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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/surovatamig-7faf9e34-10f0-400f-bdb7-010815f61c05 > Record changed: 2026-10-13 # Surovatamig Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068301) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068301) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068301) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068301) **Drug name** Surovatamig Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068301) ### Other names (22) - azd 0486 - AZD-0486 - azd0486 - Azd0486 - AZD0486 - AZD0486 IV - h gamma4 heavy chain anti cd3d cd3e dimer homo sapiens 1 450 vh homo sapiens ighv3 9 01 100 ighd ighj4 01 100 cdr imgt 8 8 16 26 33 51 58 97 112 1 123 homo sapiens ighg4 01 ng4m a ch2 l92 g4v5 h p10 g4v4 ch2 a1 3 a1 2 g4v32 ch3 w22 knob ch1 124 221 hinge 1 12 s10 p 231 222 233 ch2 f1 3 a 237 l1 2 a 238 l92 312 234 343 ch3 t22 w 369 344 448 chs 449 450 124 450 137 214 disulfide with l kappa light chain anti cd3d cd3e homo sapiens 1 214 v kappa homo sapiens igkv3 15 01 100 igkj1 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 v101 c kappa a45 1 153 v101 191 108 214 vh g4 h ch2 ch3 heavy chain anti cd19 humanized and homo sapiens 1 345 humanized vh homo sapiens ighv3 7 01 91 8 ighd ighj4 01 92 9 w118 r 106 cdr imgt 8 8 9 26 33 51 58 97 105 1 116 homo sapiens ighg4 01 h ch2 ch3 g4v5 h p10 ng4m a ch2 l92 g4v4 ch2 a1 3 a1 2 g1v33 ch3 s22 a24 v86 hole hinge 1 12 s10 p 126 117 128 ch2 f1 3 a 132 l1 2 a 133 l92 207 129 238 ch3 t22 s 264 l24 a 266 y86 v 305 239 343 chs 344 345 117 345 dimer 229 124 232 127 bisdisulfide produced in a cell line from chinese hamster ovary cho cells derived from the cell line cho k1 glycoform alfa - H-gamma4 heavy chain anti-CD3D/CD3E dimer, Homo sapiens (1-450) \[VH (Homo sapiens IGHV3-9\*01 (100%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[8.8.16\] (26-33.51-58.97-112)) (1-123)-Homo sapiens IGHG4\*01 nG4m(a) CH2 L92, G4v5 h P10, G4v4 CH2 A1.3, A1.2, G4v32 CH3 W22 (knob) (CH1 (124-221), hinge 1-12 S10>P (231) (222-233), CH2 F1.3>A (237), L1.2>A (238), L92 (312) (234-343), CH3 T22>W (369) (344-448), CHS (449-450)) (124-450)\], (137-214')-disulfide with L-kappa light chain anti-CD3D-CD3E Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV3-15\*01 (100%) -IGKJ1\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')\]; VH-G4(h-CH2-CH3) heavy chain anti-CD19, humanized and Homo sapiens (1''-345'') \[humanized VH (Homo sapiens IGHV3-7\*01 (91.8%) -(IGHD) -IGHJ4\*01 (92.9%) W118>R (106''), CDR-IMGT \[8.8.9\] (26''-33''.51''-58''.97''-105'')) (1''-116'')-Homo sapiens IGHG4\*01 h-CH2-CH3, G4v5 h P10,nG4m(a) CH2 L92, G4v4 CH2 A1.3, A1.2, G1v33 CH3 S22, A24, V86 (hole) (hinge 1-12 S10>P (126'') (117''-128''), CH2 F1.3>A (132''), L1.2>A (133''), L92 (207'') (129''-238''), CH3 T22>S (264''), L24>A (266''), Y86>V (305'') (239''-343''), CHS (344''-345'')) (117''-345'')\]; dimer (229-124'':232-127'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa - immunoglobulin (H-gamma4\_L-kappa)\_VH-G4(h-CH2-CH3), anti-\[Homo sapiens CD3D (CD3 delta) and CD3E (CD3 epsilon, Leu-4) dimer\] and anti-\[Homo sapiens CD19 (B lymphocyte surface antigen B4, Leu-12)\], Homo sapiens and humanized monoclonal antibody asymetric, bispecific, bivalent - Immunoglobulin G4 \[231-proline,237-alanine,238-alanine,369-tryptophan\], bispecific, anti-(human CD3 antigen) (human monoclonal AZD0486 γ4-chain) disulfide with human monoclonal AZD0486 κ-chain, (229→124′),(232→127′)-bis(disulfide) with immunoglobulin \[126-proline,132-alanine,133-alanine\] anti-(CD19 antigen) (human single-domain variable region) fusion protein with 219-447-immunoglobulin G4 \[228-proline,234-alanine,235-alanine,366-serine,368-alanine,407-valine\] (human monoclonal AZD0486 γ4-chain) - immunoglobulin g4 231 proline 237 alanine 238 alanine 369 tryptophan bispecific anti human cd3 antigen human monoclonal azd0486 γ4 chain disulfide with human monoclonal azd0486 κ chain 229 124 232 127 bis disulfide with immunoglobulin 126 proline 132 alanine 133 alanine anti cd19 antigen human single domain variable region fusion protein with 219 447 immunoglobulin g4 228 proline 234 alanine 235 alanine 366 serine 368 alanine 407 valine human monoclonal azd0486 γ4 chain - immunoglobulin h gamma4 l kappa vh g4 h ch2 ch3 anti homo sapiens cd3d cd3 delta and cd3e cd3 epsilon leu 4 dimer and anti homo sapiens cd19 b lymphocyte surface antigen b4 leu 12 homo sapiens and humanized monoclonal antibody asymetric bispecific bivalent - surovatamig - Surovatamig - surovatamig \[INN\] - SUROVATAMIG \[USAN\] - Surovatamig \[WHO-DD\] - surovatamig inn - surovatamig usan - surovatamig who dd - tnb 486 - TNB-486 ## Identifiers **CAS registry numbers** - 2892667-02-4 **ChEMBL ID** CHEMBL6068301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068301) **FDA ingredient codes (UNII)** - 3QW12I37H1 ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Drug name stem** \-mig ### Investigated indications (2) - **Condition** Leukemia, Biphenotypic, Acute **Highest recorded phase** 1 **Condition identifier** EFO:0000094 **Subject identifier** D015456 - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (14) - **Condition identifier** EFO\_0000094 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_1001938 **Highest recorded phase** 2 - **Condition identifier** HP\_0000093 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004948 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004967 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005376 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007915 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008383 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0015759 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018876 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018906 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0018908 **Highest recorded phase** 2 ### Trial references - NCT06137118 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06137118) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (6) - **Component** Heavy chain: H-gamma4 anti-CD3D/CD3E (knob) (H) **Type** Protein **Sequence** EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGISWNSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKDSRGYGDYRLGGAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK - **Component** Heavy chain: H-gamma4 anti-CD19 (hole) (H'') **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGFSFSDFWMSWVRQAPGKGLEWVATISQAGSEKDYVDSVKGRFTISRDNAKKSLYLQMNSLRAEDTAVYYCASGVYSFDYRGQGTLVTVSSESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 134'-194' $ 137-214' $ 150-206 $ 159''-219'' $ 229-124'' $ 232-127'' $ 264-324 $ 265''-323'' $ 370-428 - **Component** Glycosylation sites (N) **Sequence** 300 $ 195'' - **Component** Glycosylation sites (N) **Sequence** 299 $ 291'' - **Component** Heavy chain: anti-CD22 G4(VH-h-CH2-CH3) (H'') **Type** Protein **Sequence** EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## Related records ### Trials (10) - A Study Comparing a New Drug (Surovatamig) With Standard Radiotherapy With or Without Rituximab in Adults With Limited Stage Nodal Follicular Lymphoma - A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma - [A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies](https://trialight.com/data/trial/a-study-of-azd0486-monotherapy-or-in-combination-with-other-46d632fc-c1a6-4f86-bce7-6e88deec222b.md) - [A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients](https://trialight.com/data/trial/a-study-of-surovatamig-azd0486-plus-rituximab-in-previously-44c157a0-9366-48d5-b958-317565b0e0f7.md) - A Study to Assess the Effect of Surovatamig in Adult Participants With Antibody-mediated Kidney Disease - AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL - AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia - Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants - [Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL](https://trialight.com/data/trial/surovatamig-azd0486-as-monotherapy-in-participants-with-b262f795-e696-407b-9d95-d62e07667602.md) - Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV) ### In development for (3) - B-cell acute lymphoblastic leukemia Phase 1 - [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) Phase 2 - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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