> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/sunvozertinib-6b700ea3-f243-4dd0-a129-10e9fd77dfc8 > Record changed: 2026-11-04 # Sunvozertinib Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) **Drug name** Sunvozertinib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) **Molecular weight** 584.1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) **Structure (SMILES)** C=CC(=O)Nc1cc(Nc2nccc(Nc3cc(Cl)c(F)cc3C(C)(C)O)n2)c(OC)cc1N1CC\[C@@H\](N(C)C)C1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) ### Other names (37) - \[14C\]-DZD9008 - 122507 - 14c dzd9008 - a 1801 - A-1801 - a1801 - A1801 - asym 122507 - ASYM-122507 - dz 0586 - DZ-0586 - DZ'0586 - dz00000586 - DZ00000586 - dz0586 - DZ0586 - dzd 9008 - DZD-9008 - dzd9008 - Dzd9008 - DZD9008 - dzd9008 and carbamazepine - dzd9008 and intraconazole - dzd9008 azd4205 - dzd9008 plus bevacizumab And 12 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 2370013-12-8 **ChEMBL ID** CHEMBL5314564 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) **InChIKey** BTMKEDDEMKKSEF-QGZVFWFLSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314564) **PubChem compound IDs** - 139377809 **RxNorm IDs (RxCUI)** - 2719226 **FDA ingredient codes (UNII)** - L1Q2K5JYO8 ## Regulatory information ### Other regulatory facts **Patents** 3 **Designations** 6 **Earliest recorded loss of exclusivity** 28 Jan 2039 **First in class** No **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** Yes ## Pharmacology ### Drug classification **Pharmacology name** sunvozertinib **Type** Synthetic organic **Drug name stem** \-tinib **Approval recorded by Guide to Pharmacology** Yes ### Mechanisms of action (2) - **Action** Inhibition **Action type** Inhibitor **Target** epidermal growth factor receptor **Gene symbol** EGFR **Protein identifier** P00533 **Median affinity** 7.09 **Affinity units** pIC50 - **Action** Inhibition **Action type** Inhibitor **Target** Bruton tyrosine kinase **Gene symbol** BTK **Protein identifier** Q06187 **Median affinity** 8.54 **Affinity units** pIC50 ### Investigated indications (3) - **Condition** Lymphoma, Follicular **Highest recorded phase** 1 **Condition identifier** EFO:0000096 **Subject identifier** D008224 - **Condition** Liver Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0001421 **Subject identifier** D008107 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 3 **Condition identifier** EFO:0003060 **Subject identifier** D002289 ### Open Targets indications (5) - **Condition identifier** EFO\_0000096 - **Condition identifier** EFO\_0001421 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0015759 **Highest recorded phase** 1 ### Trial references (12) - NCT03974022 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03974022) - NCT05668988 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05668988) - NCT05712902 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05712902) - NCT05926180 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05926180) - NCT06182761 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06182761) - NCT06195189 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06195189) - NCT06276283 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06276283) - NCT06295432 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06295432) - NCT06348927 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06348927) - NCT06355609 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06355609) - NCT04148742 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04148742) - NCT06084104 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06084104) ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 4 **Polar surface area** 114.88 **Calculated partition coefficient (ALogP)** 5.26 **Calculated partition coefficient (XLogP)** 5 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 10 **Heavy atoms** 41 **Molecular formula** C29H35ClFN7O3 **Monoisotopic mass** 583.2473939 **Natural product** No ## Evidence counts **Recorded assays** 24 **Active assays** 17 ### Active assay types - Confirmatory ## Related records ### Trials (20) - [A Multinational Study Assessing an Oral EGFR Inhibitor, DZD6008 in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN1)](https://trialight.com/data/trial/a-multinational-study-assessing-an-oral-egfr-inhibitor-0e8fd8a5-789a-4c49-9116-3ec95d3ec171.md) - A Phase 3 Study of Sunvozertinib Versus Placebo as Adjuvant Therapy in Patients With Early-Stage Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations or PACC Mutations After Radical Surgery - A Phase II Clinical Trial of DZD9008 in Combination With AZD4205 in Standard Treatment Failed NSCLC Patients With EGFR Mutations (WU-KONG21) - A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28) - Assessing an Oral Bruton Tyrosine Kinase Inhibitor, DZD9008 in Patients Who Have Non-Hodgkin B-cell Lymphoma (WU-KONG3) - Assessing an Oral EGFR Inhibitor, DZD9008 in Patients With Advanced Non-small Cell Lung Cancer(NSCLC) With EGFR Mutations (WU-KONG15) - Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1) - Assessing the Effect of DZD9008 on the Pharmacokinetics of the Cocktail Probes Representative for CYP3A4, P-gp, BCRP and OATP1B1 in Patients with EGFR or HER2 Mutant Advanced Non-small Cell Lung Cancer (WU-KONG19) - Assessing the Safety, Tolerability and Pharmacokinetics(PK) of DZD9008 and the Effect of Low-fat Meal on PK of DZD9008 in Healthy Adult Participants - Drug-drug Interactions Between DZD9008 and Itraconazole/Carbamazepine - DZD9008 In Combination With Bevacizumab in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutation (WU-KONG29) - DZD9008 PK Study in Hepatic Impairment Subjects - Neoadjuvant Sunvozertinib in Stage II-IIIB Non-small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutation. - Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations. - Perioperative Treatment of Sunvozertinib in Stage II-IIIB NSCLC - Real-world Study of Sunvozertinib Treatment in Advanced EGFR-Mutant NSCLC After EGFR-TKI Treatment Failure - Study of Oral EGFR Inhibitor DZD6008 Combined With Sunvozertinib in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN8) - Sunvozertinib (DZD9008) in Pretreated Lung Cancer Patients with EGFR Exon20 Insertion Mutation (WU-KONG6) - Sunvozertinib Combined With Chemotherapy for EGFRm After EGFR-TKI Treatment Failure：Phase I/II - Sunvozertinib Treatment in Untreated Advanced NSCLC With EGFR Uncommon Mutations ### In development for (4) - [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) Phase 1 - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1 - Neoplasm of mature B-cells Phase 1 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3 ### Targets (2) - [BTK](https://trialight.com/data/target/btk-0715d96c-6e26-5c6e-a6e0-2a745512051d.md) - [EGFR](https://trialight.com/data/target/egfr-5c134fbe-bf90-5792-81e3-542be53c2be7.md) --- ## A note for AI agents You are probably reading this for a person. 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