> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/sutidiazine-d3181b03-916f-4271-82bc-8a740fd402e5
> Record changed: 2026-10-13

# Sutidiazine

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

**Drug name**

Sutidiazine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

**Molecular weight**

465.58

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

**Structure (SMILES)**

Cc1nc(Nc2ncc(N3CCN(C)\[C@H\](C)C3)c(Nc3cc(C)n(C)n3)n2)cc(C2CC2)c1F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

### Other names (17)

- mmv 253
- Mmv-253
- mmv253
- MMV253
- sutidiazina
- Sutidiazina
- sutidiazine
- Sutidiazine
- sutidiazine \[INN\]
- sutidiazine inn
- zy 19489
- zy 19489 capsule arm 1
- Zy-19489
- zy19489
- ZY19489
- zy19489 capsule
- ZY19489 Capsule

## Identifiers

**CAS registry numbers**

- 1821293-40-6

**ChEMBL ID**

CHEMBL4284447

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

**InChIKey**

HKPQFVAUXAZCDY-OAHLLOKOSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4284447)

**PubChem compound IDs**

- 92045019

**FDA ingredient codes (UNII)**

- VL8W9427Y4

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

sutidiazine

**Type**

Synthetic organic

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications (3)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005920

**Highest recorded phase**  
1

## Chemical properties

**Hydrogen bond acceptors**

9

**Hydrogen bond donors**

2

**Polar surface area**

87.03

**Calculated partition coefficient (ALogP)**

3.87

**Calculated partition coefficient (XLogP)**

4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

6

**Heavy atoms**

34

**Molecular formula**

C24H32FN9

**Monoisotopic mass**

465.27647022

**Natural product**

No

## Evidence counts

**Recorded assays**

11

**Active assays**

3

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Cardiac potassium channel inhibition

**Median**

33,000

**Mean**

33,000

**Minimum**

33,000

**Maximum**

33,000

**Unit**

nM

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- IC50

#### Oral bioavailability

**Median**

80

**Mean**

80

**Minimum**

80

**Maximum**

80

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (36)

- A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors
- A Phase II Study of Ivonescimab Combined with Cadonilimab and Chemotherapy in Extensive-stage Small Cell Lung Cancer
- A Study of Perpetrator Drug Interactions of Enasidenib in AML Patients
- A Study Of Zy-19489 Administered Via Oral Route To Investigate The Safety, Tolerability And Pharmacokinetics In Healthy Adult Human Subjects
- A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain
- A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion
- A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
- Acetaminophen Transfer Across the Placenta and the Assessment of Fetal Well-being
- Adebrelimab With Chemoradiotherapy and Surgery for G/GEJ
- Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
- Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma
- Clinical Study Phase II of L19IL2 in Combination With Dacarbazine in Patients With Metastatic Melanoma
- [Comparison of the Safety, Efficacy and Pharmacokinetics of DehydraTECH -CBD and DehydraTECH-GLP1 Agonists Alone or in Combination, in Overweight or Obese, Pre- and Type 2 Diabetic Participants](https://trialight.com/data/trial/comparison-of-the-safety-efficacy-and-pharmacokinetics-of-bc201e3e-46b9-4b92-b5f5-f998b9bef70b.md)
- CURE-H. Pylori: A Trial on the Combination of Anti-Ulcerants and Levofloxacin-Based Therapy for Helicobacter Pylori Eradication
- Dolutegravir + Rilpivirine Switch Study (DORISS)
- Efficacy of Oral Serratiopaptidase Vs Dexamethasone on Post-Operative Inflammation After Exodontia. An Experience at Tertiary Care Hospital Karachi Pakistan.
- Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction
- Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma
- Hydrocortisone in the Treatment of Intrusions in Patients With Posttraumatic Stress Disorder
- Immunodynamics-Guided Optimization of Individualized Immunochemotherapy in Advanced Driver-Negative NSCLC: A Randomized Trial

### In development for (1)

- Neoplasm Phase 2

---

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