> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/surzetoclax-41b29318-7056-493b-8cc3-b3203d3517b1
> Record changed: 2026-11-04

# Surzetoclax

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

**Drug name**

Surzetoclax

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

**Molecular weight**

1,039.65

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

**Structure (SMILES)**

CO\[C@@H\]1CC\[C@@H\](CNc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN5CC6=C(c7ccc(Cl)cc7)CC(C)(C)C\[C@H\]6OCCCOC\[C@@H\]5C4)cc3N3CCCOc4nc5\[nH\]ccc5cc43)cc2\[N+\](=O)\[O-\])OC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

### Other names (14)

- a 1944798 0
- A-1944798.0
- abbv 453
- ABBV 453 \[WHO-DD\]
- abbv 453 who dd
- ABBV-453
- d erythro hexitol 1 5 anhydro 6 4 4 4as 10ar 14 4 chlorophenyl 1 2 4a 5 8 9 10a 11 13 15 decahydro 12 12 dimethyl 7h 12h pyrazino 2 1 g 1 5 8 benzodioxaazacycloundecin 3 4h yl 2 3 4 dihydro 2h pyrrolo 3 2 5 6 pyrido 2 3 b 1 4 oxazepin 1 7h yl benzoyl amino sulfonyl 2 nitrophenyl amino 3 4 6 trideoxy 2 o methyl
- D-erythro-Hexitol, 1,5-anhydro-6-\[\[4-\[\[\[4-\[(4aS,10aR)-14-(4-chlorophenyl)-1,2,4a,5,8,9,10a,11,13,15-decahydro-12,12-dimethyl-7H,12H-pyrazino\[2,1-g\]\[1,5,8\]benzodioxaazacycloundecin-3(4H)-yl\]-2-(3,4-dihydro-2H-pyrrolo\[3′,2′:5,6\]pyrido\[2,3-b\]\[1,4\]oxazepin-1(7H)-yl)benzoyl\]amino\]sulfonyl\]-2-nitrophenyl\]amino\]-3,4,6-trideoxy-2-O-methyl-
- surzetoclax
- Surzetoclax
- surzetoclax \[INN\]
- SURZETOCLAX \[USAN\]
- surzetoclax inn
- surzetoclax usan

## Identifiers

**CAS registry numbers**

- 2858632-01-4

**ChEMBL ID**

CHEMBL6068032

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

**InChIKey**

AWGQQZVAXXLVMT-ORYVFAGJSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068032)

**PubChem compound IDs**

- 169450714

**FDA ingredient codes (UNII)**

- C3TU3CHH6L

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-toclax

### Investigated indications

- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369

### Open Targets indications (2)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0005070

## Chemical properties

**Calculated partition coefficient (XLogP)**

7.8

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Heavy atoms**

73

**Molecular formula**

C53H63ClN8O10S

**Monoisotopic mass**

1038.4076391

**Natural product**

No

## Evidence counts

**Recorded assays**

4

**Active assays**

4

### Active assay types

- Confirmatory

## Related records

### Trials (3)

- A Study Assessing Adverse Event and How Oral ABBV-453 Moves Through the Body in Adult Participants With Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
- [A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)](https://trialight.com/data/trial/a-study-to-assess-adverse-events-and-change-in-disease-74299213-ddfe-43d4-9c48-0a5119053db7.md)
- A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets

### In development for (1)

- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 2

---

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