIGINA
- suzetrigine
- Suzetrigine
- SUZETRIGINE
- Suzetrigine (SUZ)
- suzetrigine \[INN\]
- SUZETRIGINE \[USAN\]
- Suzetrigine \[WHO-DD\]
- suzetrigine 100mg
- suzetrigine inn
- suzetrigine usan
- suzetrigine who dd
- vrt 1737548
- VRT-1737548
- vx 548
- Vx-548
- VX-548
- vx548
- VX548
- vxc 548

And 2 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 2649467-58-1

**ChEMBL ID**

CHEMBL5314487

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

**InChIKey**

XSQUJFKRXZMOKA-PAFIKIDNSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314487)

**PubChem compound IDs**

- 156445116

**RxNorm IDs (RxCUI)**

- 2704819

**FDA ingredient codes (UNII)**

- LOG73M21H5

## Regulatory information

### Other regulatory facts

**Patents**

1

**Designations**

4

**Earliest recorded loss of exclusivity**

4 Dec 2040

**First in class**

No

**Fast track**

Yes

**Breakthrough designation**

Yes

**Orphan designation**

No

**Priority review**

Yes

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

suzetrigine

**Type**

Synthetic organic

**Drug name stem**

\-trigine

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (3)

- **Action**  
Binding

**Action type**  
Binding

**Target**  
Nav1.8

**Gene symbol**  
SCN10A

**Protein identifier**  
Q9Y5Y9

**Median affinity**

7.19

**Affinity units**  
pKd
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
Nav1.8

**Gene symbol**  
SCN10A

**Protein identifier**  
Q9Y5Y9

**Median affinity**

9.57

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Nav1.8

**Gene symbol**  
SCN10A

**Protein identifier**  
Q9Y5Y9

**Median affinity**  
8

**Affinity units**  
pIC50

### Investigated indications (4)

- **Condition**  
Pain

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D010146
- **Condition**  
Acute Pain

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003843

**Subject identifier**  
D059787
- **Condition**  
Neuralgia

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0009430

**Subject identifier**  
D009437
- **Condition**  
Diabetic Neuropathies

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000783

**Subject identifier**  
D003929

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0009430
- **Condition identifier**  
EFO\_0009806

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0012531

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0021667

### Reported adverse events

- **Event**  
paraesthesia

**Reports**  
5

**Reporting signal score**

10.1968

### Trial references (12)

- NCT04977336  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04977336)
- NCT05034952  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05034952)
- NCT05455502  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05455502)
- NCT05541471  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05541471)
- NCT05553366  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05553366)
- NCT05558410  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05558410)
- NCT05560464  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05560464)
- NCT05635110  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05635110)
- NCT05661734  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05661734)
- NCT05818852  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05818852)
- NCT05851157  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05851157)
- NCT05660538  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05660538)

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

2

**Polar surface area**

103.54

**Calculated partition coefficient (ALogP)**

3.55

**Calculated partition coefficient (XLogP)**

3

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

33

**Molecular formula**

C21H20F5N3O4

**Monoisotopic mass**

473.13739694

**Natural product**

No

## National Drug Codes

- 51167-548
- 85766-243

## Evidence counts

**Recorded assays**

3

**Active assays**

3

### Active assay types

- Confirmatory

## Related records

### Trials (47)

- A Microneurography Study of NaV1.8 Inhibition in Healthy Adults
- A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries
- A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
- A Single-arm Study to Evaluate Safety and Effectiveness of VX-548 for Acute Pain
- A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
- A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
- A Study Of Opioid Avoidance In Surgery Through Integrating Suzetrigine
- A Study of Suzetrigine (SUZ) Spray-dried Dispersion (SSD) in Healthy Adult Panelists
- A Study to Evaluate the Effect of Food on the Pharmacokinetics of VX-548
- A Study to Evaluate the Effect of VX-548 on the QT/QTc Interval in Healthy Participants
- A Study to Evaluate the Pharmacokinetic Drug-drug Interactions Between VX-548, Midazolam, and Digoxin
- A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation and Strength of Suzetrigine
- A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-548
- Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery
- Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty
- Effects of Efavirenz on the Pharmacokinetics of Suzetrigine in Healthy Participants
- Evaluating Suzetrigine for Pain Control Following TKA
- Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy
- [Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty](https://trialight.com/data/trial/evaluation-of-efficacy-and-safety-of-suzetrigine-for-acute-2527d0d7-9b13-4646-9047-f5caf77b9ecf.md)
- [Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy](https://trialight.com/data/trial/evaluation-of-efficacy-and-safety-of-suzetrigine-for-pain-35669585-f908-4209-baa9-ccb0b2730dbd.md)

### In development for (2)

- Diabetic neuropathy Phase 2
- Neuralgia Phase 1

---

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