> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/suramin-e04dff6b-136c-4793-99fa-047a163fab77
> Record changed: 2026-10-13

# Suramin

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

**Drug name**

Suramin

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

**Molecular weight**

1,297.3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

**Structure (SMILES)**

Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C)c2)c1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

### Other names (22)

- 8 8 carbonylbis imino 3 1 phenylenecarbonylimino 4 methyl 3 1 phenylene carbonylimino bis 1 3 5 naphthalenetrisulfonic acid
- 8 8 ureylenebis m phenylenecarbonylimino 4 methyl m phenylene carbonylimino di 1 3 5 naphthalenetrisulfonic acid
- 8,8'-(CARBONYLBIS(IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID
- 8,8'-(UREYLENEBIS(M-PHENYLENECARBONYLIMINO(4-METHYL-M-PHENYLENE)CARBONYLIMINO))DI-1,3,5-NAPHTHALENETRISULFONIC ACID
- farma
- Farma
- farma 939
- FARMA-939
- fourneau
- Fourneau
- metaret
- Metaret
- naganol
- Naganol
- nsc 34936
- NSC-34936
- suramin
- Suramin
- Suramin \[WHO-DD\]
- suramin who dd
- suramine
- Suramine

## Identifiers

**CAS registry numbers**

- 145-63-1

**ChEMBL ID**

CHEMBL265502

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

**InChIKey**

FIAFUQMPZJWCLV-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL265502)

**RxNorm IDs (RxCUI)**

- 10256

**FDA ingredient codes (UNII)**

- 6032D45BEM

### PubChem compound IDs (3)

- 5361
- 4261196
- 135973538

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

2

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

suramin

**Type**

Synthetic organic

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (8)

- **Action**  
Activator

**Action type**  
ACTIVATOR

**Target**  
RyR1

**Gene symbol**  
RYR1

**Protein identifier**  
P21817
- **Action**  
Activator

**Action type**  
ACTIVATOR

**Target**  
RyR2

**Gene symbol**  
RYR2

**Protein identifier**  
Q92736
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
P2Y2 receptor

**Gene symbol**  
P2RY2

**Protein identifier**  
P41231

**Median affinity**

4.3

**Affinity units**  
pIC50
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
P2Y1 receptor

**Gene symbol**  
P2RY1

**Protein identifier**  
P47900

**Median affinity**

5.3

**Affinity units**  
pKi
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
P2X3

**Gene symbol**  
P2RX3

**Protein identifier**  
P56373

**Median affinity**

4.83

**Affinity units**  
pIC50
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
P2Y6 receptor

**Gene symbol**  
P2RY6

**Protein identifier**  
Q15077

**Median affinity**  
4

**Affinity units**  
pKB
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
P2Y11 receptor

**Gene symbol**  
P2RY11

**Protein identifier**  
Q96G91

**Affinity units**  
pIC50
- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
P2Y13 receptor

**Gene symbol**  
P2RY13

**Protein identifier**  
Q9BPV8

**Median affinity**

5.6

**Affinity units**  
pIC50

### Open Targets mechanisms

- **Mechanism**  
Acidic fibroblast growth factor inhibitor

**Action type**  
Inhibitor

**Target**  
Fibroblast growth factor 1

### DrugCentral mechanisms (5)

- **Action type**  
Antagonist

**Gene symbol**  
P2RY2

**Protein identifier**  
P41231

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Antagonist

**Gene symbol**  
P2RY1

**Protein identifier**  
P47900

**Organism**  
Homo sapiens

**Target development level**  
Chemical evidence
- **Action type**  
Antagonist

**Gene symbol**  
P2RY6

**Protein identifier**  
Q15077

**Organism**  
Homo sapiens

**Target development level**  
Chemical evidence
- **Action type**  
Antagonist

**Gene symbol**  
P2RY11

**Protein identifier**  
Q96G91

**Organism**  
Homo sapiens

**Target development level**  
Biological evidence
- **Action type**  
Antagonist

**Gene symbol**  
P2RY13

**Protein identifier**  
Q9BPV8

**Organism**  
Homo sapiens

**Target development level**  
Chemical evidence

### Investigated indications

- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289

### Open Targets indications (5)

- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005225

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005258

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005459

**Highest recorded phase**  
1

### Reported adverse events (2)

- **Event**  
chest pain

**Reports**  
4

**Reporting signal score**

11.5054
- **Event**  
electromyogram abnormal

**Reports**  
1

**Reporting signal score**

7.73814

### Trial references

- NCT01038752  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01038752)

## Chemical properties

**Calculated partition coefficient (XLogP)**

1.5

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Heavy atoms**

86

**Molecular formula**

C51H40N6O23S6

**Monoisotopic mass**

1296.0469086

**Natural product**

Yes

## Evidence counts

**Recorded assays**

1,785

**Active assays**

275

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Pharmacologic actions

- Antinematodal Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000969.html)
- Antineoplastic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000970.html)
- Trypanocidal Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D014344.html)

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

0.00023

**Mean**

0.00023

**Minimum**

0.00023

**Maximum**

0.00023

**Unit**

unitless

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

## Related records

### Trials (21)

- A Phase I Trial Using Suramin to Treat Superficial Transitional Cell Carcinoma of the Bladder
- A Phase II Trial of Leuprolide + Flutamide + Suramin in Untreated Poor Prognosis Prostate Carcinoma
- Combination Chemotherapy With Suramin Plus Doxorubicin in Treating Patients With Advanced Solid Tumors
- Docetaxel +/- Suramin in 2nd Line Advanced Non-Small Cell Lung Cancer
- Efficacy, Safety and Immunogenicity of Rotavirus RV3 Vaccine (Bio Farma) in Neonates
- Evaluation of Non-cytotoxic Suramin as a Chemosensitizer in Non-small Cell Lung Cancer
- Fluorouracil and Low-Dose Suramin as Chemosensitization in Treating Patients With Metastatic Renal Cell (Kidney) Cancer
- Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer
- Low, Intermediate, or High Dose Suramin in Treating Patients With Hormone-Refractory Prostate Cancer
- [Phase I/II, Open Label, Randomized, Safety and Immunogenicity Following DTwP-Hepatitis B-Hib-IPV Vaccine (Bio Farma) in Indonesian Infants](https://trialight.com/data/trial/phase-i-ii-open-label-randomized-safety-and-immunogenicity-bfb8e100-95ce-4a58-837c-1b489ed8dce4.md)
- S9427, Suramin in Treating Patients With Stage III or Stage IV Adrenocortical Cancer Incurable by Surgery
- Safety and Immunogenicity of Vi-DT Typhoid Conjugate Vaccine (Bio Farma) in Adults and Children (Phase I)
- Study of Suramin in Subjects With Furosemide-Resistant AKI
- Suramin and Either Docetaxel or Gemcitabine in Treating Patients With Stage IIIB or Stage IV Platinum-Refractory Non-Small Cell Lung Cancer
- Suramin and Paclitaxel in Treating Women With Stage IIIB-IV Breast Cancer
- Suramin in Treating Patients With Recurrent Bladder Cancer
- Suramin in Treating Patients With Recurrent Primary Brain Tumors
- Suramin in Treating Patients With Refractory or Relapsed Multiple Myeloma or Castleman's Disease
- Suramin Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
- Suramin, Paclitaxel, and Carboplatin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer

### In development for (2)

- Human African trypanosomiasis Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2

### Targets (1)

- [FGF1](https://trialight.com/data/target/fgf1-e02303a0-f5a6-577b-97d6-312b9cfdd14d.md) Acidic fibroblast growth factor inhibitor

---

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